This study investigated associations between weight-related impairment (WrI), degree of overweight/obesity, and health-related quality of life (HrQoL) in children and adolescents with overweight or obesity.

Bariatric surgery (BS) is an effective intervention for severe obesity, but long-term weight regain (WR) can occur and may impact comorbidity outcomes.

Introduction Early-onset obesity increases the risk of developing comorbidities and decreases life expectancy with many variables such as age of onset, severity, and duration of obesity each having an individual influence. Here, we present findings from a model that aims to assess the impact of early-onset obesity. Methods The Early-Onset Obesity Model (EOObesity Model) was built by integrating data from clinical studies with demographic information. It categorizes information into four primary groups: prevalence, morbidity risk, mortality risk, and impact of obesity duration. Type 2 diabetes, cardiovascular events (fatal and non-fatal events, cardiovascular disease, and coronary heart disease), metabolic dysfunction-associated steatotic liver disease, asthma, obstructive sleep apnea, and cancer were evaluated over a range of age and body mass index (BMI) z-scores. Results The EOObesity Model provides a systematic approach for estimating the impact of early-onset obesity on risk of comorbidities and on life expectancy by considering individual patient weight trajectories. We test different scenarios to illustrate the potential impact of age of onset and severity of obesity on the risk of various comorbidities, on life expectancy, and on disability-adjusted life years. The model indicates that severe early-onset obesity has a high impact on life expectancy with, for example, up to 42 years of life lost if a patient has a BMI z-score of 4 by the age of 4 years. Discussion The model and these scenarios underscore the predicted substantially detrimental effects of early-onset and prolonged obesity on life expectancy, and the increased risks of obesity-related comorbidities. They suggest that morbidity and mortality risks increase with obesity duration and severity in a nonlinear manner, thereby supporting the view that early weight loss intervention and obesity prevention strategies may reduce long-term health risks substantially.

Monitoring childhood obesity at a national scale is essential for planning health policies. This study analyzes the two decades secular trends of pediatric weight status in Spain.

The introduction of incretin mimetics (IMs), including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as liraglutide and semaglutide, as well as dual GLP-1/glucose-dependent insulinotropic polypeptide receptor co-agonists (GLP-1/GIP RAs) like tirzepatide, has revolutionized obesity treatment. These obesity management medications promote significant weight loss with metabolic and cardiovascular improvements. However, pharmacotherapy alone seems insufficient to address the multifactorial nature of obesity. While IMs suppress appetite and reduce caloric intake, they do not prevent potential nutrient deficiencies and possible loss of skeletal muscle mass, nor do they guarantee lasting behavioral changes necessary for long-term weight management, particularly in the absence of other complementary interventions.

Despite clinical obesity guidelines recommending evidence-based treatment people with obesity have limited access to these treatments due to restrictions in the healthcare system. At present, little is known how individuals with obesity experience healthcare and what are their opinions on current treatment options.

Given the scarce evidence on mortality risks associated with obesity trajectories beyond body mass index (BMI), this study examined the independent associations of changes in anthropometric and DXA-measured indicators of general and abdominal obesity with all-cause and cardiovascular mortality in older Chinese adults.

Obesity is increasingly prevalent among older adults and is a major contributor to cardiometabolic diseases, functional decline, frailty, and loss of independence. The intersection between population ageing and the obesity epidemic poses major public health and clinical challenges.

Adolescence and early adulthood represent a critical phase for management of chronic diseases, including obesity. To improve transition of care in adolescents and young adults with obesity (AYALwO), the main goal was to summarize the current evidence on transition of care interventions (T-interventions) for obesity management. Anticipating a lack of evidence on T-interventions for AYALwO, we expanded the patient population to include individuals with other chronic diseases that can be appropriately transferred, such as diabetes.

Obesity is a chronic, progressive, and recurring disease that contributes significantly to multimorbidity across Europe. Despite the publication of numerous clinical practice guidelines (CPGs) for obesity, many chronic disease guidelines for obesity related diseases such as diabetes, MASLD, heart disease, obstructive sleep apnea do not integrate contemporary understandings of obesity as an adiposity-based disease requiring direct management in its own right. The objective of this qualitative content analysis was to evaluate the extent to which recent chronic disease CPGs align with current evidence-based obesity guidance.

To improve pediatric obesity treatment, this study aimed to identify predictors of body weight loss (BWL) and its maintenance (BWLM) in children and adolescents.

Genetic forms of obesity, including monogenic (MO) and syndromic (SO) obesity, are characterised by severe, early-onset weight gain due to disrupted central regulation of body weight, typically involving key pathways such as the leptin-melanocortin axis. These alterations result in marked hyperphagia and complex eating behaviours, yet clinical characterisation remains limited. This review aimed to describe the multidimensional eating behaviour profiles across genetically confirmed obesity, explore their variability, and evaluate existing assessment tools to support early diagnosis, personalised care, and therapeutic monitoring.

Obesity increases risk of several diseases and cognitive deficits. Bariatric surgery is the most effective treatment for severe obesity, leading to substantial weight loss and memory improvements. This study examines memory, weight loss, and pathological eating behaviors 5 years postoperatively in a sample of Norwegian bariatric surgery patients.

Body mass index (BMI) is a risk factor for adverse consequences in chronic kidney disease patients. However, its impact on patients undergoing peritoneal dialysis (PD) remains uncertain. We conducted a comprehensive systematic review and meta-analysis to assess the impact of baseline BMI on PD outcomes.

Metabolic and bariatric surgery (MBS) leads to substantial muscle mass loss. Resistance training (RT) is an effective strategy to maintain muscle mass. This study aimed to gain insight into the motivators, barriers, and preferences that are correlated with RT uptake after MBS.

The association of hunger and weight status or weight change is unclear. We aimed to assess the cross-sectional and prospective associations between hunger levels and weight status and change.

This study assesses explicit weight bias (EWB) among French medical students and its association with demographic factors and educational tools.

Sleeve gastrectomy (SG) and one anastomosis gastric bypass (OAGB) are two of the three most performed metabolic and bariatric surgery (MBS) procedures worldwide. Indication for the proper surgical procedure is based on the surgeon's choice, and no validated score for procedure selection exists. The aim of this study was to develop and validate a clinical score, which standardizes procedure selection in MBS.