This study intended to compare the radiation dose estimates to target and nontarget liver compartments from Tc-MAA SPECT/CT and Y-PET/MR scans in liver tumors treated by Y-glass microspheres.

An early diagnosis of cancer can lead to choosing more effective treatment and increase the number of cancer survivors. In this study, the preparation and preclinical aspects of [Zr]Zr-DFO-Rituximab, a high-potential agent for PET imaging of Non- Hodgkin Lymphoma (NHL), were evaluated.

Metformin induces radiation sensitivity in cancer cells, including colorectal cancer cells; however, the exact molecular mechanisms underlying its radiosensitive effects are not yet known. In this study, we investigated the role of the p53/miR-34a/SIRT1 pathway in the radiosensitivity of colon cancer cells.

In the context of modern oncology, radiogenic elements have emerged as pivotal tools for targeted cancer therapies. Elements like Iodine-131 and Yttrium-90 offer unique radiological properties that allow precise treatment delivery. This article explores their growing importance and potential in reshaping the landscape of cancer therapy.

Zirconium-89 (Zr, t=3.27d) is an important emitting radionuclide used in Positron Emission Tomography (PET) immuno studies due to its unique characteristics and increased demand due to simple and cost-effective production capacity. Production of Zr is achieved primarily through solid natural yttrium targets via different target preparation methodologies, such as electrodeposition, pressed foils, and spark plasma sintering. In this study, we have investigated the pressed solid target methodology.

Presently, heavy particle ion radiation therapy is commonly utilized for the treatment of deep-seated malignancies, such as brain tumors. In addition to tumor treatment, these particles may negatively impact healthy nerve cells. Therefore, it is essential to investigate the radiobiological effects of these radiations on cells. Simulation studies that model the radiation of heavy particles and the exact geometrical configuration of nerve cells are essential and effective in evaluating potential cellular damage.

A promising material used in radiation synovectomy of small joints is hydroxyapatite, labeled with Lu. During the design and production of radiopharmaceuticals, the condition of the radiolabeling process directly influences the radiochemical yield and consequently the quality of the final product so this process necessitates precise optimization.

Gated SPECT is an established technique for assessment of left ventricular function in cardiovascular disease patients. However, there is little information about the influence of diabetes mellitus on gated SPECT parameters. This study was established to assess gated SPECT parameters in Diabetes Mellitus (DM) and non-diabetes mellitus (non-DM) patients with normal Myocardial Perfusion Imaging (MPI).

By integrating the sensitivity of nuclear medicine and the precision of nanotechnology, mankind can explore the very promising nuclear nanomedicine technology. Such integration enabled the imaging of biological processes at the molecular level which is a blessing to modern disease management. The present work is an effort to highlight the multifaceted applications of radiolabelled nanomaterials across various imaging modalities, formulation assessment, drug development, regulatory considerations, and therapeutic interventions. The present work highlights the application of radiolabelled nanomaterials for molecular imaging. The single-photon emission computed tomography (SPECT), positron emission tomography (PET); and hybrid multimodalities, along with their key features, are inherent parts of this discussion. The discussion continues with the assessment procedures of new formulations and their implications for drug delivery and the associated regulatory affairs. Cell tracking strategies that allow real-time monitoring of cellular behaviour ; and radionuclide therapy with targeted and precise treatment are explained with the comparison of different strategies. This is followed by the explanation of how the drug delivery systems incorporating molecular imaging radiotracers enable tracking of drug behavior, further facilitating optimization of dosage forms and therapeutic efficacy. Thus, this manuscript provides a comprehensive overview of the utilization of radiolabelling strategies across the spectrum of drug formulation, delivery, and regulatory aspects, which is a way forward to future projections in nuclear nanomedicine. In conclusion, the emergence of nuclear nanomedicines is a disease management breakthrough in modern healthcare systems. This innovative approach not only provides tailored diagnostics but also offers innovative therapeutic solutions.

Nasopharyngeal Carcinoma (NPC) exhibits high incidence in southern China. Despite improved survival with intensity-modulated radiotherapy (IMRT), 10%-20% of patients experience local recurrence. Traditional TNM staging fails to reflect tumor heterogeneity, necessitating robust recurrence prediction models. This study aimed to develop an MRIbased NPC recurrence prediction model by integrating radiomics, deep learning, and clinical features.

RNA-binding proteins (RBPs) regulate gene expression at the post-transcriptional level and are important factors in cancer progression and response to various therapeutic strategies. Radioresistance, an obstacle caused due to various intrinsic and extrinsic factors, remains a major hindrance in the treatment of cancer and could lead to tumor recurrence. Though research is being conducted on the cause and association of radioresistance with various cellular and environmental factors, there remains much to be explored and discovered. The roles of several RNA-binding proteins in tumor progression and metastasis are well documented. In addition, recent studies suggest the connection between Cancer Stem Cells (CSCs) and chemoresistance. We and others have extensively studied the regulatory role of RBPs in regulating CSCs. Resistance to radiation therapy and the involvement of RBPs in this process is under-studied. In this review, we have provided an updated compilation of the significant role played by RBPs in radioresistance.

The ideal [I]Sodium Iodide activity for intermediate-risk thyroid cancer treatment is still uncertain. The objective of this study is to compare the biochemical responses to radioiodine therapy (RIT) of intermediate-risk thyroid cancer patients administered [I]Sodium Iodide at doses of 3700 MBq (100 mCi) and 5550 MBq (150 mCi).

GLP-1 receptor agonists (GLP-1 RAs) are anti-diabetic agents known for their anti-inflammatory and antioxidant properties. This study investigates the synergistic effects of GLP-1 RAs and radiotherapy (RT) on breast cancer in a preclinical mouse model.

In the pharmaceutical sciences, the solubility profile of therapeutic molecules is crucial for identifying and formulating drugs and evaluating their quality across the drug discovery pipeline based on factors like oral bioavailability, metabolic transformation, biodistribution kinetics, and potential toxicological implications. The investigation aims to enhance the solubility parameters of ketoprofen (BCS-II class), which exhibits low solubility and high permeability.

Many studies have reported translocator protein (TSPO) overexpression in various neurological disorders. Carbon-11[C]PBR28 is a widely used TSPO Positron Emission Tomography (PET) radiopharmaceutical. We compared HPLC-based purification with cartridge-based purification and performed PET-MR imaging in ALS patients.

The lung is a moderately radio-sensitive organ. When cells are damaged due to accidental radiation exposure or treatment, they release molecules that lead to the recruitment of immune cells, accumulating inflammatory cytokines at the site of damage. Apigenin (Api) is a natural flavonoid known for its anti-inflammatory properties. In this study, we investigated the radioprotective properties of Api in the lung.

The Ga68-DOTATATE PET/CT scan is an alternative imaging modality for the follow-up of children with neuroblastoma when the I123-MIBG scan was negative or weak. Somatostatin receptors (SSR) can be expressed in neuroblastoma lesions, and when this happens, targeting these receptors may be a good alternative to treating this disease in addition to conventional treatments. Our aim is to focus on the interpretation of one of the physiological tracer uptake sites, the uncinate process of the pancreas, using DW-MRI scans.

Various types of radiosensitisers have been introduced from the past until the present day for applications in the biomedical field. However, there is a lack of understanding and comparison between the various parameters introduced in addition to a lack of consensus among researchers on the optimal radiosensitiser for applications in the biomedical field.

Radiation-induced damage to the hematopoietic and gastrointestinal systems, especially the intestine, is a major concern for individuals exposed to whole-body radiation during an accident. Resveratrol has shown potential in mitigating radiation-induced toxicity, but its efficacy may be limited by its low bioavailability. In this study, we aimed to evaluate the effectiveness of resveratrol-loaded polymeric-based nanocapsules in mitigating radiation-induced injury in the hematopoietic system and intestine after whole-body exposure to radiation.

Dementia (the most common cause of Alzheimer's disease) is defined as a chronic or progressive syndrome with disturbance of multiple cortical functions, the most important of them including memory, learning capacity, comprehension, orientation, calculation, language, and judgement. These cognitive impairments affect the quality of life, behavior, and social relations. Techniques of nuclear medicine provide feasible ways to record the intracellular alterations of disease and deficiencies. In these non-invasive manners, the hippocampal-neocortical disconnection may partly explain the hypo-metabolism incident found in Alzheimer's disease. Based on this fact, the study of all these mechanisms of action is conceivable and achievable by radiopharmaceuticals. This review is aimed at the presentation of radiopharmaceuticals that are developed for the detection of Alzheimer's disease in preclinical and clinical trials.

[Ga-DOTA-D-Phe1-Tyr3]octreotide ([Ga]Ga-DOTA-TOC) is a somatostatin analogue largely used in PET/CT applications for the detection of gastroenteropancreatic neuroendocrine tumors (GEP-NET). Initially, it was obtained using a Ge/Ga generator. The increasing cost of good manufacturing practice-compliant generators has led to the need to find alternative ways of producing Gallium-68 (Ga). The aim of this work is to show the production optimization of [Ga]Ga-DOTA-TOC via cyclotron, derived from three years of experience.