To better understand how patient-specific alterations in the synovial fluid composition and its viscosity affect cartilage friction of samples with mild and advanced signs of degeneration.

Placebo response (PR) presents a significant challenge in osteoarthritis (OA) trials. Screening Period Pain Inconsistency (SPPI) has been associated with heightened PR in placebo-treated patients. However, existing studies have overlooked whether increasing versus decreasing pain during the screening period affects this relationship differently. This study examines the impact of SPPI magnitude and direction on PR.

To investigate the associations between whole joint cartilage and meniscal morphology on MRI and radiographic joint space width (JSW) measures and in knee osteoarthritis (KOA), to determine whether bicompartmental measures demonstrate stronger associations than unicompartmental ones, and to evaluate their correlations with Kellgren and Lawrence grading.

To examine the causal association between obesity and osteoarthritis (OA) using an improved definition of obesity, and to identify mediating genes that may link obesity to OA pathogenesis.

To conduct a narrative review of selected imaging studies published in the past year, with a focus on how emerging methods and multi-tissue assessments are contributing to disease characterization, early detection, and intervention strategies.

To investigate the distinct roles of microRNA-140 (miR-140) in skeletal development and osteoarthritis (OA), and to identify novel miR-140-5p targets using advanced transcriptomic profiling.

Metformin, a first-line treatment for type 2 diabetes, attenuates hallmarks of aging and protects against age-related diseases, including osteoarthritis (OA). Here, we assessed the effects of imeglimin, a novel antidiabetic agent related to metformin, on the development and progression of knee OA.

To systematically identify the literature surrounding weight management (WM) integration into physiotherapist-led osteoarthritis (OA) care and understand the perceptions of physiotherapists, students and people with OA towards physiotherapist-led WM within OA care.

Transforming growth factor-β1 (TGF-β1) signaling is critical in joint homeostasis and osteoarthritis (OA) pathogenesis. Engedi 1000 (E1K), a novel short peptide, is a selective modulator of TGF-β1-induced SMAD1/5/9 signaling. We evaluated the analgesic and structure-modifying effects of E1K in OA models.

The trapeziometacarpal (TMC) joint, a common site of osteoarthritis (OA) in postmenopausal women, relies on ligamentous structures for stability due to minimal bony constraint. However, the role of ligamentous constraint in OA pathomechanics, specifically its relationship with joint kinematics and surface morphology across disease stages, remains poorly understood.

This study compared the predictive validity of three-dimensional joint space width (3D-JSW) on weight-bearing computed tomography (WBCT) versus two-dimensional joint space width at predetermined mediolateral locations (2D-JSW) on radiographs for worsening knee pain and physical function over 24 months.

This review aims to assess the existing evidence that connects osteoarthritis (OA) with neurodegenerative diseases, specifically Alzheimer's disease (AD) and Parkinson's disease (PD), and to elucidate shared mechanisms that may contribute to the development of innovative therapeutic approaches.

This year in review (1) narratively synthesises the effect of, or patient experience with, non-pharmacological or non-surgical rehabilitation treatments for osteoarthritis at any joint; and (2) describes how sex and/or gender are defined, reported, and analysed. We searched three databases (Medline, Embase, CINAHL) for studies that met predefined criteria and selected those of perceived moderate-to-high quality and importance published between 12th March 2024 and 1st March 2025. Studies were grouped according to predominant treatment topic areas (e.g. core [exercise, diet]; adjunct [electrotherapy, manual therapy]; multimodal [different rehabilitation treatments]). Two authors independently screened records. One author extracted data, and another checked 10% of the accuracy. Full-text screening identified 158 eligible studies, reduced to 39 for synthesis. We identified eight themes: i) Exercise is effective for knee osteoarthritis and comorbidities, but has varied effects for hip osteoarthritis; ii) Diet plus exercise is effective for weight loss, but may not reduce pain; iii) Digital rehabilitation is a viable alternative to in-person care; iv) No added benefit of mind/behavioural treatments; v) Effects of electrotherapy modalities on pain were inconsistent and region-specific; vi) Orthoses may relieve pain, but should be individualised to patient preferences; vii) Acupuncture and blood flow restriction treatment show effectiveness in single clinical trials; viii) Treatment packages for osteoarthritis have varied benefits. Sex and gender were reported in 23 and 11 studies, respectively. For gender, most studies used female/male/woman/man interchangeably. No study defined sex or gender, 5% reported results disaggregated by sex or gender, no study justified why results were not, and 5% summarised key sex or gender findings.

Cartilage endplate (CEP) is one of the most important components of the functional unit of the spine, and its performance is closely related to mechanical compression. N4-acetylcytidine (ac4C) modification, a recently identified RNA modification, is implicated in the onset and progression of numerous diseases. This study aimed to investigate the role and mechanism of ac4C modification in the process of CEP degeneration induced by excessive compression.

To identify the presence and magnitude of total joint arthroplasty (TJA) disparities in length of stay (LOS).