We are pleased to present the accepted abstracts from the 13th Annual Symposium on Global Cancer Research (ASGCR). The 2025 symposium highlights both the commitment and growth of the global oncology community, marking 5 years since ASGCR's transition to a fully virtual format. What began as a pandemic-driven necessity has evolved into a deliberate strategy to broaden participation and minimize barriers. Over this period, ASGCR has expanded its reach, expanded its content, and strengthened global collaboration through initiatives such as requiring low- and middle-income country coauthorship, launching the Early Career Investigator Day, and adopting open calls for scientific session proposals.

Oral cavity cancer (OCC) is marked by racial and ethnic disparities. We examined these differences in OCC stage at diagnosis and whether neighborhood-level social vulnerability, a measure of susceptibility to hardship at the census-tract level, modifies disparities.

Cancer patients with sepsis experience a higher mortality risk than non-cancer patients. However, it remains unclear how this risk varies with cancer type and metastasis status, sex, age, and infecting microbe.

Mammographic parenchymal texture is a predictor of breast cancer risk, but knowledge of the clinical or epidemiologic factors that contribute to texture variability is limited. We evaluated the relationship between texture and breast cancer risk factors among women participating in mammography.

Treatment approaches differ for isolated in-breast tumor recurrence (representing treatment failure) and new primary breast tumors (representing high etiologic risk). However, methods for distinguishing recurrences from second primaries (based on radiographic and histologic criteria) are subject to error. Gold standard genomic datasets for assessing classification accuracy have been lacking.

Cancer survivors have a higher risk of job loss than individuals in the general population. We aimed to investigate the employment status of cancer survivors in Japan.

The purpose of this study was to estimate the prevalence of rare cancer survivors in the United States (US).

The safety of using acetaminophen (paracetamol) during pregnancy has been questioned due to concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to investigate whether maternal prescriptions of acetaminophen during pregnancy are associated with childhood cancer.

Healthy dietary patterns have been linked to reduced cancer risk, but evidence for prostate cancer (PCa) remains inconsistent, especially across diverse populations.

C-reactive protein (CRP) is a widely used inflammatory biomarker that has been related to colorectal cancer (CRC) risk. However, observational studies are prone to confounding and reverse causality.

Emerging evidence indicates that lipid metabolism plays a crucial role in gastrointestinal (GI) cancers.

The global incidence of kidney cancer has significantly increased among individuals under 50 years of age. However, genetic predisposition alone does not account for this trend. This study investigated the association between nonalcoholic fatty liver disease (NAFLD) and the risk of early-onset kidney cancer.

Engaging men may contribute to cervical cancer prevention; however, little is known about what factors may be associated with men's engagement in cervical cancer prevention and therefore where interventions should focus.

Alcohol, a known carcinogen since 1988, increases risk of cancers of the mouth, pharynx, larynx, esophagus, liver, breast, and colorectum. Over one-half of U.S. adults consume alcohol while about two-thirds are unsure if or unaware that alcohol intake is linked to cancer risk.

Geodemographic segmentation (GDS) is a business-based methodology that groups customers into "segments" based on similarities and designs directed marketing campaigns. GDS is an underutilized resource in medicine but holds much potential to encourage patients to follow evidence-based guidelines.

As the number of cancer survivors in the U.S. grows, multiple primary cancer (MPC) has become an increasing public health concern. Understanding geographic variation in MPC incidence can inform targeted public health strategies. In this study, we aimed to examine associations between MPC incidence and county-level smoking prevalence.

Research has linked neighborhood factors (e.g., air pollution, obesogenic environment) often associated with residential segregation to cancer disparities, including mortality. Limited research has explored these multilevel drivers of health, recognizing residential segregation as upstream of neighborhood social, built, and physical environment attributes. In this study we describe the neighborhood data resource of the Pathways Study, a diverse cohort of women diagnosed with breast cancer.

Iron is one of the essential elements for human life. Prior studies provided inconclusive results regarding the association between dietary iron intake and gastric cancer risk. We determined the association between dietary iron intake and risk of gastric cancer in a case-control study of 1,182 incident gastric cancer cases and 2,965 controls in Vietnam.

Individuals undergoing lung cancer screening (LCS) have high comorbidity burden, yet the extent and impact of frailty are unknown. We sought to characterize the predicted probability of frailty and comorbidity burden among individuals undergoing LCS and compare screening results and downstream healthcare utilization in those with less versus more frailty and comorbidity.

Atrial fibrillation (AF) and ovarian cancer (OCA) are leading causes of morbidity, with emerging evidence suggesting potential interplay. However, their temporal and genetic relationships remain unclear.

Alcohol use increases the risk of seven cancers, including breast and colorectal cancers. Awareness of this is low in the US population (34%), which impedes risk reduction efforts, support for alcohol regulation policies, and physician and family communication about this topic. Efforts to improve awareness of the cancer risks of alcohol will require multiple approaches including the use of educational messages tailored to audience needs. There is a lack of evidence regarding how existing messaging influences awareness, and characteristics associated with awareness that could guide future messaging.