Proton beam therapy (PBT) has a promising local control rate, but clinical data supporting its use for intermediate-stage hepatocellular carcinoma (HCC) remains insufficient, and its survival benefit over transarterial chemoembolization (TACE) has yet to be established. This study aimed to compare the two modalities by evaluating real-world survival outcomes.

Cone-beam computed tomography (CBCT) is a critical imaging modality in various medical fields, yet its repeated use poses radiation risks to patients. Low-dose CBCT image reconstruction aims to mitigate these risks while preserving image quality, which is crucial for clinical diagnosis and treatment. This review paper provides an in-depth analysis of the latest research progress in low-dose CBCT image reconstruction. We explore analytical reconstruction algorithms, iterative reconstruction algorithms, and deep learning approaches, each with distinct characteristics and applications. The paper comprehensively reviews the methods used for dose reduction in CBCT, the evolution of reconstruction algorithms, and their performance evaluations. We also identify challenges and limitations in current techniques, discussing potential future directions for low-dose CBCT reconstruction. Through a systematic literature search and analysis, this review offers a valuable reference for researchers and clinicians alike, aiming to advance the field of CBCT and enhance patient care through reduced radiation exposure and improved imaging outcomes.

Cancer registry data are an essential resource for population-based oncology research and quality assurance in Germany. With the revision of the Federal Cancer Registry Data Act in 2021, for the first time, a legal basis was created for the development of a nationwide clinical cancer dataset. This registry offers new opportunities for research, particularly in radiation oncology.

Treatment of advanced vulvar cancer is challenging. The aim of the study was to investigate the potential of primary (chemo)radiotherapy ((C)RT) with regard to clinical outcome and associated prognostic parameters.

Thie study aimed to examine the economic implications of different radiotherapy fractionation schemes, specifically normofractionation (NF) and hypofractionation (HF), for breast and prostate cancer in the outpatient setting of the German healthcare system. In times of workforce shortages, limited machine availability, and rising patient numbers, the study aims to identify which fractionation approach offers the highest value in terms of efficiency and economic sustainability, aligning with a value-based healthcare framework.

Computed tomography (CT) scans are vital for radiotherapy planning, providing essential data for dose calculations. This study retrospectively evaluated imaging doses, scan lengths, and protocol adherence to support imaging optimization and reduce patient radiation exposure.

To evaluate genitourinary (GU) toxicity in patients with prostate cancer receiving conventional radiotherapy (RT) with a simultaneous integrated boost (SIB) to intraprostatic lesions (IPL), with a specific focus on those with a history of transurethral resection of the prostate (TURP).

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by supramaximal immune activation. Although rare, HLH has been increasingly recognized as an immune-related adverse event in patients undergoing immune checkpoint inhibitor (ICI) therapy.

Lymphedema of the arm and reduced shoulder mobility are common complications of breast cancer treatment. We aim to establish whether the radiation dose received by the area of the axillary lateral thoracic artery vessel juncture (ALTJ) and the shoulder joint-affect the development of the mentioned side effects.

Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules that control the expression of target mRNAs. Many miRNAs are dysregulated in various cancers, acting as tumor suppressors or oncogenes. This study aims to investigate the regulatory status of miRNA-320a-3p and miRNA-136-5p in cervical cancer development as well as their predictive significance for treatment response and disease recurrence.

Financial toxicity (FT) associated with cancer and its treatment has become increasingly important. This study investigated factors associated with the development of FT during radiation therapy (RT). SOCOFIN was the first longitudinal prospective study to systematically evaluate FT in the context of RT.

Ventricular tachycardia (VT) is a life-threatening condition, and standard treatments are not suitable for many affected patients. Stereotactic arrhythmia radioablation (STAR) has emerged as a promising experimental last-resort treatment for patients with refractory VT, but it lacks clinical standardization. To address this issue, the STOPSTORM.eu consortium aims to collect data on patients treated with STAR via the development of a multicentric patient registry. The Ethics & Regulations Working Group (ERG) provides support addressing ethical and regulatory challenges.