Obesity is linked to gut microbiota dysbiosis, and diet is a key determinant influencing the gut microbiome. This study examined the association between a newly proposed Dietary Index for Gut Microbiota (DI-GM) and obesity in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020.

Hyperglycemic individuals, who are prone to microvascular complications of diabetes (MCDs) like diabetic patients, may benefit from timely carbohydrate intake intervention. But there remain inconsistent results and lack of focus on carbohydrate subtypes, which may have distinct effects. This study aimed to investigate the associations between dietary carbohydrate subtypes and the MCDs incidence in hyperglycemic individuals.

Although nutritional supplementation and exercise have shown independent efficacy in managing sarcopenia, data supporting their combined implementation in real-world clinical settings remain limited.

Multimorbidity has posed growing global health burdens, yet evidence on modifiable dietary risk factors remains limited. To explore the dietary factors influencing multimorbidity risk, a longitudinal study was conducted in the UK Women's Cohort.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women. This study investigates the impact of 8-week supplementation with two probiotic strains, Lactobacillus helveticus and Bifidobacterium longum, on hormonal status, oxidative stress, and clinical symptoms in women with PCOS. Conducted as a double-blind, placebo-controlled, randomized clinical trial, the research involved 90 women with PCOS from Shahid Beheshti Hospital, Isfahan, Iran. Serum markers were assessed before and after the intervention. After adjusting for baseline values and confounding variables, the 8-week supplementation with two probiotic strains resulted in a significant increase in sex hormone binding globulin (24.39; 95% CI (15.23,33.55) vs. -11.99; 95% CI (-20.12, -3.86) nmol/L, P < 0.001), total antioxidant capacity (125.53; 95% CI (53.78,197.28) vs. -42.90; 95% CI (-78.32, -7.48) nmol/mL, P = 0.002) and Superoxide dismutase activity (0.19; 95% CI (0.09,0.30) vs. -0.11; 95% CI (-0.18, -0.04) U/mL, P < 0.001), in the intervention group compared to the placebo. While free androgen index (-57.05; 95% CI (-80.33, -33.76) vs. 49.86; 95% CI (28.81,70.92), P < 0.001), C-reactive protein (-0.50; 95% CI (-0.95, -0.04) vs. 0.05; 95% CI (-0.39,0.50), P = 0.046), and malondialdehyde levels (- 23.69; 95% CI (-30.02, -17.35) vs. -2.70; 95% CI (-9.19,3.77), P < 0.001), significantly decreased in the intervention group compared to the placebo. Furthermore, testosterone total levels showed a decreasing trend in the intervention group, although the between-group changes were not statistically significant after baseline value and other confounders adjustment (-3.37; 95% CI (-11.85, 5.11) vs. 6.48; 95% CI (3.43, 9.53) ng/dL, P = 0.08). Regarding clinical symptoms, including acne, alopecia, and hirsutism, the between-group changes were insignificant (P > 0.05). In conclusion, these findings suggest that 8 weeks of probiotic supplementation may alleviate oxidative stress, modulate certain hormonal factors, and reduce inflammation in women with PCOS. Trial registration, the current study was registered in the Iranian Registry of Clinical Trials on 30 March 2024 (ID: IRCT20121216011763N62) ( https://irct.behdasht.gov.ir/trial/76067 ). https://irct.behdasht.gov.ir/trial/76067 .

This study examined the associations of phenotypic age (PhenoAge) acceleration and dietary fiber intake with mortality risk among middle-aged and older adult cancer survivors.

Esophageal squamous cell carcinoma (ESCC) is commonly associated with high rates of malnutrition, adversely affecting patient outcomes. This study aims to assess the impact of nutritional support combined with concurrent chemoradiotherapy (CCRT) on survival and prognosis in ESCC patients, utilizing prognostic models based on five key immunonutritional indicators.

The quest towards more feasible, low-cost yet accurate dietary assessment methods has led to the development of the new Experience Sampling-based Dietary Assessment Method (ESDAM). ESDAM is an app-based quantitative dietary assessment method to assess habitual dietary intake over a period of 2 weeks. ESDAM prompts three 2-hour recalls daily requesting to provide dietary intake on meal and food group level. The ESDAM allows to measure dietary intake near real-time in a rapid, low-cost and feasible manner. Following the user experience evaluation of the ESDAM, the validity of the ESDAM will now be assessed against objective biomarkers.

Hyperuricemia is increasingly acknowledged as a major public health issue. Current evidence on the effects of urinary phytoestrogen biomarkers on hyperuricemia is limited. Moreover, the potential mediation effect of kidney function was not assessed.

Concerning rare evidence on the relationship of dietary nitrate (NO)/nitrite (NO) from plant or animal food groups with metabolic syndrome (MetS) in children and adolescents, this study investigates the longitudinal association of total, plant- or animal-sourced dietary NO/NO intake in children and adolescents with the incidence of MetS and its risk factors.

Immune-inflammatory deregulation in depression may contribute to elevated risk of subsequent mortality. While dietary omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), are known to confer neuroprotective effects for their anti-inflammatory properties, population-based evidence regarding their survival benefits and underlying mechanisms in depression remain scarce. This study aimed to investigate association between dietary omega-3 PUFAs and mortality risk in depressed individuals and identify immune-inflammatory mediation underlying mortality reductions.

Chronic obstructive pulmonary disease (COPD) is a leading cause of death and is closely linked to cardiovascular disease (CVD) and metabolic disorders. The triglyceride-glucose (TyG) index and related indices are potential markers for all-cause and CVD mortality. This study aimed to evaluate their predictive value in patients with COPD.

Supplementation of the diet with phosphatidylserine (PS) is associated with cognitive and neuropsychological benefits in healthy and neuro-compromised adults. It has also been shown to mitigate symptoms of inattention in children with attention-deficit hyperactivity disorder. However, there is little data on the effects of PS in healthy children.

This study aims to explore the association of BRI with all-cause, cardiovascular disease (CVD)-cause, and cancer-cause mortality risk, and the role of biological age acceleration (BAA) in mediating these associations.

The increasing intake of sugar-sweetened (SSBs) and artificially sweetened beverages (ASBs) raises concerns over their potential impact on cardiovascular health. This umbrella meta-analysis examines their association with cardiovascular outcomes, synthesizing existing evidence comprehensively.

Muscle loss is linked to multiple adverse outcomes, but its impact on rheumatoid arthritis (RA) prognosis is unclear. This study aimed to examine the association between muscle mass and mortality in RA patients.

Circadian Syndrome (CircS) expands on metabolic syndrome (MetS) by including circadian rhythm disturbances and depression. It has been shown to be a better predictor of cardiovascular disease (CVD) than MetS. While magnesium has been linked to circadian rhythm disturbances, its association with CircS remains unclear. This study aimed to investigate the association between dietary magnesium intake and CircS using data from the National Health and Nutrition Examination Survey (NHANES).

Kiwifruit is widely recognized for its nutritional value and health benefits, yet reliable and objective methods for assessing kiwifruit intake in populations remain limited.

Serving as the predominant energy substrate, dietary carbohydrate consumption patterns significantly influence human health. However, the association between carbohydrate intake and asthma risk remains unclear. This study aims to systematically review and meta-analyze existing evidence on associations between various carbohydrate types (including free sugars [FS], non-free sugars [NFS], refined grains [RG], whole grains [WG], and dietary fiber [DF]) and risk of asthma.