We read with considerable interest the article by Beunders et al. (2025) titled "Physical multimorbidity is not independently associated with cognitive performance in patients with older-age bipolar disorder (OABD)" published in International Psychogeriatrics. The study addresses an important and underexplored area, highlighting the complex interplay between multimorbidity and cognition in OABD. While the authors conclude that physical multimorbidity is not independently associated with cognitive impairment after adjustment for confounders, we believe some methodological and conceptual aspects warrant further reflection.

An emerging body of work suggests that financial exploitation vulnerability (FEV) may be an early marker of Alzheimer's disease (AD). We examined how APOE e4 genotype and cognition at baseline interact to predict subsequent FEV one year later. Participants were 95 older adults without dementia aged 50 or older (M age = 69.09, SD = 7.51; 72.63 % female; 72.63 % White non-Hispanic). Participants completed two annual assessments that included comprehensive neuropsychological testing and a measure of FEV. Saliva samples for APOE genotyping were collected. Linear regression models regressed Year 2 FEV on APOE, global cognition, and their interaction. Age, sex, education, and Year 1 FEV scores were covaried. Models were re-run considering cognitive domains separately (memory, language, and attention/working memory and executive functioning). Main effects of APOE and cognition were not found. However, cognition and APOE status interacted to predict Year 2 FEV. Specifically, worse cognitive functioning predicted higher FEV only for e4 carriers. Cognitive domain analyses revealed more nuanced relationships. Findings suggest that cognition is a relevant risk factor of FEV for e4 carriers, and support the emerging idea that FEV may be an early marker of AD-related neuropathological changes.

The prevalence of mild cognitive impairment (MCI) has increased among older adults in recent years, while increasing evidence highlighted residence as a critical social determinant of cognitive health. This study examined the longitudinal association between residential trajectories and MCI, and whether depressive symptoms influenced these associations.

To understand the relationship between social determinants of health (SDoH) and neuropsychiatric symptoms (NPS) of dementia and mild cognitive impairment (MCI) such as depression, agitation, psychosis, and apathy.

Depression in older adults often goes undiagnosed due to subtle symptoms. Physical performance tests, established health markers, may help assess links between mental and physical health. This study examined 7-year changes in Geriatric Depression Scale (GDS) scores in relation to physical performance, considering sex differences.

Bipolar disorder is a lifelong mental disorder. Late diagnosis increases treatment difficulty and costs, and age-related decline in liver and kidney function may affect drug metabolism and efficacy. This study assesses the global disease burden, geographical distribution, influencing factors, and future trends from 1990 to 2021.

Little is known about the psychosocial pathways linking social support to health-related quality of life (HRQoL) in family caregivers of people with dementia (PwD). This study aimed to explore how self-efficacy and caregiver distress mediate the relationship between social support and caregivers' HRQoL.

Electroconvulsive therapy (ECT) is one of the most effective options for severe psychiatric disorders. However, it is often underutilized due to stigma and fear of cognitive side effects. This is the first systematic review and meta-analysis synthesizing the currently available evidence regarding ECT exposure and dementia risk.

A reduction in an aging individual's abilities combined with environmental changes can lead to decline in everyday function. This study examined the association between visual and cognitive abilities with everyday function and assessed whether measures of Social Determinants of Health (SDoH) moderate the associations of these predictors with activities of daily living (ADLs) and instrumental activities of daily living (IADLs).

Dementia and sleep disturbance co-occur frequently. Previous research has focused on sleep disturbance and dementia risk, but its impact in established dementia is less clear. The aim of this study was to investigate the frequency of recorded sleep disturbance at the time of dementia diagnosis and its association with adverse outcomes.

The proportion of older people is growing dramatically, implying that predictors of health-related quality of life (HRQoL) in older adults are of major interest within public health research.

The aging of the world's population has led to a growing need for innovative strategies to promote active aging and bridge generational divides. Intergenerational Programs (IGPs) that engage young adults (18-30 years) and older adults (65 + years) have demonstrated the potential to improve well-being and reduce ageism. However, the evidence for this pairing of ages is still fragmentary. This review aims to provide a qualitative and systematic synthesis of present IGPs, deepening the main characteristics of their implementations.

As demand for mental healthcare access grows among older adult populations, digital mental health tools have emerged as promising tools. However, bridging the digital divide among older technology users remains critical. This post-hoc analysis evaluated potential factors influencing the adoption of a digital mental health tool in older adults.

This scoping review provides an overview of narrative approaches used to collect experiences of older persons in long-term care and how these approaches support learning and quality improvement.

Quilombos are settlements founded by descendants of runaway enslaved populations in Brazil, and often present social vulnerabilities, high levels of illiteracy, and limited health access. The Quilombola population likely presents an increased risk for dementia; however, it is underrepresented in aging research. This study aimed to investigate the association between cognition and social participation, which remains unclear in underserved communities.