This study investigated the role of copper metabolism MURR1 domain-containing 1 (COMMD1) in Talaromyces marneffei (TM)-induced osteomyelitis (OM) and its regulation of osteoclast differentiation via the NF-κB pathway.

() had been reported as a rare cause of human infections. In this study, we isolated an uncommon strain of from swab specimens of a male patient with cerebral infarction. The identification was performed using VITEK MS in the RUO (Research Use Only) mode and 16s rRNA gene sequencing. We hereby report a case of chronic osteomyelitis caused by in a patient with cerebral infarction and left-sided limb hemiplegia in China.

To analyze and discuss the clinical characteristics of carbapenem-induced platelet abnormalities.

Antimicrobial resistance (AMR) is the number one cause of death globally, and Sub-Saharan Africa bears the most significant burden. Previous studies conducted in Uganda have revealed high rates of antimicrobial prescribing in hospitals, with evidence of widespread inappropriate use, which necessitates the development of targeted interventions. The inappropriate use of antimicrobials is a driver of AMR. We conducted point-prevalence surveys of antimicrobial prescribing in selected health facilities in central Uganda to identify areas for improvement.

Infective endocarditis (IE) is a severe infectious disease affecting the endocardium and cardiac valves, caused by various pathogens. Among numerous pathogenic microorganisms, is the most common, followed by other streptococci such as and enterococci. , a Gram-negative, fastidious parasitic bacillus, is a rare causative agent of IE , belonging to the group, commonly colonizes oral cavity, upper respiratory tract, and gastrointestinal tract, which can cause infections when host immunity is impaired. This study demonstrates a surviving case of infective endocarditis caused by , initially illustrating cardiac arrest and infection.

is a thermally dimorphic fungus traditionally associated with HIV-related immunosuppression. However, increasing reports have described infections in HIV-negative patients with hematologic malignancies, particularly those receiving novel immunosuppressive therapies.

Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) pose a significant public health threat. While carbapenems are known to be superior in treating bacteremic infections, the evidence is unclear for non-bacteremic infections.

Antimicrobial resistance (AMR) is a major global health threat, primarily driven by inappropriate antibiotic use. This cross-sectional study assessed the knowledge, attitudes, and practices of healthcare professionals in Saudi Arabia regarding antimicrobial use, resistance, and stewardship to identify gaps contributing to misuse.

This study evaluated the prevalence of in cystic fibrosis(CF) patients, assessed its resistance patterns to commonly used antibiotics with an emphasis on fosfomycin, and examined the presence of resistance genes () in these isolates.

(KP), a clinically significant Gram-negative opportunistic pathogen, has emerged as one of the predominant causative agents of hospital-acquired infections (HAIs). This bacterium is responsible for various severe clinical manifestations, including pneumonia, urinary tract infections, bloodstream infections, and sepsis. In recent years, the global prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has been escalating rapidly. Epidemiological surveillance data reveal a persistent upward trend in infections caused by MDR microorganisms worldwide, a phenomenon disproportionately prevalent in resource-limited developing countries. This trend presents formidable challenges to clinical infection management and constitutes a critical threat to global public health security. In the context of bacterial antibiotic resistance, the phenomenon of heteroresistance (HR) has attracted growing scientific attention due to its unique clinical significance. HR is characterized by the coexistence of subpopulations within a clonal (ie, genetically similar) bacterial population that exhibit divergent susceptibility profiles to an antimicrobial agent. This subtle phenotypic heterogeneity is considered a crucial precursor to the development of stable, high-level antibiotic resistance, representing a pivotal transitional phase in the evolution of MDR. The clinical importance of HR is twofold: first, the resistant subpopulations are often missed by conventional antimicrobial susceptibility testing, potentially leading to unexpected treatment failure. Second, HR serves as an early warning indicator for the impending emergence of complete resistance.

Bloodstream infections (BSIs) caused by carbapenem-resistant (CRKP) pose a huge threat to global public health. The mortality rates are particularly high among older adults. However, few studies have focused on CRKP BSIs in older adults. This study aims to investigate the clinical and genomic characteristics of CRKP-BSIs in older adults.

(), traditionally regarded as a nosocomial pathogen, has emerged as an increasingly recognized etiologic agent in community-acquired pneumonia (CAP). Cavitary lung lesions-a severe complication of CAP characterized by parenchymal necrosis and cavity formation-are exceptionally rare in associated CAP. We report a 64-year-old male with CAP complicated by infection (positive genotype carrying the virulence factors and ), which rapidly progressed to cavitary lesions in the right upper lobe. This case highlights the aggressive clinical trajectory and antimicrobial resistance challenges inherent to community-acquired infections. Furthermore, it underscores the imperative for serial radiographic monitoring to detect cavitary evolution and the critical role of comprehensive antimicrobial susceptibility testing in guiding precision therapy.

A novel bacterial strain, designated as L3024hy, was isolated from the fecal matter of a patient suffering from diarrhea in China. Whole-genome sequencing has identified this strain as a member of the genus . Comparative genomic analyses, including Average Nucleotide Identity (ANI) and digital DNA-DNA hybridization (dDDH), indicated that L3024hy constitutes a distinct lineage within this genus, as evidenced by ANI and dDDH values falling below established thresholds for species demarcation. This strain harbors multiple virulence genes associated with host colonization, suggesting its potential clinical significance. This study underscores the increasing diversity of the genus and emphasizes the necessity for further research on its role in human infections.

Infections at surgical sites are a significant risk to patients undergoing surgery, increasing hospitalization and health care costs, morbidity, and mortality. Participation of patients in healthcare decision-making helps identify community needs and preferences, resulting in more patient-centered and effective care. To achieve positive surgical outcomes, patients must cooperate and participate in preoperative and postoperative care, including postoperative wound care.

The increasing utilization of antiretroviral (ART) medications by people living with HIV(PLWH) poses a potential risk to the efficacy of standardized ART management protocols in resource-limited settings, particularly as it may accelerate the emergence of transmitted drug resistance (TDR). Our research aimed to elucidate the prevalence, risk factors, geographical variations, and transmission patterns of TDR to inform and enhance ART management strategies.

Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy and a high mortality rate if untreated. While TTP can be primary or secondary to factors like drugs, reports linking it to anti-tuberculosis (anti-TB) therapy are scarce. This case highlights the diagnostic challenges and need for vigilance in TB patients receiving standard regimens.

The mpox virus (MPXV) is a zoonotic pathogen that has been causing a worldwide pandemic outbreak since 2022, posing a significant threat to global public health security. During this outbreak, monkeypox has been more prevalent among immunocompromised individuals, particularly those infected with HIV (Human Immunodeficiency Virus). We report a case of a 21-year-old male patient with advanced AIDS in China who developed severe complications, including skin tissue infection, proctitis, and conjunctivitis, following monkeypox infection. Despite early aggressive treatment, the patient ultimately succumbed to infectious shock and multiple organ failure. This case strongly underscores that such patients experience severe skin infections and rapid disease progression, necessitating urgent early recognition and treatment.

To analyze the risk factors for 30-day prognosis in patients with hemorrhagic fever with renal syndrome (HFRS) in the Dali region of China, and to provide a theoretical basis for the diagnosis and treatment of HFRS.

subsp. is an emerging member of the complex that is often misidentified in routine diagnostics. Its clinical relevance and genomic characteristics remain poorly understood.

This study leveraged CSF metagenomic next-generation sequencing (mNGS) to bridge this knowledge gap and elucidate the microbiota spectrum of CNS infections.

Q fever is a globally distributed zoonotic disease caused by (). As an obligate intracellular bacterium, is primarily transmitted from domestic animals to humans, with ticks also serving as potential vectors. The clinical manifestations of Q fever are often nonspecific and highly variable, making its diagnosis particularly challenging.