Diabetes mellitus (DM) significantly increases the risk of atrial fibrillation (AF), yet the underlying mechanisms remain poorly defined. Arachidonic acid (AA), a key omega-6 fatty acid involved in redox and inflammatory regulation, has been implicated in cardiovascular homeostasis, but its role in diabetes-related atrial remodeling and AF susceptibility is unclear.

Cancer remains one of the most formidable diseases affecting human health, particularly because it involves complex reprogramming of metabolic pathways, especially pathways involved in lipid metabolism. Ether lipids (ELs), which alter membrane fluidity and signaling pathways that promote tumor initiation and development, have emerged as important regulators of cancer biology, positioning them as emerging candidate targets for diagnosis and treatment. The main focus of this review is the metabolic dysregulation of ELs in tumors, particularly the metabolic, genetic, and epigenetic processes that promote invasion, proliferation, and drug resistance. This review highlights preclinical treatment strategies designed to target EL synthases, aiming to provide novel perspectives for future translational applications that support more sustainable therapeutic options. In addition to future prospects centered on standardized detection and multiomics integration to improve precision oncology, important hurdles, including tissue specificity and metabolic heterogeneity, are covered.

Industrialized eating habits have disrupted the balance between n-6 to n-3 polyunsaturated fatty acids, a change reflected in human tissue composition. Increased n-6 to n-3 ratios may contribute to the emergence of several neurodevelopmental conditions. This study aims to determine how the balance between dietary n-6 and n-3 fatty acids relates to attention-deficit/hyperactivity disorder (ADHD) in kids and teenagers in the U.S.

Chronic Obstructive Pulmonary Disease (COPD), defined by persistent airflow obstruction, is increasingly understood as a systemic inflammatory disorder. This condition is also frequently accompanied by profound metabolic dysregulation. The ratios comparing certain immune cell populations to High-density lipoprotein cholesterol (HDL-C) values are gaining attention as potential markers of inflammation in multiple chronic illnesses. However, the relationship connecting inflammatory indices related to HDL-C with the frequency of COPD occurrence is not yet well-established.

Visceral (VAT), subcutaneous (SFT), and total body fat (FM) contribute to hepatic steatosis, yet their relative and sex-specific effects across total, regional, and site-specific levels remain unclear. We investigated associations between fat depots, standardized skinfold sites, and liver fat (LF) while adjusting for key metabolic covariates.

Maintaining a proper balance between saturated and unsaturated fatty acids in membrane phospholipids is essential for normal cellular function. The evolutionarily conserved transmembrane protein AdipoR2 plays a central role in this homeostatic process. While the detrimental effects of saturated fatty acids on cells have been previously documented, the associated ultrastructural changes remain less investigated.

Sun sensitivity, an abnormal skin reaction to ultraviolet radiation, increases the risk of melanoma and impairs the quality of life. In recent times, the body roundness index (BRI) has been suggested to be associated with various health conditions. Nevertheless, the association between the BRI and sun sensitivity remains not well understood. The purpose of this research was to investigate the association between the BRI and sun sensitivity.

Prior studies on the relationship between high-density lipoprotein cholesterol (HDL-C) and depression have reported inconsistent results. Insulin resistance (IR) can alter the composition and function of HDL. This study aims to investigate whether IR influences the association between HDL-C and depression.

Lipid-derived composite indices demonstrate robust epidemiological associations with diverse metabolic and cardiovascular disorders due to their integrative nature; however, their relationship with hyperuricemia (HUA) in older adults remains unexplored. This research examines the links between six blood lipid indices and HUA in older Chinese adults and assesses their diagnostic accuracy for HUA association stratification.

Atherosclerosis (AS) is a complex cardiovascular disease characterized by dysregulated macrophage cholesterol metabolism (CM), a central driver of foam cell formation and plaque progression. However, how macrophage CM becomes dysregulated is still not fully understood. Single-cell RNA sequencing (scRNA-seq) was combined with bulk RNA-seq data to identify CM-related genes with diagnostic and therapeutic potential.

Early identification of high-risk individuals after Acute Coronary Syndrome (ACS) is critical for tailoring intensive lipid-lowering therapy, a cornerstone of secondary prevention to alleviate the growing global burden of cardiovascular diseases, while practical tools integrating lipid burden and vascular aging remain lacking. This study proposes the age-multiplied low density lipoprotein cholesterol (LDL-C) burden (AM-LDL) index to quantify cumulative atherogenic exposure and stratify 1-year ischemic and bleeding risk.

To characterize the specific pattern of body fat distribution and its association with metabolic syndrome (MetS) among Tibetan adults, an understudied population with distinct high-altitude adaptations, and to identify potential mediating biomarkers in serum lipoprotein profiles.

Lipid metabolism may be linked to chronic gastritis, but its causal role remains unclear. While current research emphasizes inflammation, mucosal changes, immune regulation, genetics, and the gut microbiota, the contribution of lipid metabolism is understudied. This study aims to evaluate the impact of serum lipids and the mechanistic roles of lipid-lowering drug targets in chronic gastritis.

Insulin resistance (IR), as measured by the triglyceride glucose index (TyG-i), and whole body fat, assessed through relative fat mass (RFM), are significant risk factors for cardiovascular disease (CVD). However, the combined impact of these two parameters on the incidence of new-onset CVD events remains underexplored. This cohort study aims to investigate the individual, synergistic, and potential interactive effects of RFM and TyG-i on the risk of developing new-onset CVD.

An osteoporotic fragility fracture occurs every three seconds, with a particularly high incidence after the age of 65, reflecting a substantial decline in bone mass. Given the limitations of dual-energy x-ray absorptiometry (DXA) in early-stage bone mineral density (BMD) assessment, we aim to employ ultrasound-based BMD evaluation within community populations to gain a deeper understanding of the age at which bone mass reduction begins and the associated risk factors.

The Zhejiang University (ZJU) Index, a composite metabolic indicator incorporating body mass index (BMI), fasting plasma glucose (FPG), triglycerides (TG), and alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio, is associated with abnormalities like dyslipidemia and glucose intolerance. Yet its clinical significance in cardiovascular disease (CVD) is underinvestigated, and this study aims to clarify its associations with prevalent CVD, all-cause mortality, and CVD mortality.