Folenolide, a novel compound, was investigated for its pharmacological potential, focusing on its analgesic, anti-inflammatory, and antipyretic effects, along with its safety profile and potential molecular targets, using and molecular docking studies.

Antithrombotic management in Chronic Kidney Disease (CKD) is a clinical dilemma. This study aimed to empirically evaluate the " interchangeability" of the antiplatelet indobufen and the anticoagulant rivaroxaban by comparing their real-world effectiveness and safety in hospitalized CKD patients.

This study aimed to characterize time-dependent metabolic alterations and identify metabolites associated with treatment response in HER2-negative breast cancer patients undergoing neoadjuvant chemotherapy (NAC) with the TEC regimen (docetaxel, epirubicin, and cyclophosphamide).

Anticholinergic medications frequently cause hyposalivation (decreased saliva flow) through parasympathetic inhibition. This adverse effect is related to anticholinergic burden, reflecting the cumulative exposure to drugs with anticholinergic properties. Genetic variation in CYP genes, which encode drug-metabolizing enzymes, alters drug metabolism, potentially influencing systemic anticholinergic burden. This study investigated whether polymorphisms in the and genes are associated with anticholinergic burden and hyposalivation.

This study aimed to investigate the therapeutic effects and action mechanisms of polysaccharides (ASP) on a chemotherapy-induced premature ovarian insufficiency (POI) rat model along with screening for the optimal therapeutic dose.

This study aims to investigate the effect of exosomes derived from Panax notoginseng on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) and to elucidate the underlying intracellular signaling mechanisms.

Metformin shows promise in preventing colorectal cancer (CRC) and its precursors, but evidence on its dose-response effect remains limited.

Metabolic and gut microbiota (GM) disturbance play a significant role in the complex pathogenesis of substance dependence. Although levo-tetrahydropalmatine (l-THP) demonstrates therapeutic potential in drug addiction, the underlying mechanism remains elusive.

To evaluate the cost-utility of different dosing regimens of PCSK9 inhibitors, added to statin therapy, in patients with hypercholesterolemia or at high cardiovascular risk in China.

Functional dyspepsia (FD) has a global prevalence of approximately 15% and is characterized by chronic symptoms with an unclear etiology. Herbal medicines, owing to their multifaceted mechanisms, are promising therapeutic options for FD. This study aimed to establish medical evidence for the use of Sihogyeji-tang (SG), a herbal medicine, in the treatment of FD, thereby providing clinically relevant evidence for both patients and healthcare practitioners.

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with oxidative stress and ferroptosis, leading to liver injury and fibrosis. Garlic, renowned for its antioxidant and hepatoprotective properties, is commonly used in traditional medicine. Ultrafine powder technology enhances the physicochemical properties of natural products, improving their bioavailability and efficacy. This study explores the protective effects of ultrafine garlic powder (UGP) on NASH and its underlying mechanisms.

Sufentanil-induced cough (SIC) is prevalent in anesthesia practice. A variety of interventions have been employed to prevent SIC. However, the optimal intervention remains elusive.

Methotrexate is a potentially toxic antifolate antineoplastic and immunosuppressive agent that is widely used in tumor chemotherapy and autoimmune diseases (such as psoriasis). It is the cornerstone therapy for immune-mediated disorders worldwide. However, low-dose methotrexate therapy for psoriasis rarely causes toxicity. Here, we report a case of a patient with psoriasis who was treated with low-dose methotrexate for the first time. The patient developed severe mucosal ulcers and myelosuppression, leading to impaired immunity and invasive pulmonary mucormycosis. After treatment, the patient recovered and was discharged. It demonstrates that even low-dose methotrexate prescribed for psoriasis can induce severe toxicity. The case highlights the potential for low-dose methotrexate toxicity, suggesting that genetic polymorphisms may increase the risk of toxicity. The influence of genetic polymorphisms on methotrexate metabolism is highly variable. It is important to strengthen early monitoring in clinical practice, improve toxicity prediction models, and establish risk assessment systems for toxic drugs.

We aimed to study the pharmacokinetics (PK) of mycophenolic acid (MPA) in plasma and peripheral blood mononuclear cells (PBMCs) and the relationship of MPA in plasma and PBMC with activity of inosine monophosphate dehydrogenase (IMPDH) in Chinese kidney allograft recipients.

The evolving landscape of artificial intelligence in drug discovery necessitates increasingly sophisticated approaches to predict drug-target interactions (DTIs) with high precision and generalizability. In alignment with the current surge of interest in AI-driven pharmacological modeling and integrative biomedical data analysis, this study introduces a multimodal framework for enhancing DTI prediction by fusing heterogeneous data sources. While conventional methods typically rely on unimodal inputs such as chemical structures or protein sequences, they fall short in capturing the complex, multi-faceted nature of biochemical interactions and are often limited in adaptability across different tasks or incomplete datasets. These limitations impede the model's capability to generalize beyond narrow benchmarks and reduce interpretability when modalities are missing or noisy.

This study aimed to elucidate the molecular mechanisms by which celastrol (Cel) alleviates atherosclerosis (AS) through the regulation of macrophage autophagy.

Medical thoracoscopy (MT) is increasingly performed under local anesthesia with sedation, yet suboptimal analgesia and discomfort remain common and may compromise patient safety, cooperation, and recovery. Ultrasound-guided thoracic paravertebral block (TPVB) provides targeted, long-lasting analgesia, while dexmedetomidine offers cooperative sedation with minimal respiratory depression. Evidence for their combined use in MT is limited. This study evaluated the perioperative efficacy and safety of TPVB plus dexmedetomidine compared with conventional local anesthesia and sedation.

Acute myeloid leukemia (AML) is paradigmatic for therapeutic resistance driven by genetic heterogeneity, epigenetic plasticity and microenvironmental protection. Over the past decade, six targeted or pathway-directed small molecules-midostaurin, gilteritinib, quizartinib, ivosidenib, enasidenib, venetoclax and glasdegib-have changed frontline and relapsed/refractory (R/R) practice in genomically defined subgroups or in patients unfit for intensive chemotherapy. Yet primary refractoriness and early relapse remain common, frequently adaptive rewiring of apoptotic dependencies, clonal evolution and differentiation resistance. Here we integrate mechanistic insights with clinical evidence to: (i) map resistance biology onto targetable nodes (apoptosis control; signalling kinases; chromatin/lineage programmes; RNA splicing; DNA-damage response; nuclear export; niche adhesion and innate immune evasion); (ii) summarise the clinical trajectory and current limits of approved and emerging small molecules (including menin and LSD1 inhibitors); (iii) propose rules for rational doublets and triplets that are biologically orthogonal yet clinically tolerable; (iv) outline a regulatory timeline for key AML small molecules; and (v) prioritise where drug development should go next, including next-generation BH3 toolkits, clonal-pressure-aware designs, minimal residual disease (MRD)-adapted trials and therapy guided by dynamic functional profiling. The review closes with cross-platform challenges-myelosuppression, infectious risk, resistance monitoring and trial design-and a pragmatic framework for moving beyond incrementalism toward durable control and cure.

To serve as a clinical reference, we conducted a meta-analysis to assess and compare the efficacy and safety of combining Chinese herbal injections (CHIs) with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for treating advanced EGFR-mutated non-small cell lung cancer (NSCLC).

Melanoma remains a highly aggressive malignancy with limited therapeutic options targeting its underlying pathogenesis. CircPIAS1 (circbase ID: hsa_circ_0008378) and its encoded protein circPIAS1-108aa contribute to tumor progression by suppressing phosphorylation and immunogenic ferroptosis, yet specific pharmacological agents of directly targeting circPIAS1 are lacking. This study aimed to identify natural products that selectively inhibit circPIAS1 biogenesis, there-by exploring novel therapeutic strategies for melanoma.