Metabolic dysfunction-associated steatotic liver disease (MASLD) primarily results from dysregulated lipid metabolism in hepatocytes. However, the mechanisms governing hepatic lipid metabolism remain incompletely understood. Our preliminary experiments demonstrated elevated expression of R-spondin 2 (RSPO2), a matricellular protein, in steatotic livers. Therefore, we investigated the role of RSPO2 in MASLD and potential underlying mechanisms.

Atezolizumab plus bevacizumab (A+B) is a standard first-line systemic therapy for unresectable hepatocellular carcinoma (HCC). However, optimal sequencing strategies after A+B failure remain undefined.

Tamponade is a bridge therapy for refractory variceal bleeding. This study compared esophageal stents (ESs) and balloon tamponade (BT) in terms of early bleeding control and mortality.

Liver transplantation (LT) to prevent cholangiocarcinoma (CCA) in individuals with primary sclerosing cholangitis (PSC) and bile duct dysplasia was introduced in Norway and Sweden in the early 2000s. We aimed to evaluate this practice to potentially improve future selection of candidates for LT.

Dysregulated bile acid (BA) homeostasis has been implicated in the initiation and progression of cholangiocarcinoma (CCA). The aim of this study was to investigate the roles of circulating and tumor BAs, oxysterols, short-chain fatty acids (SCFAs), transcriptomic changes, and stool microbiota composition in CCA, and their potential diagnostic and therapeutic implications.

Aging and alcohol misuse independently alter monocyte (MO) and macrophage (MØ) function, leading to impaired antimicrobial responses. However, how alcohol misuse contributes to impaired MO/MØ function during aging remains unclear.

Impaired phagocytic capacity due to activation of the PD-1/PD-L1 pathway has been implicated in the development of bacterial infections in patients with cirrhosis. Soluble PD-L1 (sPD-L1) is easily measurable in plasma and has been proposed as a biomarker of sepsis. In the current study, we aim to evaluate the role of sPD-L1 as a biomarker of bacterial infection development in patients with cirrhosis.

Several studies have shown that non-medical factors can determine access to liver transplantation (LT). Most of these studies are from North America, where the healthcare system has specific features that may not be generalisable to Europe. We investigated the factors associated with access to LT in patients admitted for a first episode of decompensated cirrhosis in France and to determine potential treatment gaps according to disease aetiology.

The correlation between systemic inflammation response index (SIRI) and both cardiovascular disease (CVD, including myocardial infarction and total stroke) and mortality in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. We examined this association in a large Chinese cohort.

Cholemic nephropathy (CN) is a severe complication of liver diseases associated with cholestasis and represents an unmet medical need. Recently, we identified the molecular mechanism of CN and showed that the systemic apical sodium-dependent bile acid transporter inhibitor (ASBTi) AS0369 prevented CN in mice. However, it is not clear if ASBTi is effective in a therapeutic rather than a preventive setting.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health issue. Identifying factors that prevent hepatic lipid accumulation could inform new MASLD prevention or treatment strategies. We previously demonstrated that adipocyte microsomal triglyceride transfer protein (MTP) regulates intracellular lipolysis by inhibiting adipose triglyceride lipase activity. The aim of this study was to investigate the impact of adipose MTP deficiency on MASLD.

Perihilar cholangiocarcinoma (pCCA) is a surgically challenging malignancy associated with a high risk of postoperative complications. However, advances in surgical techniques, perioperative care, and systemic therapy might have improved overall survival (OS) over time. This study investigated the evolving impact of failure-to-rescue (FTR) rates and oncological treatment strategies on outcomes in patients with pCCA after curative surgery.

Hepatocellular carcinoma (HCC) displays heterogeneous responses to lenvatinib, with tumor microenvironment (TME) stiffness emerging as a key resistance modulator. This study investigates how tumor peripheral stiffness governs lenvatinib efficacy via mitochondrial fission/mitophagy and evaluates matrix-targeting combination therapies.

N-methyladenosine (mA) modification regulates mRNA stability and translation to promote cancer progression. FK506-binding protein 9 (FKBP9), a peptidyl-prolyl isomerase, is associated with carcinogenesis, but its role in mA modification remains unclear. In this study we aimed to explore how FKBP9 regulates mA modification during the development of hepatocellular carcinoma (HCC).

Advances in digital pathology and artificial intelligence (AI) are driving progress toward personalized clinical management. In hepatocellular carcinoma (HCC), AI-based models using digitized H&E slides can be a robust tool to predict outcome-related molecular profiles and presence of microvascular invasion (mVI), with potential clinical utility.

Yes-associated protein (YAP) impairs hepatocyte regeneration in alcohol-related hepatitis (AH), but its impact on fibrogenesis remains to be characterized. Our aim here was to describe fibrogenesis and investigate the impact of altered hepatocytes on fibrogenic mechanisms during AH.

Chronic HBV infection is a leading cause of liver disease and cancer. Current therapies fail to eliminate covalently closed circular DNA (cccDNA), underscoring the need for novel strategies. We aimed to develop a quantitative cell-based reporter system that detects HBx expression during HBV infection and is suitable for screening compounds with anti-HBV activity.

Hepatitis A virus (HAV) remains a significant public health threat. The HM175-mp4-based mouse model has advanced pathogenesis research, but its slow replication limits reverse genetic studies. We aimed to develop a genetically tractable HAV model through rational mutagenesis.

Drug-induced liver injury (DILI) is a complex condition often linked to medication behaviors, with patient education having a crucial role in optimizing outcomes. Large language models (LLMs) could serve as promising tools for scalable patient support, but their utility remains unclear. This study systematically evaluated the capability of six popular open- and closed-source LLMs in addressing common DILI-related queries, focusing on patient-centered education.

The glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) has emerged as a vital oncogene in many cancer types as a result of its metabolic function and signaling pathways. However, the effects of alternative splicing variants of PFKFB4 remain largely unexplored.

Transient elastography (TE) can be used to accurately screen for severe liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). However, some studies suggest that steatosis influences liver stiffness measurement (LSM). Thus, treatment that modifies steatosis might impact the relevance of TE in the management of patients. The use of magnetic resonance imaging (MRI)-proton density fat fraction (PDFF) has shown good reliability and accuracy for quantifying hepatic steatosis. Therefore, the aim of our study was to evaluate the performance of TE combined with MRI-PDFF for the diagnosis of severe fibrosis in patients with MASLD. The study is registered at ClinicalTrials.gov (NCT03245606).