Maternal nutrition during pregnancy is key for offspring neurodevelopment. Given the role of glucose in brain function, assessing carbohydrate quantity and quality, including glycemic index (GI), glycemic load (GL) and carbohydrate quality index (CQI), may provide insights into early brain development. This study examined the associations between maternal dietary carbohydrate intake and neurodevelopmental outcomes in early childhood.

A growing body of evidence suggests diets rich in flavonoids may protect against metabolic-dysfunction associated steatotic liver disease (MASLD) development and progression. As the gut microbiome is important in the biotransformation of flavonoids to their constituent bioactive metabolites, studies on the potential mediating role of the gut microbiome in the association between dietary flavonoid intakes and MASLD are warranted but lacking. Thus, this study aims to examine the associations between a diet rich in flavonoids and MASLD, and assess the potential mediating role of the gut microbiome.

Improving human and planetary health is one of the most important challenges of the current century. Demand-side food policy strategies can be implemented to achieve this dual objective. To develop and implement policy measures effectively, it is essential to conduct upfront analyses that demonstrate their potential impact.

To reduce the risk of recurrent cardiovascular events in patients with established cardiovascular disease (CVD), guidelines recommend adopting a more plant-based diet. The EAT-Lancet diet, which focuses on plant-based foods, is associated with a lower risk of CVD in apparently healthy people. However, the relationship in patients with established CVD is unclear. Therefore, the aim of this research was to quantify the relationship between the EAT-Lancet Healthy Reference Diet (HRD) and risk of recurrent CVD in patients with established CVD.

One-carbon metabolism (OCM) nutrients are essential for methylation processes and may be involved in the pathogenesis of rheumatoid arthritis (RA), but prospective evidence remains limited. This study aimed to investigate the association between dietary OCM nutrients and RA risk, and their interactions with genetic and lifestyle factors.

Although recent studies suggest associations between temporal meal patterns, diet quality, and health outcomes such as obesity and cardiometabolic risk, the evidence remains inconclusive, highlighting the need for further investigation. This study aimed to evaluate meal patterns, including meal frequency, breakfast skipping and timing of energy intake (late or early), and their associations with diet quality and body mass index.

A ketogenic diet (KD), high in fat and low in carbohydrates, induces ketosis characterized by elevated circulating ketone bodies. While both KD and ketone bodies have demonstrated therapeutic potential in various pathophysiological conditions, their effect on inflammatory bowel diseases remains controversial. This study aimed to investigate the impact of a KD and ketone ester (KE), an ingestible form of ketone bodies, on intestinal inflammation.

Legumes are promoted as climate-friendly and healthy protein sources. This study evaluated the association between replacing red and processed meat, poultry, or fish with equal amounts of legumes and the risk of gallbladder disease.

Interest in plant-based protein in the UK is increasing due to health, environmental, and ethical considerations. Recent studies have explored how different protein sources impact satiety and related gut hormone responses, with evidence suggesting varied responses between animal-based and plant-based proteins. Skewed protein intake patterns, especially at breakfast, present an opportunity for improving dietary protein distribution in populations who may require increased protein intake but often face appetite reductions. This study determined the acute effect of consuming a plant-based, high protein drink containing 30 g of protein (HPDp); an animal-based, high protein breakfast containing 30 g of protein (HPBa); and a low-protein (10 g), high-carbohydrate breakfast (HCLPB) on satiety hormone responses, subjective appetite and subsequent energy intake in older and younger populations when consumed at breakfast. Eighteen heathy adults completed this within-subject, counterbalanced, cross-over study, (12 under 35 years of age and six over 65 years of age). Measurements for appetite were obtained at baseline, 30, 60, 90, 120, 150, 180, 210 and 240 min, and plasma, GLP-1 and PYY at baseline, 30, 60, 90, 120, 180 min post breakfast consumption. No difference in appetitive responses was found between the HPDp and the energy- and protein-matched HPBa, with both eliciting greater GLP-1 and PYY (both p < 0.004) responses compared with a high carbohydrate, low protein meal. Subjective appetite was also suppressed to a greater extent with HPDp compared with HCLPB (p = 0.001). No differences were observed in ad libitum energy intake.

With the growing demand for sustainable and high-quality protein sources, evaluating their digestibility and amino acid availability is essential for human nutrition. The objective of this study was to assess the digestibility and Digestible Indispensable Amino Acid Score (DIAAS) of two novel protein sources, barley protein concentrate (BPC) and corn protein concentrate (CPC), using a minipig model as a proxy for human digestion METHODS: A T-cannulated minipig model (n = 6) was employed in a crossover design to measure standardized ileal amino acids (AA) digestibility and calculate DIAAS values, following Food and Agriculture Organization (FAO) guidelines. Each protein source was tested alongside a protein-free diet to estimate basal endogenous AA losses.

Plate-clearing behavior (PCB), a maladaptive behavior in a food environment characterized by large, energy-dense portions of food, may contribute to weight gain over time. If a portion size is selected that causes overeating, a trade-off exists between food waste and weight gain due to PCB. However, patterns between PCBs and pre-meal portion planning to prevent overeating (PPP-O) remain overlooked. This study aimed to identify these patterns in various meal situations and describe the demographic, anthropometric, psychological, and lifestyle-related characteristics of those following each pattern.

The Paleolithic Diet Fraction (PDF) estimates the proportion of absolute dietary intake derived from food groups included in the Paleolithic diet. In the Malmö Diet and Cancer Study (MDCS), higher PDF and lower systemic low-grade chronic inflammation (SLGCI) have been associated with lower cardiometabolic morbidity and mortality. We examined associations between PDF and SLGCI in the MDCS.

Dietary intake plays a pivotal role in sustaining optimal melatonin levels, while the relationship between dietary patterns and circulating melatonin levels remains unclear. This study aims to investigate the associations between dietary patterns, nutrient intake, and serum melatonin levels in the Chinese population.

Odd-chain saturated fatty acids (SFAs) have shown potential metabolic benefits, may exert protective metabolic effects. However, their association with MetS and the potential role of insulin resistance remains unclear.

Healthy and sustainable diets promote individual health and well-being while minimizing environmental impact. Although the concept of sustainable diets has gained increasing attention, the extent to which nutritional adequacy aligns with overall dietary sustainability remains unclear, particularly in the Portuguese context, where dietary patterns reflect both Mediterranean and Western influences. The study aims to assess the association between sustainable and healthy diet adherence and nutritional adequacy among Portuguese adults.

In the UK, more than half of the food supply is composed of ultra-processed foods (UPF). However, the association between UPF intake and osteoporosis risk remains unclear. This study aimed to investigate this association and explore potential mediating biomarkers.

This study aimed to establish trends in overweight and obesity prevalence among adults living in Ireland (18-64 years) and older adults (> 65 years) over three decades, from 1990 to 2024.

Added sugars are now acknowledged as a risk factor for obesity, insulin resistance, and purine degradation pathways. However, there has been limited evidence on the association between added sugars and hyperuricemia. Therefore, we designed a cohort study to examine whether added sugar intake increased the risk of hyperuricemia in Chinese adults.