Cervical cancer (CC) is a widely recognized malignant tumor that imposes a substantial economic burden on the global healthcare system. Currently, treatment options for patients with advanced metastatic and recurrent CC are suboptimal. Therefore, further in-depth research into the characteristics of CC occurrence and metastasis may provide additional reference indicators for patient diagnosis, treatment, and prognosis. This study aims to screen differential genes in CC via transcriptome sequencing and bioinformatics analysis, verify the role of microtubule-associated serine/threonine kinase 1 () in CC, and explore its underlying molecular mechanisms, providing a basis for CC diagnosis and treatment.

Polyamine metabolism supports the growth of myeloid-derived suppressor cells (MDSCs) in gliomas and is involved in developing an immunosuppressive state. However, the molecular patterns and prognostic features in low-grade gliomas (LGG) have not been adequately studied. This study was dedicated to exploring core targets of polyamine metabolism in LGG.

While surgery remains the standard of care for stage II non-small-cell lung cancer (NSCLC) for most patients, numerous older patients are non-surgical candidates because of either frailty or comorbidities. We aim to assess the comparative effectiveness of chemoradiotherapy (CRT) compared to radiotherapy (RT) for older patients with stage II NSCLC using data from the Surveillance, Epidemiology, and End Results (SEER) database and propensity score matching (PSM) methods. Surgery remains the approved standard of care for stage II NSCLC. But for older populations, those aged 65 years or older, they often may not undergo surgery for a variety of reasons.

Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, and lipid metabolism reprogramming plays a crucial role in tumor progression. ATP citrate lyase (ACLY), a key enzyme in lipid synthesis, has been implicated in multiple cancers, but its role in GC remains incompletely understood. This study aimed to investigate the expression, prognostic significance, and potential molecular mechanisms of ACLY in GC, with a particular focus on its relationship with lipid metabolism and ubiquitination.

Thyroid cancer (THCA) is a common endocrine malignancy with diverse prognostic outcomes. The role of dispatched RND transporter family member 3 (DISP3) in tumorigenesis remains unclear. This study aimed to investigate DISP3's biomarker potential in THCA.

Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with limited improvements in survival outcomes. Increasing evidence highlights the role of ferroptosis, an iron-dependent form of regulated cell death, and RNA-binding proteins (RBPs) in tumor progression. However, the prognostic significance of ferroptosis-associated RBPs in HNSCC remains unclear. This study aimed to develop and validate a ferroptosis-associated RBP signature to improve survival prediction and explore its relationship with the immune microenvironment in HNSCC.

Characterized by its significant occurrence and high fatality, hepatocellular carcinoma (HCC) presents a challenge with treatments frequently leading to less than ideal results. The mechanism of action behind disulfidptosis, a newly identified pathway of cell death, is not well comprehended when related to HCC. This research aims to investigate a model that employs long non-coding RNA (lncRNA) associated with disulfidptosis for predicting the prognosis of liver cancer and identifying potential therapeutic measures.

Ovarian cancer (OC) has the highest mortality rate among all gynecological cancers, yet its pathogenesis remains unclear. This study aims to use integrated bioinformatics methods to identify important biomarkers and subtypes closely related to tumor immunity and fatty acid synthesis in OC.

Current prognostic models for metastatic nasopharyngeal carcinoma (M1-NPC) often employ oversimplified "catch-all" classifications that fail to account for the substantial heterogeneity in metastatic patterns and treatment responses. Furthermore, existing tools lack interactive visualization capabilities to support clinical decision-making. In this study, we aim to develop and validate a visual prognostic model for 3-year overall survival (OS) in M1-NPC patients.

Colorectal cancer (CRC) is among the most common and lethal cancers worldwide. Recent advances in tumor immunotherapy have highlighted the importance of T-cell subsets and the tumor microenvironment (TME) in CRC, both critical for mounting a successful anti-tumor immune response. Thus, there is an urgent need for comprehensive research in these areas to accelerate the development of personalized immunotherapeutic strategies for CRC patients. Therefore, this study aims to explore T-cell heterogeneity, identify characteristic genes, and develop a reliable prognostic model to predict patient outcomes and immunotherapy responses.

[This corrects the article DOI: 10.21037/tcr-2024-2482.].

Cervical cancer is a common female malignant tumor which lacks of effective immunotherapy drugs. There are a large number of studies about immune regulation of cervical cancer, but the involvement of innate immunity is rarely reported. As a ligand of NKp30, B7 homolog 6 (B7-H6) is involved in the immune regulation of various tumors. The aim of the present study was to clarify the effect of B7-H6 expression in HeLa cells on the killing function of natural killer (NK) cells.

Gastric cancer (GC), as a heterogeneous disease, lacks clear clinical indications, and existing methods based on histological classification are insufficient for individualized stratified treatment of GC patients. Lipophagy-related genes (LRGs) are involved in the progression of GC, but their role in GC remains unclear. This study aims to develop and validate a lipophagy-related prognostic model to improve the predictive ability for GC prognosis.

Leptomeningeal metastasis (LM) is associated with poor prognosis and affects the quality of life (QOL) of end-stage cancer patients, particularly when accompanied by hydrocephalus. Ventriculoperitoneal shunt (VPS) is recognized as an effective therapy for patients with this condition, but previous studies have focused on clinical effects. This study aimed to explore the predictors of clinical outcome in patients with LM who underwent VPS.

Melanoma is an aggressive malignant tumor, characterized by high mortality. A growing amount of research indicates that the tumor immune microenvironment is closely associated with the survival outcomes and immunotherapy benefit for patients with advanced tumors. However, the molecular mechanisms underlying the effect of the tumor immune microenvironment on metastatic melanoma have not been clarified in detail. Therefore, this study aimed to identify potential effective immune-related tumor biomarkers for the prognosis and treatment of metastatic melanoma.

Breast cancer (BRCA) ranks among the highest commonly occurring malignant tumors globally, posing a significant risk to women's health. Numerous studies suggest that butyrate holds potential as an anti-cancer compound across various human cancers. However, the impact on the initiation and progression of BRCA remains insufficiently explored. Therefore, this study aimed to identify molecular subtypes of BRCA based on butyrate metabolism-related genes, construct a prognostic model, and explore the associated immune landscape to provide insights for prognosis assessment and therapeutic strategies.

The Dynamic Optical Breast Imaging (DOBI) ComfortScan system is a dynamic optical breast functional imaging system that analyses diffused light propagation through breast tissue. It continuously records the physiological properties of the tissue by applying a certain amount of pressure to the breasts that induces changes in blood hemoglobin concentration and the metabolic rates associated with the tumor angiogenesis of breast cancer. This study examined the clinical performance of dynamic optical functional imaging in the detection of malignant lesions, and compared the DOBI system with conventional imaging modalities. This novel diagnostic test addresses critical limitations of conventional imaging by providing functional assessment of tumor angiogenesis through hemoglobin dynamics, particularly valuable for dense-breast patients where mammography (MG) sensitivity declines.

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy arising from the intrahepatic bile duct epithelium, with increasing global incidence and poor prognosis due to late diagnosis and limited therapeutic options. Current prognostic models such as tumor-node-metastasis (TNM) staging exhibit suboptimal accuracy and lack integration of molecular biomarkers. Our study aims to explore the prognostic significance of (encoding GLUT1) in iCCA and develop a predictive nomogram integrating clinical features.

Colorectal cancer (CRC) progression and treatment resistance are closely linked to cancer stem cells (CSCs), yet their spatial dynamics and regulatory mechanisms remain poorly characterized. This study integrates single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to define CRC stem cell subtypes (Co-CSS), map their interactions within the tumor microenvironment, and identify novel prognostic markers driving clinical outcomes.

Patients with advanced endometrial cancer (EC) who undergo surgery after neoadjuvant chemotherapy have improved progression-free survival and overall survival rates. The systemic immune-inflammation index (SII), a novel comprehensive inflammatory biomarker, is associated with the development of various non-oncologic diseases and can predict the treatment efficacy and prognosis of cancer. The aim of this study was to determine the predictive value of SII for the efficacy of neoadjuvant chemotherapy in patients with inoperable EC or with surgical contraindications.

Gastric cancer (GC) is a highly prevalent and lethal malignancy worldwide. Notwithstanding advances in treatment, suboptimal patient outcomes highlight the urgent need for novel therapeutic targets to improve survival. This study aimed to explore the influence of keratin 23 (KRT23) on the proliferation, migration, and invasion of GC cells, as well as its underlying molecular mechanism.