Circulation-Cardiovascular Imaging

Not All Prognostic Tools Are Equal: A Sex-Specific Approach to ASCVD Primary Prevention
Jowell AR and Shah NP
Global Longitudinal Strain for Prognostic Staging in Wild-Type Transthyretin Cardiac Amyloidosis
Debonnaire P, L'Hoyes W, Donal E, Verheyen N, Vervloet D, Dujardin K, Pouleur AC, Dulgheru R, Sarli Issa V, Droogmans S, Jurcut R, Regeer M, Dupont M, Bondue A, Timmermans P, Bohyn A, Christiaen E, Wyseure N, Bezard M, Zach D, Schwegel N, Knapen R, Buytaert L, de Marneffe N, Adam R, Ajmone Marsan N, Tavernier R, Buysschaert I and Trenson S
A formal prognostic staging system in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), based on echocardiographic imaging, is lacking. We evaluated the prognostic performance of global longitudinal strain (GLS) staging in a large ATTRwt-CM patient cohort, including under tafamidis treatment and relative to National Amyloidosis Center (NAC) biomarker staging.
Function Follows Form: The Relationship Between Right Ventricular Shape and Adverse Outcomes in Patients With Hypoplastic Left Heart Syndrome
Friedberg MK and Wald RM
Spectral Dual-Layer CT Identifies Key Diagnostic Features in Stress Cardiomyopathy
Herrera-Flores C, Sánchez-Puente A, Braccho-Braccita D, Maillo-Seco J, López-Jiménez RA, Martín-García A, Rodríguez-Nieto J, Nieto-García L, González-González L, Rincón LM, Sánchez PL and Pérez Del Villar C
Myocardial Perfusion Imaging in Patients After Coronary Artery Bypass Grafting: Should We Go With the Flow?
Hyafil F and Mikail N
Minimally Invasive Diagnosis of a Cardiac Mass: Resolving Clinical-Imaging Discordance
Wanderley MRB, Asnani AH, Albayouk E, Kunamalla A, Ahmed M, Laham R, Towery EA, VanderLaan PA, Upshaw JN and Hoeger CW
Novel Echocardiographic Staging Classification for Cardiac Damage in Chronic Aortic Regurgitation
Pugliesi GM, Farrugia SL, Michelena HI, Scott CG, Pislaru SV, Kane GC, Padang R, Pellikka PA and Anand V
Chronic aortic regurgitation (AR) is associated with significant cardiac remodeling, but the prevalence and prognostic impact of extravalvular cardiac damage remain unexplored.
Entropy in Hypertrophic Cardiomyopathy: A New Layer in Risk Stratification for Sudden Cardiac Death
Lee C and Abraham TP
Relative Flow Reserve and 18F-Flurpiridaz: Help, Hype, or Harm in Clinical Cardiac PET?
Gould KL, Roby A and Johnson NP
Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans
Silickas J, Smith A, Andia ME, Botnar RM, Modarai B, Karunanithy N, Patel AS, Black S, Saha P and Phinikaridou A
Randomized trials of venous thrombolysis to prevent postthrombotic syndrome have produced mixed results. A method to identify patients most likely to benefit from interventional treatment is needed. This study evaluated a contrast-free, magnetic resonance-based multisequence thrombus imaging (MSTI) technique to characterize deep venous thrombi and predict susceptibility to thrombolysis.
Shape Variations in RV 3D Geometry Are Associated With Adverse Outcomes in Hypoplastic Left Heart Syndrome Patients: A Fontan Outcomes Registry Using CMR Examination (FORCE) Study
Loke YH, O'Hara R, Contento J, Marella N, Kollar S, Vegulla R, Gaviria S, Mehta R, Balaras E, Fetch A, d'Udekem Y, Alsaied T, Olivieri L, Truong U, Anwar S, Rathod RH, Capuano F and
Assessment of the systemic right ventricle (RV) is critical for patients with hypoplastic left heart syndrome (HLHS). Traditional imaging metrics fail to capture the RV's complex geometry and remodeling in HLHS, limiting risk stratification. We aimed to apply statistical shape modeling to a large multicenter cohort of cardiac magnetic resonance data sets to define RV shape variants and evaluate associations with clinical outcomes.
Healthy Training Versus Unhinged Straining: A Cautionary Tale
Quinaglia A C Silva T and Matos-Souza JR
Coronary Microvascular Dysfunction and Myocardial Fibrosis: A Tomographic Look at a Hidden Entity
Magalhães TA
Machine Learning Model for Atherosclerosis Evaluation and Cardiovascular Risk Prediction Based on Coronary CT Angiography-Analysis From the CREATION Registry
Song Y, Xu N, Zheng J, Jia S, Cui C, Zhang Y, Gao L, Gao Z, Chen J, Song L, Yuan J, Lu B and Zhi-Hui H
Current ASCVD risk prediction tools based on traditional risk factors and the coronary artery calcium score have limitations.
Seeing the Unseen: Contrast-Free MRI for Predicting Thrombolytic Susceptibility
Dai L and Zheng J
Mental Stress, Significant Sex Differences, and the Substrate for Cardiovascular Disease: Early Insights From CMR
Hays AG and Kelle S
2025 ACC/AHA/ASE/ASNC/SCCT/SCMR Advanced Training Statement on Advanced Cardiovascular Imaging: A Report of the ACC Competency Management Committee
Baldassarre LA, Mendes LA, Blankstein R, Hahn RT, Patel AR, Russell R, Abbara S, Ahmad SM, Brady MB, Bullock-Palmer RP, Cavalcante JL, Chareonthaitawee P, Chen T, Clark DE, Conaway DG, Daubert MA, Day J, Di Carli MF, Galazka P, Gallegos-Kattán C, Herrmann H, Ho EC, Jellis CL, Le VT, Lema PC, Litmanovich DE, Little SH, Liu JE, Lopez-Mattei JC, Lumsden AB, Malaisrie SC, Melduni RM, Nieman K, Nikravan S, Ordovas KG, Parwani P, Patel KK, Phoubandith DR, Punnoose LR, Rybicki FJ, Sensakovic WF, Shapiro MD, Sperry BW, Spragg D, Tong MS, Vogel-Bass E, Volgman AS, Waheed A, Weissman G and Wells BJ
Utility of F-Flurpiridaz PET Relative Flow Reserve in Differentiating Obstructive From Nonobstructive Coronary Artery Disease
Lopez DM, Huck DM, Divakaran S, Brown JM, Weber BN, Lemley M, Builoff V, Shanbhag A, Lan Z, Buckley C, Al-Mallah MH, Dorbala S, Blankstein R, Slomka P and Di Carli MF
Absolute quantification of myocardial blood flow (MBF) on positron emission tomography perfusion imaging improves the identification of coronary artery disease (CAD). However, distinguishing MBF impairment due to obstructive CAD from nonobstructive CAD remains challenging. We aimed to evaluate the incremental diagnostic value of positron emission tomography derived relative flow reserve (RFR) in the diagnosis of obstructive CAD.
Sex Differences in the Relationship Between Psychosocial Stress and Myocardial Tissue Characteristics: A CMR Imaging Study
Moukarzel M, Soroush K, Zhang Y, Gouin JP, Friedrich MG and Luu JM
Psychosocial stress is linked to the development of cardiovascular disease, with a more pronounced impact in female participants. This study investigates sex differences in the association between perceived stress and myocardial tissue characteristics, as assessed by cardiovascular magnetic resonance imaging, and evaluates the contribution of psychosocial burden, including caregiving and perceived social standing.
Sex-Specific Prognostic Differences Between CACS and Lp(a) in Atherosclerotic Cardiovascular Disease Events: The MESA Study
Xue R, Liu J, Wang H, Wu X, Ma M, Zhu Y, Wen D and Zheng M
Lp(a) (lipoprotein [a]) and coronary artery calcium score (CACS) are independently associated with atherosclerotic cardiovascular disease (ASCVD) risk. This study aimed to investigate sex-specific prognostic differences between Lp(a) and CACS in ASCVD risk.
Prognostic Utility of Quantitative Perfusion PET in Patients With Prior CABG: Incremental Value of Myocardial Flow Reserve and Coronary Vascular Resistance
Kadoya Y, Da Silva E, AlTakroni L, Hejji N, Boczar KE, Chow B, deKemp R, Ruddy TD, Beanlands R and Small GR
The prognostic utility of quantitative positron emission tomography (PET) with myocardial blood flow (MBF) measurements in patients with prior coronary artery bypass grafting remains unestablished. We evaluated PET-derived myocardial flow reserve (MFR) and coronary vascular resistance (CVR) for risk stratification in coronary artery bypass grafting patients.