Survivors of critical illness frequently experience long-term impairments. Chronic critical illness (CCI) affects patients requiring prolonged ICU treatment and mechanical ventilation and is often complicated by critical illness polyneuropathy/myopathy (CIP/CIM). However, long-term data on CCI and CIP/CIM-particularly regarding activities of daily living (ADL), physical activity, and care situation-are limited.

Improving early recognition and treatment of sepsis is key to decreasing patient mortality. The current study investigates barriers and facilitators to timely and appropriate sepsis care from the perspectives of care team members across different roles at a large academic health system.

Positive pressure ventilation (PPV) alters hemodynamics and neurohormonal regulation, leading to sodium and water retention. Transition to unassisted breathing is expected to reverse these effects, but the magnitude and clinical relevance of this have not been fully characterized.

Large language models (LLMs) are capable of processing extensive textual data and synthesizing evidence to answer complex clinical questions. The labor-intensive nature of systematic reviews with meta-analyses (SRMAs) present a unique opportunity to evaluate the utility of LLMs as a novel method for evidence synthesis.

Sepsis is a very severe condition that carries a high risk of death. Blood purification methods have been employed alongside conventional treatment to help decrease the death rate associated with severe sepsis.

Aneurysmal subarachnoid hemorrhage (aSAH) is an heterogeneous disease with variable outcomes, even among patients with similar clinical and radiological severity. Additional research is needed to better stratify aSAH patients.

Whether outcomes related to mechanical ventilation differ between men and women remains unclear. This study aims to investigate whether respiratory variables and regional lung mechanics in critically ill mechanically ventilated patients differ between men and women, and if so, whether anthropometric parameters could explain the difference.

Multidrug-resistant Gram-negative bacteria (MDR-GNB) are increasingly encountered in intensive care units (ICUs), where prolonged antibiotic courses are often prescribed despite limited evidence guiding optimal duration. Determining whether shorter regimens are as effective as extended therapy is essential for stewardship and patient outcomes. We performed an aggregate data meta-analysis pooling two randomized controlled trials (RCTs): OPTIMISE (7 vs. 14 days) and REGARD-VAP (individualized 6-7 vs. 8-9 days) in MDR-GNB infections. The primary outcomes were composite outcome of mortality and reinfection/recurrence, mortality, and reinfection/recurrence. Random- effects models generated pooled odds ratios (OR) with 95 % confidence intervals (CI). Across 602 ICU patients, Klebsiella pneumoniae was the most frequent resistant pathogen, with Pseudomonas aeruginosa more prominent in OPTIMISE and Acinetobacter baumannii in REGARD-VAP. Short-course therapy did not significantly differ from extended therapy for mortality (OR 0.74, 95 % CI 0.45-1.23, I = 18 %) or clinical failure (OR 0.82, 95 % CI 0.50-1.36, I = 0 %). Relapse occurred more often with short-course therapy (OR 2.04, 95 % CI 0.85-4.92, I = 22 %) but was not statistically significant. Shorter regimens appear comparable to extended courses in critically ill patients, though potential relapse risk warrants further study. Future individual patient data meta-analyses may clarify pathogen- and host-specific factors guiding optimal duration.

To test the feasibility of a novel approach for eliciting personhood in ICUs.

Critical illness is associated with hypercatabolism, systemic inflammatory dysregulation and low serum concentration of testosterone (T) leading to intensive care unit (ICU) acquired weakness and altered outcome. T supplementation benefit has been reported in several illnesses but data in non-burned ICU patients are scarce. In this context, the purpose of the TestICUs-1 study was to assess the pharmacokinetic and safety of T-gel administration in ICU patients.

Severe hypernatremia (serum sodium (SNa) ≥ 155 mmol/L) in critical illness is associated with high mortality; however, the optimal correction rate remains uncertain. We compared outcomes of fast (>0.5 mmol/L/h) versus slow (≤0.5 mmol/L/h) SNa correction within the first 24 h.

Vasopressors are frequently administered in the emergency department (ED) to improve hemodynamic stability in critically ill patients. Due to their potent vasoconstrictive properties, these medications are typically delivered through a central venous catheter (CVC) to minimize the risk of extravasation or infiltration. The use of peripheral venous access for administering vasopressors has grown as more safety data has been published; however, the majority of data does not include vasopressin.

The Association between hyperoxia and mortality in patients receiving extracorporeal membrane oxygenation (ECMO) remains controversial. This study aimed to systematically evaluate the impact of arterial hyperoxia on mortality in adult ECMO patients.

Diversity in intensive care medicine (ICM) contributes to equity, team performance, and innovation. However, international data highlight persistent gender disparities in leadership, authorship, and specialty composition. While Türkiye appears to have balanced gender representation in critical care, a national analysis has been lacking.

Trauma-related acute kidney injury (AKI) is associated with increased mortality. Anemia on admission has been reported as a risk factor for AKI in non-trauma patients. Several studies have reported an association between anemia and trauma-related AKI. However, very few studies specifically focused on the association between anemia at emergency department (ED) admission and trauma-related severe AKI. We aimed to investigate this association in this post-hoc analysis.