Renin suppression persists in many patients with primary aldosteronism despite targeted medical treatment, which might indicate suboptimal mineralocorticoid receptor blockade. This study systematically reviewed the evidence for an association between post-treatment renin status and cardiovascular, renal, and mortality outcomes in medically treated primary aldosteronism.

Cyclic Cushing's syndrome (cCS) features fluctuating cortisol secretion, often causing diagnostic errors or delays, and possibly poorer outcomes. We aimed to identify unpublished cCS cases to characterise clinical challenges and guide strategies for improving outcomes by characterising cycle patterns, peak frequency, and evaluating complications.

Cancer burden among adolescents and young adults (AYAs) aged 15-39 years has increased during the past two decades, with thyroid cancer being a major contributor. We aimed to comprehensively evaluate trends and the current burden of thyroid cancer among AYAs globally.

Higher than normal glucose concentrations have been linked to an increased risk of cancer. We aimed to describe the disease trajectories from prediabetes to cancer, accounting for the possible conversion to type 2 diabetes and risk of death.

Subgroups of adult-onset diabetes, namely severe autoimmune diabetes (SAID), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), and mild obesity-related diabetes (MOD) or mild age-related (MARD) diabetes, have been defined with clinical variables and a machine-learning approach. Our aim was to describe their long-term outcomes and mortality.

Adrenal tumours have become a common incidental finding in the radiological evaluation of patients. Estimates suggest that 1-10% of the general population currently harbours an adrenal tumour, peaking in prevalence in the seventh and eighth decades of life. Advances in CT and MR have contributed to improved characterisation of adrenal masses, and novel radiopharmaceuticals are being developed for molecular characterisation and disease subtyping. As a result, the imaging and management of adrenal tumours have been important subjects of many guidelines and consensus statements. New radiomics approaches, together with machine learning, are now being introduced and are quickly shaping the way that imaging data are analysed and interpreted. Furthermore, the development of theranostics links the molecular biology of functioning tumours to targeted treatment options. In this Review, we summarise up-to-date imaging and follow-up approaches for adrenal tumours to provide patients with the most accurate diagnosis, thereby avoiding unnecessary additional tests or surgery.

Data regarding the impact of real-time continuous glucose monitoring (rt-CGM) on reducing adverse pregnancy outcomes in women with gestational diabetes are contradictory. We aimed to assess differences in the proportion of large-for-gestational-age (LGA) newborns between women using rt-CGM versus self-monitoring of blood glucose (SMBG).