Cervical cancer is the fourth most common cancer worldwide among women. Surgical staging by para-aortic lymph node dissection (PALND) is performed when the cancer is locally advanced (LACC). There are no recommendations concerning the number of lymph node that must be removed during this surgery which hasn't prove is effectiveness concerning survival.

The clinical importance of treatment approaches based on genomic sequencing has increased in esophageal cancer. This study aimed to clarify the current status and clinical usefulness of genomic panel testing using PleSSision-160 for resectable esophageal squamous cell carcinoma (ESCC).

Neoadjuvant pembrolizumab combined with chemotherapy is now standard treatment for stage II and III triple-negative breast cancer (TNBC). However, its impact on postoperative complications remains underexplored especially in oncoplastic or reconstructive procedures.

The da Vinci SP robotic platform offers a novel single-port approach for minimally invasive surgery. Despite its potential, data on its safety and performance in gynecologic oncology remain limited. We aimed to compare surgical outcomes of da Vinci SP versus da Vinci Xi systems in the staging of endometrial cancer (EC).

Cancer surgery accounts for a substantial proportion of allogeneic blood use. As demographic changes lead to a growing number of oncologic procedures, transfusion demands are increasing, while blood supply shortages persist. Moreover, allogeneic blood transfusions carry inherent risks, especially in cancer patients, due to potential transfusion-associated immunomodulatory effects. Intraoperative cell salvage (IOCS) potentially presents a promising strategy to reduce allogeneic transfusions. However, its application in oncologic surgery remains controversial due to the theoretical risk of reinfusing viable tumor cells. Techniques to mitigate this risk include the use of leukocyte depletion filters, irradiation, and antibody-based treatments. Nonetheless, the exact oncologic burden of salvaged blood, in terms of tumor cell quantity, viability, proliferative capacity, migratory behavior, and metastatic potential, remains insufficiently characterized. Meta-analyses of observational studies suggest that oncologic outcomes in patients treated with IOCS are comparable to or better than those of patients treated with allogeneic blood transfusions. Yet, randomized controlled trials have not been performed yet due to missing preclinical evidence. This review aims to summarize the current evidence on the biology of remaining tumor cells in salvaged blood, evaluate the effectiveness of existing cell reduction strategies, and highlight key methodological challenges in quantifying and characterizing residual malignant cells. In addition, we spotlight recent advances in laboratory assays designed to detect circulating tumor cells (CTCs) in blood, particularly technologies developed for the analysis of intravascular CTCs. Given their similar methodological principles, these technologies offer promising tools for future safety assessments of IOCS in oncologic surgery.

Complete cytoreduction is a critical prognostic indicator for patients with colorectal cancer peritoneal metastases. This study aimed to identify pre-operative predictors of completeness of cytoreduction in patients with colorectal peritoneal metastases.

Proton pump inhibitors (PPIs) are widely used to treat cancer patients in different settings and have been found affect patient outcomes. However, the effect of PPI use during the radical resection of colorectal cancer (CRC) has never been addressed.

Large Hepatocellular Carcinoma (LHCC) are aggressive tumours characterized by a high risk of early recurrence (ER). Although several models predicting this risk exist for HCC, no one is specific for tumours ≥5 cm. The aim of this study is to develop classic and machine learning (ML) models able to identify patients with this pattern of recurrence.

Despite prior demonstration of a detrimental effect of post-mastectomy radiotherapy (PMRT) on patient reported outcomes (PROs) in patients with breast cancer (BC) undergoing breast reconstruction, the impact of PMRT on patients without reconstruction remains less clear. The objective of this study was to assess the association between PMRT and patient-reported outcomes (PROs).

Short-term gastric cancer surgery outcomes depend greatly on hospital surgical volume, whereas long-term survival studies show conflicting results. This study evaluated the effect of surgical volume on the long-term survival of patients who underwent surgery for gastric cancer in Slovenia.

Minimally invasive approaches to manage early-stage rectal cancer have become popular, offering effective treatment with reduced morbidity. Among them, transanal endoluminal surgery (TES) and endoscopic submucosal dissection (ESD) are widely utilized, yet their comparative outcomes from large-scale real-world data remain limited.

Most patients with curative oesophageal cancer undergo surgery. This invasive procedure affects the health-related quality of life. This study examined patient-reported outcomes in long-term survivors and the influence of sex and age.

To determine the extent of axillary disease in patients with non-palpable but preoperatively biopsy-proven positive nodes, and to identify predictors of extensive lymph node (LN) involvement, defined as ≥3 positive LNs (LN+).

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improve survival in appendiceal carcinoma (AC) with peritoneal dissemination. However, its role in patients with concurrent peritoneal and parenchymal lesions (stage IVc) remains unclear.

This study aimed to assess clinical outcomes and identify prognostic factors for time to surgical failure (TSF) following conversion hepatectomy in patients with initially unresectable colorectal liver metastases (CRLM).

Mismatch repair deficiency (MMRd) is a tumour-agnostic biomarker predicting response to immune checkpoint inhibition (ICI). Microsatellite unstable (MSI-H) colorectal cancers (CRC) display poor response to 5-Fluorouracil-based chemotherapy. ICIs demonstrate benefit in stage IV disease, but data on neoadjuvant ICI remain limited.

This ambispective cohort study aimed to explore the influence of surgeon age on long-term prognosis and surgical safety in esophagectomy patients, as well as in different surgical approaches.

Sarcopenia and adiposity at diagnosis are important prognostic factors in cancer. Ongoing changes in body composition during chemotherapy treatment may have additional prognostic relevance. This study aimed to investigate the association between body composition changes during neoadjuvant treatment and survival in patients with colorectal liver metastases.

To investigate the efficacy and safety of patients with primary intestinal lymphoma (PIL) who received either surgery first or chemotherapy first, aiming to provide robust evidence for clinical treatment.