Ovarian cancers have been the most lethal gynecologic malignancies worldwide, with survival outcomes remaining poor despite therapeutic advances. Since TP53 is the most frequently mutated gene in ovarian cancers, it highlights the central role of p53 dysfunction in promoting tumor initiation, genomic instability, and progression. Beyond classical loss of transcriptional activity, mutant p53 may exert dominant-negative effects on residual wild-type protein and acquire oncogenic gain-of-function properties that promote invasion, metastasis, and resistance to chemotherapy. Nevertheless, despite extensive efforts, effective therapeutic agents targeting TP53-mutant tumors remain elusive, representing a major unmet medical need.

This study aimed to evaluate the relationship between hyperemesis gravidarum (HG) severity and liver-related indices-Albumin-Bilirubin (ALBI) and Aspartate Aminotransferase to Platelet Ratio Index (APRI)-to explore their potential as non-invasive biomarkers in HG.

To evaluate pregnancy outcomes by treatment approach and assess the appropriateness and safety of surgical intervention in patients with infertility and uterine adenomyosis.

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE) carries high risk of adverse maternal and fetal outcomes. This Study aimed to evaluate the effectiveness of low-dose low-molecular-weight heparin (LMWH) combined with low-dose acetylsalicylic acid (ASA) prophylaxis in women with a history of VTE.

With the widespread use of assisted reproductive technology (ART), the incidence of subchorionic hematoma (SCH), a pregnancy-related complication that poses a serious threat to the health of both mother and child, has increased significantly. This review systematically investigates the pathogenesis and risk factors of SCH in the context of ART, focusing on the relationship between the occurrence of ART and SCH.

Preeclampsia is an obstetric complication with morbidity and mortality that occurs after the 20th week of pregnancy. Cadherins, which play a role in trophoblast development and placentation, are blamed for the pathogenesis of this disease and our aim was to investigate the potential of cadherin-18 level to predict pre-eclampsia.

Gender perception and misogyny are important factors affecting women's health. The study aims to determine individuals' attitudes, knowledge, and awareness regarding the concept of metaverse and examine their relationship with gender perception and misogyny.

This study aimed to evaluate the correlations between programmed death-ligand 1 (PD-L1) expression, the mismatch repair system, and p53 status in endometrial cancer, considering tumor stage.

Diffuse uterine leiomyomatosis (DUL) is characterized by numerous uterine leiomyomas within and diffusely replacing the myometrium. However, because of its rarity, the prevalence, diagnostic criteria, and standard treatment for patients with DUL who wish to preserve their fertility remain unknown. This study aimed to clarify the current status of the diagnosis of DUL in Japan.

Previous studies reported inconsistent results on the effects of maternal smoking and drinking on pre-eclampsia (PE). Furthermore, some studies indicated that the development of PE may also be attributable to unhealthy behaviors from men. Hence, this study aimed to evaluate the association between smoking and drinking by couples and PE in the Asian population.

To investigate recent trends in laparoscopic and robot-assisted surgery in gynecology in Japan.

To identify the predictors for periureteral adhesions preoperatively.

This study investigated the reasons behind the decreasing trend of lymph node dissection for endometrial cancer (EC) in Japan, focusing on the impact of minimally invasive surgery (MIS) adoption, evolving clinical guidelines, and physician work-style reform.

This review aims to explore Female Genital Tuberculosis (FGTB) as a significant, yet underdiagnosed cause of subfertility, with a focus on its clinical presentation, diagnostic complexities, and implications for reproductive outcomes. It highlights the importance of early recognition and the role of endoscopic findings in guiding timely treatment.

Patients with endometriosis are at a high risk of developing pelvic inflammatory disease. This case series presents three cases of colo-ovarian fistulas associated with endometriosis, highlighting the potential for conservative management in selected cases. Case 1 involved a 36-year-old woman in whom suspected communication between the colon and an endometriotic cyst was noted on computed tomography and magnetic resonance imaging (MRI). Case 2 involved a 42-year-old woman who presented with a colo-ovarian fistula on MRI. Case 3 involved another 42-year-old woman with a sigmoid colon perforation who was retrospectively diagnosed with a colo-ovarian fistula. All cases were associated with endometriosis. In Cases 1 and 2, symptoms were successfully managed conservatively. In Case 3, the colo-ovarian fistula only became apparent following hysterectomy and was treated by surgery. Although surgical intervention is commonly performed for colo-ovarian fistulas, our findings suggest that conservative treatment may be an option in select cases with endometriosis-associated fistulas.

Nausea and vomiting of pregnancy (NVP) has been suggested as a potential risk factor for postpartum depression. However, existing evidence remains inconclusive because of variations in NVP definitions, limited sample sizes, and limited consideration of parity, despite potential differences in the caregiving burden between these two groups. We examined the association between postpartum depressive symptoms and the severity of NVP, assessed using multiple clinical criteria, stratified by parity.

To clarify the current status of human T-cell leukemia virus type 1 (HTLV-1) among pregnant women in Japan, with a focus on its prevalence by age and region and the contribution of horizontal transmission.

The aim of this study was to evaluate the effect of visceral, subcutaneous and intermuscular adipose tissue areas measured by computed tomography at diagnosis on survival in ovarian cancer patients receiving second-line bevacizumab treatment.

To examine the short-term impacts of Japan's newly implemented physician working-hour limits (April 2024) on working conditions, self-directed professional development (SDPD), defined as activities undertaken outside working hours to enhance one's professional skills, and work-related happiness among obstetrician-gynecologists (OB-GYNs).