Update on acute kidney injury: some progresses and a long way to go
Temporal robustness of biomarker-based classification algorithms for sepsis
Heterogeneity of the host response in sepsis hampers development of effective treatments. Several immunobiologically distinct subphenotypes (or endotypes) have been identified using data-driven analyses of single-timepoint biomarker data, but their temporal stability remains uncertain due to dynamic biology and statistical limitations.
No benefit, or no power? The TIMING trial between Atlanta classification and SOFA score for severe acute pancreatitis: author's reply
Thirty years of mHLA-DR research in septic shock: lessons and caveats for clinical translation
Central venous-minus-arterial PCO to arterial-minus-central venous O content ratio is tricky tool to solve the puzzle of lactate sources. Author's reply
Challenging dogma: low-dose norepinephrine and extubation in obese ICU patients
Reassessing open lung ventilation in ARDS: an updated meta-analysis of the 2023 ESICM guidelines highlights risks of routine use and supports individualized strategies
Individualised treatment effects of enhanced early mobilisation in mechanically ventilated patients: a secondary analysis of the TEAM trial
Benefit or harm from early mobilisation (EM) in mechanically ventilated patients may vary by individual patient characteristics. We used machine learning to predict individualised treatment effects (ITEs) in the "Early Active Mobilization during Mechanical Ventilation in the ICU" (TEAM) trial.
Intracranial pressure toxicity: a matter of dose, not thresholds
Cardiogenic shock: from standardization to precision-a new era in critical care cardiology?
Weaning of neuromuscular patients: the reality is probably somewhere in between
Trends in renal replacement therapy use in intensive care unit: insights from a French multicenter cohort
Renal replacement therapy (RRT) during acute kidney injury (AKI) in critically ill patients used to be started early for long. Recent trials supporting a conservative approach with delayed RRT initiation may have influenced clinical practice. We aim to assess temporal trends in the use of RRT among intensive care unit (ICU) patients with AKI over a 12-year period.
Ten ethical challenges in donation after circulatory death (DCD): a practical guide for intensivists
Dexmedetomidine for hyperactive delirium: promising signal or premature conclusion?
Haemoglobin buffering capacity: the missing variable in transfusion physiology after acute brain injury
How large language models can help us write a systematic review
MAKE no mistake: mortality can drown the CKD signal after AKI. Authors' reply
