This review aims to provide a comprehensive overview of mavacamten in the management of obstructive hypertrophic cardiomyopathy (oHCM), from its molecular mechanism of action to clinical trial outcomes and real-world application. It explores the efficacy, safety, and practical considerations of mavacamten use, while highlighting evolving indications and future directions.

To summarize and provide insight into the role of exercise rehabilitation for heart failure, cardiomyopathies and associated conditions. We provide an overview of the evolution of exercise training from "bed rest" to current guidelines and highlight emerging approaches.

Titin-related cardiomyopathy (TTN CMP) is the most prevalent genetic cause of dilated cardiomyopathy (DCM), yet its clinical variability and incomplete penetrance challenge risk stratification and therapeutic management. This review aims to summarize recent insights into the genetic, molecular, and clinical aspects of TTN-CMP, emphasizing its heterogeneity and the implications for diagnosis, prognosis, and treatment.

To understand the growth of the adults with congenital heart disease (ACHD) population and ACHD work force needs in the United States, and to consider solutions to provide access for this population.

To describe recent advances in knowledge of familial hypercholesterolemia (FH).

Mitral regurgitation is a common and heterogeneous valve disease, with its prevalence increasing due to aging populations. This review aims to provide a comprehensive overview of the roles of transthoracic (TTE) and transesophageal echocardiography (TEE) in the evaluation of mitral regurgitation (MR).

This review aims to provide a comprehensive contemporary overview regarding the clinical perspectives, multi-modality imaging evaluation, treatments and outcomes of subaortic stenosis (SAS).

The diagnostic, therapeutic, and prognostic management of patients with suspected acute coronary syndrome (ACS) is a major challenge for clinicians in both emergency and outpatient settings. While clear-cut cases of acute myocardial infarction typically require immediate invasive coronary angiography (ICA), more nuanced and complex presentations require careful selection of the most appropriate diagnostic tests to determine the underlying cause of symptoms. This narrative review aims to delineate specific scenarios in which non-invasive multimodal imaging techniques-such as transthoracic echocardiography (TTE), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), and nuclear imaging-are appropriate and optimal in the setting of ACS.

This paper examines how digital health technologies can either reduce or exacerbate disparities in cardiovascular disease outcomes. It explores the role of the digital divide defined as a multifactorial phenomenon encompassing unequal access to internet connectivity, digital devices, and digital literacy, often driven by socioeconomic status, geography, age, education, language, and disability in shaping access to telehealth, remote monitoring, and patient engagement tools, with a focus on strategies for equitable implementation.

Ultrasound-targeted microbubble cavitation (UTMC) has emerged as a transformative non-invasive technology in diagnostic imaging, therapy, and targeted gene and drug delivery. As UTMC advances toward clinical translation, understanding its impact on fundamental cellular functions is essential.

To summarize the key features of vulnerable plaques identified by intracoronary and non-invasive imaging and explore how anti-atherosclerotic therapies contribute to plaque regression and stabilization.

To provide clinicians with a concise introduction of microplastics potential role as a cardiovascular risk factor.

Accurate, timely quantification of cardiac function is central to the diagnosis, management, and monitoring of cardiovascular disease. This review synthesizes recent advances in artificial intelligence (AI) applications across the major data modalities used in cardiovascular medicine, spanning electrocardiography (ECG), echocardiography, cardiac CT/MRI, and clinical text in electronic health records (EHR).

Epicardial adipose tissue (EAT), the visceral fat of the heart, is highly inflammatory fat depot with pro-inflammatory transcriptome and proteosome. EAT contributes to the development and progression of coronary artery disease (CAD) and atrial fibrillation (AF) through multifactorial inflammatory pathways. However, the paradigm linking EAT inflammation and cardiovascular risk was recently reevaluated.

Wearable cardioverter-defibrillators (WCDs) offer a non-invasive, temporary safeguard against sudden cardiac death in patients with transient high-risk conditions, but real-world prescribing is highly variable due to inconsistent evidence of benefit. This review examines current WCD evidence and guideline recommendations, highlighting recent clinical findings, international guideline discrepancies, health economic data, and controversies underlying heterogeneous prescribing practices.

Energy drinks are widely marketed to enhance alertness and performance, making them a rapidly growing industry valued at $73.99 billion. These beverages typically contain caffeine and other stimulants, but their consumption has raised concerns about potential cardiovascular risks, including arrhythmias, tachycardia, and hypertension, particularly among young adults. While moderate caffeine intake may offer health benefits, excessive consumption of energy drinks has been linked to increased cardiovascular risks. This systematic review aims to explore the cardiovascular effects of energy drink consumption, identify knowledge gaps, and guide clinicians in making recommendations.

This review examines the growing role of extended reality (XR) (including virtual, augmented, and mixed reality) in the care of patients with congenital heart disease (CHD), with a focus on its use in patient education, trainee instruction, and procedural planning.

To summarize the recent literature examining the degree of overlap among atrial fibrillation (AF), heart failure (HF), and left atrial (LA) dysfunction, the prognostic relevance of finding a second condition in one of the other disease states, and the treatment effects for one condition on the secondary entities.

This paper aims to clarify the mechanism of action of Cardiac Contractility Modulation in heart failure treatment, synthesize key clinical evidence supporting the combination of Cardiac Contractility Modulation and implantable cardioverter-defibrillators for managing heart failure with reduced ejection fraction, and explore potential challenges and future applications pertaining to this combined therapy.

This review aims to provide an updated overview of the clinical management of heart failure and comorbidities in transthyretin amyloid cardiomyopathy (ATTR-CM). We sought to address key unanswered questions and current uncertainties regarding treatment response, prognosis, and optimization of care in this complex population.

This review summarizes current 2D and 3D echocardiographic techniques for evaluating right heart structure and function in pulmonary hypertension (PH), emphasizing their diagnostic, prognostic, and monitoring roles. It also highlights the emerging role of myocardial strain imaging and right atrial (RA) assessment in comprehensive right heart evaluation.