To estimate the number of cancer-related deaths that could be attributed to spatial disparities in survival.

Infertility affects about one in six couples and a male factor may contribute to 50% of cases. Until recently, no Australian-based clinical guidelines for the management of male infertility had been published. A panel of experts was assembled to formulate the first Australian evidence-based guidelines on male infertility.

Asthma is a chronic respiratory disease that affects more than 250 million people. It is a heterogeneous disease with a variety of symptoms, severity, and underlying mechanisms. Long term remission has been achieved for small subgroups of people with asthma treated with targeted biologic therapy. Accurately defining asthma subgroups is therefore of upmost importance for further reducing the prevalence of asthma. The rapid rise in technologies that enable profiling of a spectrum of analytes provides the opportunity to accurately classify asthma subtypes and to elucidate the underlying causes of disease. Combining these technologies with artificial intelligence will enable more accurate disease prediction, precision diagnoses, and personalised treatments. A major challenge is the prioritisation and effective implementation of these technologies in clinical practice.

Asthma affects more than 300 million people worldwide and is frequently associated with other medical conditions in adults, including chronic obstructive pulmonary disease, ischaemic heart disease, and stroke. Despite the huge burden, there has been little progress toward prevention and cure, possibly related to a one-size-fits-all approach. The recent identification of various asthma trajectories over the life course suggests that identifying biomarkers of lifetime transitions could advance progress to prevention and cure. This will require combining data, including for biological samples, from large cohort studies, for analysis using integrated computational biological approaches. We summarise key articles on Australian cohort studies that have characterised asthma trajectories across childhood and adulthood in order to inform research focused on curative approaches. Five Australian cohorts have provided information on childhood and adulthood asthma trajectories and their relationships with early life factors, later life outcomes, and underlying biological mechanisms. Twelve other cohort studies undertaken in Australia could also contribute valuable information. Australian asthma cohort studies have collected a wealth of information across the life course on the drivers, outcomes, and biological mechanisms of asthma. Integrating these resources into harmonised, functionally useful databases will make their data and biospecimens accessible for analysis and research. Australia is well placed for advancing progress in the prevention and cure of asthma.

To assess the feasibility of embedding omega-3 fatty acid testing and targeted supplementation (the Omega-3 Test-and-Treat Program) into routine antenatal care to reduce the risk of preterm birth.