Anxiety disorders are psychiatric ailments that affect people throughout the world. Several studies have revealed that the development of anxiety is affected by changes in glutamatergic neurotransmission. Metabotropic glutamate receptors (mGluRs) can be allosterically modified, offering a new strategy for developing specific therapeutic agents that affect the cell membrane. Allosteric modulators have many advantages over other therapeutic options. In the field of stress treatment modulation, they can maintain the properties of natural glutamatergic neurotransmission. This review describes the design of allosteric modulators and the advantages of this class of compounds over current stress drugs.

Status epilepticus (SE) is a serious neurological condition with a high risk of complications and mortality. We described adult patients who required admission to the intensive care unit (ICU) for SE and assessed their prognosis.

To evaluate the impact of QHN combined with FH versus FH monotherapy on vestibular migraine (VM) METHODS: The study included patients treated for VM with either QHN+FH or FH alone between September 2022 and September 2023 at The First Affiliated Hospital of Guangdong Pharmaceutical University in Guangzhou, Guangdong Province, China. The primary outcome was the change of Dizziness Handicap Inventory (DHI) before and after 8 weeks of treatment. Secondary outcomes included changes in the Video Head Impulse Test (v-HIT) results before and after 8 weeks of treatment, and the recurrence of vertigo attacks at 4 and 8 weeks post-treatment.

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by neuroinflammation and progressive neurodegeneration, leading to significant physical and cognitive impairments. Rehabilitation, particularly physical therapy, has emerged as a crucial component in managing MS-related disability by improving mobility, reducing fatigue, and enhancing overall quality of life. This narrative review investigates current international guidelines on physical therapy and rehabilitation for MS. Literature search in databases (January 2010 until August 2025) resulted in three guidelines that met the inclusion criteria. Evidence suggests that structured aerobic and resistance training programmes, combined with balance and flexibility exercises, contribute significantly to maintaining functional independence. Additionally, assistive technologies offer promising advances in patient-centred care. However, challenges such as limited accessibility, variability in disease presentation, and adherence to rehabilitation programmes pose significant barriers. This narrative review highlights the need for comprehensive and multidisciplinary clinical guidelines to optimize physical therapy interventions and improve the long-term well-being of MS patients.

To address the gap in understanding post-surgical quality of life, depression, and anxiety among brain tumor patients in Saudi Arabia.

To determine the prevalence of fatigue and depression in patients with epilepsy (PWE), explore their relationship, and identify the factors associated with fatigue in this population.

To identify the genetic landscape of CMT in Saudi Arabia.

To evaluate the effectiveness and safety of Stiripentol (STP) in individuals with Dravet syndrome resulting from SCN1A gene mutation METHODS: A retrospective study with a descriptive focus was carried out in 2023, involving 44 patients diagnosed with Dravet Syndrome, with data collected by chart review and interviews of caregivers based on a pre-structured data extraction sheet. Data included age of seizure onset, SCN1A gene variant, duration of seizures before STP initiation, age at the time of starting STP administration, change in seizure frequency or duration after STP initiation, and at 6 months following initiation, and concomitant anti-seizure medication.

To investigate the factors affecting participation in rehabilitation in patients with spinal cord injury.

A 67-year-old male presented with sudden headache and decreased consciousness, diagnosed as spontaneous subarachnoid hemorrhage (SAH). Imaging revealed an anterior communicating artery (ACoA) aneurysm and congenital absence of the left internal carotid artery (ICA), confirmed by the absence of the carotid canal. The aneurysm was surgically clipped. Postoperative angiography demonstrated that the left anterior and middle cerebral arteries were perfused via collateral flow from the posterior circulation. The patient made a full recovery. Congenital ICA absence is rare but significantly alters cerebral hemodynamics, especially within the circle of Willis, predisposing patients to aneurysm formation. This case underlines the importance of vascular imaging in patients with SAH and highlights the need for urgent diagnosis and intervention in the presence of congenital vascular anomalies.

To evaluate the use of susceptibility-enhanced sequence with conventional magnetic resonance imaging (MRI) of the brain for identification of venous angiomas in epilepsy work up.

To explore the beneficial effects and mechanisms of Poloxamer 188 (P188) in mitigating cerebral ischemia-reperfusion (I/R) injury in mice.

Brucellosis is a zoonotic infection that affects 500,000 individuals each year worldwide. Neurological complications occur in up to 5% of cases, and ocular involvement is rare. This report describes the case of a 26-year-old woman with progressive lower limb weakness and significant ambulatory impairment following two months of headache, nausea, vomiting, and visual disturbances. The patient had a history of urinary incontinence, lower back pain, and raw goat milk consumption. Clinical examination revealed bilateral papilledema and muscle weakness. Positive Brucella culture, abnormalities in the cerebrospinal fluid, and magnetic resonance imaging findings confirmed the presence of neurobrucellosis. Treatment with antibiotics led to minimal initial improvement. However, significant recovery was observed five months post treatment initiation. This case highlights the importance of considering neurobrucellosis in endemic regions and underscores its distinct clinical and radiological features. Early recognition and treatment are crucial for reducing morbidity.