As mental health challenges continue to increase globally, using rigorous surveillance frameworks is essential for delivering nuanced population-level insights and informing evidence-based policy decisions.

Individuals with schizophrenia spectrum disorders treated with second-generation antipsychotics (SGAs) are at heightened risk for obesity, prediabetes, and type 2 diabetes, contributing to increased cardiovascular morbidity and premature mortality. Early intervention with glucagon-like peptide-1 receptor agonists (GLP-1RAs) may help mitigate long-term cardiometabolic risk.

Randomized clinical trials (RCTs) support apps as scalable, cost-efficient tools for managing depression and anxiety, but concerns about engagement and attrition remain. With the field's rapid growth, there is now an opportunity to generate more precise insights on uptake, attrition, and adherence.

Ketogenic diets (KDs) have been hypothesized to influence mental health through pathways involving mitochondrial function, inflammation, and neurotransmitters, but their therapeutic value in psychiatric populations remains uncertain.

Close social relationships are linked to improved individual health and even longevity. These effects are hypothesized to be mediated through improved neuroendocrine and immune functioning, particularly in individuals who engage in positive and affectionate interactions. However, systematic data examining these factors in humans are currently lacking.

Although the recent proliferation of telemental health care has transformed the delivery of outpatient mental health care for many individuals in the US, little is known about how outpatients are distributed across telehealth, hybrid, and in-person care.

An increasing number of sexual assaults (SAs) are reported. Prior studies show that SA is associated with functional somatic disorder (FSD).

The opioid crisis remains a global public health issue, with poor clinical outcomes, low treatment adherence, and early dropouts being major challenges. These may be driven by a pathological increase in avoidance tendencies in opioid addiction, although this has not yet been demonstrated in humans.

Traditional adoption studies examine disorder-to-disorder parent-offspring transmission. The role of parental genetic risk in offspring disorder transmission can capture indirect genetic effects from parental genotype to parental phenotype to offspring risk.