Critically ill patients in the intensive care unit (ICU) represent a highly heterogeneous population with large variations in the pharmacokinetics (PK) of antimicrobials (antibiotics, antifungals, and antiviral agents), complicating optimal dosing strategies. This becomes even more complex in those receiving continuous renal replacement therapy (CRRT), as CRRT significantly alters drug clearance. Nonetheless, many pharmacokinetic studies exclude patients undergoing CRRT and existing studies often suffer from methodological limitations and small sample sizes, reducing their generalizability. Accordingly, there remains a critical gap in robust, evidence-based dosing guidelines for antimicrobials in ICU patients on CRRT, despite the clear clinical need.

Patients on haemodialysis are commonly treated with teicoplanin for Gram-positive infections. Kidney replacement therapy is known to alter drug pharmacokinetics, which impacts treatment success. This study aimed to characterise teicoplanin PK, explore potential covariate predictors for interindividual variability, and derive an evidence-based dosing strategy for patients undergoing maintenance haemodialysis.

Fluoroquinolones can exert excitatory effects on the central nervous system. Our population-based cohort study assessed whether fluoroquinolones are associated with an increased risk of seizures.

Multidrug-resistant organisms (MDROs) are becoming increasingly prevalent among patients with advanced cancer referred for palliative care (PC), and may adversely impact the quality of end-of-life care.

The objective of this study was to evaluate patient characteristics and clinical outcomes in cases of B. parapertussis compared with B. pertussis.

Despite advancements in shorter, oral regimens for drug-resistant tuberculosis, more options are needed to extent patient benefits. We conducted a trial to evaluate the non-inferiority of an all-oral regimen compared to the injectable-containing regimen.

Hepatitis A virus (HAV) remains a preventable cause of acute viral hepatitis, with an estimated 159 million new infections and 39,000 deaths in 2019. While improved care and hygiene reduced deaths, global incidence rose by ∼4%, driven by increased symptomatic cases and population growth. The availability of safe and highly immunogenic vaccines and the absence of chronic carriage make HAV uniquely amenable to global eradication.

Hierarchical composite endpoints (HCEs) are increasingly being used in infectious disease research. In this paper, we illustrate different methods for analyzing HCEs in post-hoc analyses of the BALANCE and CAMERA2 clinical trials.

Excess mortality during periods of respiratory virus circulation is very high compared to the number of reported deaths due to these infections. We aimed to estimate the prevalence of infection by influenza and other respiratory viruses in deceased persons during four influenza seasons.

Antibiotic resistance threatens effective infection treatment and medical procedures. Global initiatives, such as World AMR Awareness Week, aim to improve public understanding and promote rational antibiotic use to combat this growing crisis.

Invasive mould infection (IMI) is a major cause of morbidity and mortality in immunocompromised children. Outcomes for paediatric patients with IMI remain poor, due in part to the limitations of available diagnostic tools and therapeutic agents.