Managing comorbidities alongside guideline-directed medical therapy is essential in heart failure (HF) treatment. Intravenous (IV) iron therapy is recommended for HF patients with left ventricular ejection fraction (LVEF) <50% to correct iron deficiency. Traditional markers such as ferritin and transferrin saturation (TSAT) are affected by inflammation and have delayed responses, limiting their clinical utility. This study aimed to evaluate early response to IV iron therapy by monitoring reticulocyte counts, a parameter unaffected by inflammation.

The hemoglobin-to-red blood cell distribution width ratio (HRR) is a new inflammatory marker in evaluating tumor prognosis. However, its application in cardiovascular diseases (CVDs) is relatively limited. This research was designed to illuminate the relationship between HRR and mortality in patients with aortic dissection (AD).

Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy and myocardial fibrosis, which significantly increases the risk of sudden cardiac death (SCD). Existing risk stratification models are limited in predicting SCD risk in patients within the "gray zone"-those with intermediate risk. This study investigates the prognostic utility of the Index of Cardiac Electrophysiological Balance (ICEB) and its corrected variant (ICEBc) in predicting ventricular arrhythmias (VAs) in HCM. To evaluate the predictive value of ICEB and ICEBc for Life-Threatening Arrhythmias (LTA) and non-sustained ventricular tachycardia (NSVT) in HCM and compare their performance with traditional repolarization parameters and the European Society of Cardiology (ESC) SCD Risk Score.

Myocardial ischemia-reperfusion (I/R) injury is aggravated in type 2 diabetes mellitus (T2DM) due to metabolic dysfunction, inflammation, and apoptosis. This study investigated the cardioprotective role of alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, compared with atorvastatin.

Erectile dysfunction (ED) and coronary artery disease (CAD) frequently coexist, sharing common risk factors and pathophysiological mechanisms. The frontal QRS-T angle (fQRSTa), a novel electrocardiographic marker reflecting ventricular depolarization-repolarization heterogeneity, has been linked to adverse cardiac outcomes. However, the combined prognostic value of ED and fQRSTa in predicting CAD severity remains unexplored. The aim was to investigate whether the coexistence of ED and widened fQRSTa is associated with increased CAD severity, and to evaluate their individual and combined utility in identifying patients with advanced CAD.

Atrial tachycardia (AT) is a commonly encountered rhythm disorder and most patients require catheter ablation. In this study, the aim was to evaluate the outcomes of catheter ablation in patients with symptomatic AT, define acute and long-term outcomes, and determine the clinical and electrophysiological features that affect these outcomes.

Calcific aortic valve stenosis (CAVS), the predominant valvular heart disease in developed countries, arises primarily from metabolic and inflammatory dysregulation. The triglyceride-glucose (TyG) index, a composite biomarker of insulin resistance and systemic inflammation, has been associated with cardiovascular diseases. However, its causal association with CAVS remains unclear. This study employs bidirectional Mendelian randomization (MR) to elucidate the potential causal relationship between the TyG index and CAVS.

While both sarcopenia and obesity independently elevate cardiovascular disease (CVD) risk, their combined effects, known as sarcopenic obesity (SO), remain incompletely understood. This systematic review and meta-analysis aimed to evaluate the association between SO and the risk of CVD and CVD-related mortality.