Intimacy and Empowerment in Urogynecology: A Qualitative Exploration of Vibrator Use
To explore and describe the views and experiences of urogynecology patients with sexual dysfunction and pelvic floor disorders with scheduled vibrator use.
Identifying potentially modifiable risk factors associated with racially disparate postoperative outcomes following benign hysterectomy
Among patients undergoing hysterectomy for benign indications, Black patients experience higher rates of perioperative complications across both abdominal and minimally invasive surgical routes, and this disparity persists after adjusting for factors such as uterine weight, medical comorbidities, and other patient-level perioperative risk factors. Given the persistence of racial disparities, it is essential to identify potentially modifiable surgeon and hospital-level factors that may be contributing to the disproportionate morbidity experienced by Black patients. Literature regarding strategies to reduce racially disparate outcomes in benign hysterectomy is scant. With the exception of minimally invasive surgical approach and surgeon volume, racial disparities in access to perioperative clinical and surgical best practices has not yet been explored.
Single versus longitudinal scans in the third trimester: a multicenter randomized clinical trial on screening for late-onset intrauterine fetal growth restriction (The RELAIS Study)
Undiagnosed fetal smallness is strongly associated with adverse perinatal outcomes. Despite robust evidence that late third trimester ultrasound improves small for gestational age detection the question of whether routine ultrasound assessment in late pregnancy can improve perinatal outcome remains unresolved.
Laparoscopic trans-broad-ligament abdominal cerclage with round ligament suspension to create a space in the pouch of Douglas (LAC-D) during pregnancy
Cervical insufficiency is a major cause of second-trimester pregnancy loss and preterm birth. When transvaginal cerclage is ineffective or not feasible due to prior cervical surgery or a short cervix, transabdominal cerclage is a recognized alternative. However, performing transabdominal cerclage during pregnancy is more technically demanding than pre-pregnancy due to uterine enlargement and increased vascularity. An optimal approach minimizes contact with the pregnant uterus and avoids obstructing uterine artery flow. To meet these goals, we developed a laparoscopic technique called LAC-D (Laparoscopic trans-broad-ligament Abdominal Cerclage with round ligament suspension to create a space in the pouch of Douglas during pregnancy) during pregnancy. This method elevates the uterus naturally by suspending both round ligaments to the anterior abdominal wall for temporary transfixation, creating space in the pouch of Douglas without direct manipulation. This allows safe placement of the suture while maintaining uterine artery blood flow by ligating the cervix medial to the ascending uterine artery. The procedure was performed in 12 pregnant women, with no pregnancy losses. LAC-D might show promise as a minimally invasive and effective surgical option for cervical support during pregnancy, offering technical advantages and favorable outcomes.
Effectiveness of Tdap vaccination in pregnancy at preventing infant pertussis
Maternal vaccination with the tetanus, diphtheria, and acellular pertussis (Tdap) vaccine during pregnancy is the most effective way to prevent pertussis in infants, especially in the first few months of life before infants are eligible to receive the diphtheria, tetanus, and acellular pertussis (DTaP) vaccine. This study evaluated the effectiveness of Tdap vaccination in pregnancy in protecting infants against pertussis disease during the first 2 and 12 months of life.
Severe maternal morbidity and risk of adverse pregnancy, delivery, and neonatal outcomes in the subsequent delivery
Severe maternal morbidity (SMM) is associated with substantially increased risks of adverse neonatal outcomes. However, few studies have assessed the association between SMM and adverse pregnancy, delivery, and perinatal outcomes in the subsequent delivery.
Twin specific charts are more appropriate to assess fetal growth in twins (Reply to Letter-to-the-Editor)
Recommendations for penicillin allergy assessment in pregnancy (Letter-to-the-Editor)
Multigenerational smoking during pregnancy and risk of stillbirth: A population-based three-generation cohort study
Maternal smoking during pregnancy increases risk of stillbirth. Emerging evidence suggests that smoking in pregnancy may be related to health outcomes of a second generation, but the role of grandmaternal smoking on fetal survival of grandoffspring has not been studied.
Pregnancy Outcomes in Heart Transplant Recipients: A Systematic Review and Meta-Analysis of Maternal and Neonatal Morbidities
Advances in heart transplant (HT) have increased the number of reproductive-aged women with grafts considering pregnancy. However, this remains a high-risk scenario due to the potential for adverse outcomes. Current literature on comprehensive pregnancy outcomes and long-term graft implications remains limited OBJECTIVE: To evaluate maternal and neonatal outcomes of pregnancies in heart transplant recipients.
Discordant findings in genome-wide non-invasive prenatal testing (GW-NIPT) for rare chromosomal abnormalities, adverse pregnancy outcomes, and maternal malignancies: a systematic review and meta-analysis
Genome-wide non-invasive prenatal testing (GW-NIPT) has introduced new challenges in clinical interpretation, for example due to discrepancies between NIPT and confirmatory invasive results caused by confined placental mosaicism (CPM). These discordant cases often involve rare autosomal trisomies (RATs), frequently attributed to placental mosaicism. Complex, multi-chromosomal false-positive GW-NIPT results are usually not due to placental mosaicism, but rather to maternal malignancy, for example. This study aimed to assess chromosome-specific associations with pregnancy complications and uniparental disomy (UPD) in false-positive RATs, as well as the prevalence of maternal malignancies in complex, multi-chromosomal GW-NIPT results.
Variability of menstrual cycles by age, polycystic ovary syndrome, and early-life cycle irregularity in the Apple Women's Health Study
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, characterized by oligomenorrhea and androgen excess. Only a few studies have addressed the natural history of menstrual cycles among women with PCOS and/or irregular cycles, most with limited sample size and homogenous populations. We describe age-related differences in menstrual cycle length (MCL) and regularity for those with and without a diagnosis of PCOS.
The Impact of conception by IVF on Breastfeeding Initiation and Establishment Amongst Singleton Infants: A Statewide Cohort Study
Breastfeeding has many benefits for mother and child. Previous studies have suggested that breastfeeding is highly desired in pregnancies conceived through IVF, but that early breastfeeding cessation may be more common in this population. We aimed to study the effect of conception by IVF on breastfeeding initiation, use of formula in hospital, and rates of exclusive breastfeeding at time of hospital discharge.
Sublingual or Oral Versus Vaginal Misoprostol for Cervical Priming Prior to First-Trimester Surgical Abortion: A Systematic Review and Meta-Analysis
To compare the efficacy of oral or sublingual misoprostol versus the vaginal route for cervical preparation prior to first-trimester surgical abortion. This systematic review and meta-analysis assessed baseline cervical dilation, intraoperative blood loss, and operating time to guide clinical decision-making.
Systematic review of national and international clinical practice guidelines for management of preterm prelabour rupture of membranes
Preterm prelabour rupture of membranes (PPROM) is a common pregnancy complication and a major contributor to preterm birth, but lacks contemporary evidence to guide management. This systematic review aims to highlight the areas of consensus and inconsistency between international guidelines.
Early prediction of congenital cytomegalovirus infection and symptoms after maternal primary infection: an in vivo study using CMV-PCR in chorionic villi and in amniotic fluid
The long interval between serological diagnosis of maternal primary infection (MPI) at first trimester and prenatal diagnosis of fetal infection by amniocentesis from 17 weeks' may cause anxiety and distress. CMV-PCR in chorionic villi (CV) sampled by CVS at 14 weeks' can diagnose trophoblastic infection.
A critical review of placental function evaluation near term using Doppler ratios
The evaluation of placental function near term remains a cornerstone of perinatal care, yet subtle dysfunction often escapes detection through conventional Doppler indices of the umbilical artery and middle cerebral artery. In this context, Doppler ratios-particularly the cerebroplacental ratio (CPR) and the umbilicocerebral ratio (UCR)-have emerged as promising tools for enhancing sensitivity in identifying early signs of fetal adaptation to hypoxia. This Clinical Opinion critically examines the rationale, clinical relevance, and limitations of CPR and UCR as markers of placental insufficiency in the third trimester. CPR, which combines umbilical artery and middle cerebral artery impedance, has been shown to become abnormal before individual Doppler components, offering earlier recognition of compromised fetuses. Its use is supported in late-onset fetal growth restriction by several guidelines, including those of the International Society of Ultrasound in Obstetrics and Gynecology, though not by others such as the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine, which cite limited evidence of improved outcomes. The role of CPR in appropriately grown fetuses remains controversial; while associations with adverse perinatal outcomes have been observed, the performance of this ratio in routine screening for adverse perinatal outcomes in the third trimester has been found to be poor, and randomized trials have not demonstrated clinical benefit from delivery based on CPR alone. The current evidence is hindered by heterogeneity in CPR thresholds, lack of standardization in measurement timing, and potential confounding by clinical interventions aimed at reducing adverse outcomes. Furthermore, most studies fail to isolate the predictive value of CPR independently of abnormal umbilical artery or middle cerebral artery findings. While CPR and UCR may contribute to risk stratification in late-onset FGR, they should not currently be used in isolation to guide delivery timing. An ongoing trial is expected to clarify the role of UCR in guiding management decisions in late preterm fetal growth restriction. In the absence of growth restriction, routine assessment of these ratios in low-risk pregnancies may lead to unnecessary interventions without improving outcomes. However, when measured, abnormal ratios may still highlight increased risk and should be interpreted in conjunction with other ultrasound and clinical parameters.
Antenatal Corticosteroid Administration in Periviable Twin Pregnancies Between 22 and 25 weeks: A Nationwide-Based Study
Twin pregnancies are markedly increased risk of preterm birth, with a growing proportion delivering at periviable gestational ages. While antenatal corticosteroid (ACS) administration improves neonatal outcomes in singleton pregnancies, evidence specific to twins at the threshold of viability remains limited.
Association of Physical Activity and Sedentary Behavior with Urinary Incontinence in Adult Women: A Systematic Review and Meta-analysis of Observational Studies
To explore the association of physical activity and sedentary behavior with urinary incontinence in adult women.
Clarifying the Application of Exome Sequencing in Fetal Effusions (Letter-to-the-Editor)
Vaginal hysterectomy vs laparoscopic hysterectomy for benign indications: complications and length of stay in a national analysis of contemporary data
The current recommendation to select vaginal hysterectomy for benign indications whenever feasible is based on clinical trials with limited cohorts and older data.
