Vitamin D receptor (VDR) variations have attracted attention because of their potential impact on metabolic regulation and liver health. This study aimed to investigate the association between VDR polymorphisms and clinical parameters as well as the risk of metabolic dysfunction-associated steatotic liver disease (MASLD; formerly nonalcoholic fatty liver disease) in a Turkish population.

Patients with rheumatoid arthritis (RA) can develop interstitial lung disease (ILD) with increased morbidity and mortality. The diagnostic values of serum carcinoembryonic antigen (CEA), cancer antigen (CA) 125, and human epididymis protein 4 (HE4) in these patients was unclear.

Congenital hypofibrinogenemia is a genetic disorder caused by defects in the fibrinogen gene. We identified a case of congenital hypofibrinogenemia with mutations in the FGA, FGB, and FGG genes associated with bleeding risk and conducted experimental studies to explore the condition's pathogenesis.

This study aimed to investigate the utility of vascular endothelial growth factor (VEGF) and osteopontin (OPN) as predictive biomarkers in hepatocellular carcinoma patients (HCC) and cirrhosis and identifying its potential diagnosis of HCC.

In this study, we aimed to evaluate serum creatinine levels with reference change value in patients receiving treatment with gentamicin.

Sepsis represents a critical response to infection; it is characterized by systemic inflammation, shock, and potential organ failure. Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) has been identified as a crucial marker in sepsis, connecting the activation of innate immunity to systemic inflammation.

Hepatocellular carcinoma (HCC) diagnosis requires a combination of elevated ɑ-fetoprotein (AFP) levels and liver imaging. We evaluated the role of prothrombin induced by vitamin K antagonist-II (PIVKA-II) in patients with suspected HCC.

We sought to identify independent risk factors for stroke in patients with hypercholesterolemia and develop a clinically applicable risk prediction nomogram using a nationally representative dataset.

The American Society for Clinical Pathology Board of Certification Research and Development Committee has undertaken regular surveys of Medical Laboratory Science (MLS) education programs. Results of previous surveys were reported in 2019 and 2022. The purpose of these recurring surveys is to support MLS programs in their educational mission by providing information about current issues and trends that may affect program resources and MLS education, including data for grant applications, funding requests, and strategic planning. Program-related topics covered in the surveys included program director and faculty education and certification requirements, program structure and duration, student grade point averages and acceptance data, clinical site numbers and status, and faculty numbers and vacancies.

Cell-derived microparticles that promote coagulation can lead to transfusion-related complications. Although age-dependent changes in hemostasis are known, the impact of donor age on microparticle concentration variability remains largely unexplored. We sought to determine microparticle concentrations and investigate their relationship with donor age.

We sought to identify a diagnostic panel based on routine clinical biomarkers that can distinguish chronic kidney disease (CKD) from non-CKD among patients who have chronic heart failure (HF) and predict changes in kidney function in this patient population.

Fentanyl, a highly potent synthetic opioid, has contributed to a rapid rise in opioid-related overdoses and fatalities nationwide. Consequently, the need for accurate and timely testing for fentanyl has become critical. Immunoassay screens, reported as presumptive positive or negative, help address this need. We sought to compare the clinical performance of 2 US Food and Drug Administration (FDA)-approved fentanyl immunoassays-the Thermo Scientific DRI Fentanyl II Drugs of Abuse Assay and the Lin-Zhi International LZI Fentanyl (Q) Enzyme Immunoassay-for detection of fentanyl and its metabolites in urine, using liquid chromatography-tandem mass spectrometry (LC-MS/MS) as the reference method.

Laboratory reference ranges and phlebotomy guidelines are derived from ambulatory individuals, whose values reflect reduced plasma volume from hydrostatic pressure shifts. These conditions may not represent intensive care unit (ICU) patients, who remain supine for extended periods. This study evaluated the impact of posture on routine hematologic and biochemical laboratory tests in ICU patients.

We sought to establish trimester-specific reference intervals of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) using real-world data.

The American Society for Clinical Pathology Board of Certification's Research and Development Committee launched a survey to collect data on the Medical Laboratory Technician (MLT) education programs. The survey included MLT program directors, educators, administrators, faculty, and other program-related individuals in university and college programs. The survey gathered information to support MLT program directors and faculty in educating students, especially to clarify current issues and reveal trends that may affect future program resources and the quality of MLT education. Topics in the surveys included demographics; educational level and rank; certification patterns; experience; responsibilities; salaries; retirement; and program-specific areas such as minimum grade point averages (overall and in science) for admission, vacancies, capacity, and clinical sites.

The early diagnosis of acute coronary syndrome remains challenging, with high-sensitivity cardiac troponin (hs-cTn) exhibiting limitations in the first 3 hours after symptom onset. Cardiac myosin-binding protein C (cMyc) shows promise as an earlier, more specific biomarker.

Multiple myeloma (MM) is characterized by the abnormal proliferation of plasma cells, resulting in the overproduction of distinctive monoclonal proteins (M-protein). Suspected MM necessitates screening for M-protein through a combination of serum protein electrophoresis, serum immunofixation (SIFE), and serum free light chain (SFLC) determination. An M-protein appears as a relatively restricted band on agarose gel, where migration in ɑ-2 is rare.

To ensure adequate quality of clinical samples, laboratories must control samples' postanalytical preservation. We checked the stability limit of lactate dehydrogenase (LDH) and confirmed the 72-hour limit the manufacturer proposes, then evaluated sample stability under our working conditions using new recommendations for stability studies.

Autoimmune encephalitis can occur in isolation or as a postinfectious complication, such as following infection with SARS-CoV-2.

This prospective study assessed relationships between COVID-19, humoral immunity, and common laboratory test results.

Rapid and accurate identification of pathogens is essential for managing lung infections in patients following kidney transplantation. This study aimed to compare the diagnostic performance and clinical utility of conventional detection methods and metagenomic next-generation sequencing (NGS) in kidney transplant recipients with respiratory infections.