Epithelium is the periodontal first line of defense against microbes. Discoidin domain receptor 1 (DDR1) is a collagen receptor expressed in epithelium. Ddr1 knockout (Ddr1) mice develop periodontitis-like defects, including junctional epithelium (JE) downgrowth, bacterial invasion, and alveolar bone loss. The objective of this study was to investigate epithelial responses in the absence of DDR1. We hypothesized that Ddr1 mice exhibit increased JE permeability and delayed epithelial wound healing.

A randomized, controlled trial was conducted to evaluate the effectiveness of two supportive periodontal care (SPC) approaches in patients with periodontitis and to evaluate possible predictors influencing bleeding on probing (BoP) changes at 24-month follow-up.

Patients with periodontitis can exhibit persistent periodontal pockets with bleeding representative of inflammation. This clinical study aimed to evaluate the effectiveness of a chitosan brush in improving residual periodontal pockets in patients who had already undergone causative therapy for periodontitis.

This study investigated the association of inflammatory markers in saliva, plasma, and cerebrospinal fluid (CSF) with cognitive decline and periodontitis.

The potential of hydrogen sulfide (HS) gas as a biomarker for periodontitis has been suggested, but the evidence remains inconclusive. This preliminary study aimed to explore the relationship between periodontitis, defined according to the 2018 classification by the American Academy of Periodontology and the European Federation of Periodontology and exhaled HS gas in the Thai population.

Periodontitis requires long-term management to prevent recurrence and tooth loss. While active periodontal therapy (APT) aims to reduce probing pocket depth (PPD) and improve clinical attachment level (CAL), strict supportive periodontal care (SPC) is essential for maintaining these clinical outcomes. This study systematically reviewed the long-term benefits of APT interventions (test groups) compared to standard control interventions (control groups) in patients undergoing SPC as part of randomized controlled trials (RCTs).

Periodontitis (PD) occurring during orthodontic treatment may interfere with the bone remodeling process. This study investigated the impact of PD on bone remodeling during orthodontic tooth movement (OTM) and explored the potential role of C-reactive protein (CRP) and the IL-6/JAK2/STAT3 signaling pathway in this process.

Numerous studies have reported an association between depression and periodontitis, though results are inconsistent and highly heterogeneous. The present study aimed to examine the potential confounding role of poor socioeconomic status (SES) in the association between depression and periodontitis by performing a secondary analysis of the National Health and Nutrition Examination Survey (NHANES) data.

The identification of molecular biomarkers that help clinicians in early diagnosis is a key focus of periodontal research. The major aim of this cross-sectional observational study was to assess whether salivary TAM pathway protein levels have the potential to discriminate between periodontally healthy or gingivitis controls and periodontitis patients, including those with mild (I/II) or severe (III/IV) disease.

Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this field. The objective of this study was to describe the study design characteristics of RCTs that have evaluated the effect of non-surgical periodontal treatment on systemic health outcomes.

The association between periodontitis (PD) and rheumatoid arthritis (RA) has been linked to autoantibodies. In recent years, Arg-gingipain (Rgp) triggered myeloperoxidase (MPO) release, which mediates protein carbamylation to form anti-carbamylated proteins (anti-CarP), perpetuating RA progression has gained interest. This study assessed the association between Rgp with MPO and anti-CarP in pre-clinical RA (preRA), early RA (eRA), and established RA (RA) participants with PD.

Accumulation of senescent cells is increasingly recognized as a mechanism of aging and is considered an attractive therapeutic target for various age-associated diseases. The prevalence and severity of periodontitis increase with age, and preclinical studies have demonstrated that senescent cells could be a potential therapeutic target for age-associated periodontitis. However, clinical data linking cellular senescence and periodontitis are limited.

This study investigates how poor oral health impacts metabolic alterations, specifically evaluating the effects of periodontitis and tooth loss, either individually or in combination, on the number of metabolic syndrome (MetS) indicators.

This study aimed to investigate the association between periodontitis severity and the risk of gestational diabetes mellitus (GDM) considering pathways induced by systemic inflammation.

A self-reported questionnaire developed by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) has demonstrated adequate reliability for evaluating periodontal status in national surveillance surveys--which has been translated and validated in multiple languages--but has not yet been tested in Thai. Therefore, this cross-sectional study evaluated the validity of the CDC/AAP self‑report questionnaire for periodontitis in a Thai population.

Periodontitis and major depression disorder have been shown to have a bidirectional association. However, the impact of antidepressants, the primary pharmacological treatment for depression, on periodontal health remains unclear. Given their anti-inflammatory properties, antidepressants may exert a protective effect against periodontitis. This study aimed to investigate the association between antidepressant use and the prevalence of periodontitis in a large, nationally representative sample of the United States (US) population.

Direct comparative data on periodontal regeneration (PR) versus extraction and implant placement remain limited. Tooth-specific periodontal conditions such as furcation involvement and overall tooth prognosis may dictate success or failure of such treatment.

Emerging evidence indicates that oral health and metabolic dysfunction-associated steatotic liver disease (MASLD) may be interconnected through shared genetic and metabolic pathways. However, the specific mechanisms underlying this association remains poorly understood.

Although periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease measures for CMD mortality in the National Health and Nutrition Examination Survey (NHANES).

Hypoxia modulates inflammation and oxidative stress through hypoxia-inducible factor-1α (HIF-1α). Ferroptosis, an iron-dependent cell death process, is regulated by glutathione peroxidase-4 (GPX4) and involves lipid peroxidation markers like malondialdehyde (MDA). This study evaluates HIF-1α, GPX4, and MDA levels in peri-implant crevicular fluid (PICF) across peri-implant health, mucositis, and peri-implantitis.

There is demand for new biomaterials that reduce the morbidity associated with a second graft site needed for autologous bone grafting and facilitate the surgical procedure. Here we compared bone volume gain using a supercritical CO-processed allogeneic bone paste and bone powder in partially edentulous patients requiring bone augmentation of alveolar ridges by guided bone regeneration (GBR) to place one or more implants.