Diquat-induced toxic brain injury is a challenging clinical issue, characterized by oxidative stress and neuroinflammation, which causes extensive damage to the central nervous system and has a poor prognosis.

Acetonitrile causes potentially fatal inhibition of cytochrome c oxidase. We report a mass poisoning event linked to consumption of alcohol adulterated with acetonitrile.

Epidemiological and toxicological data available on patients exposed to bromazolam are limited. We report a case series of 32 patients presenting with bromazolam-positive urines.

The intensive care requirement score was developed to predict the need for intensive care unit admission in acutely intoxicated patients. However, as the score was originally derived from a cohort already admitted to intensive care, its performance in emergency department populations remains uncertain. This study evaluates its performance in that setting.

Antipsychotic medications are often associated with QT interval prolongation, which can lead to ventricular dysrhythmias, including torsade de pointes. However, unstable or significant dysrhythmic events are rare. Evidence-based recommendations on the assessment and management of poisoned patients at risk for QT interval prolongation are lacking. Current practice often involves costly and lengthy cardiac monitoring, leading to delayed disposition of the patient from emergency departments or prolonged monitoring times in other hospital units. To address this issue, the QT Interval Prolongation in Clinical Toxicology Workgroup was formed by the Clinical Toxicology Recommendations Collaborative to develop evidence-based recommendations for the management and treatment of QT interval prolongation in acute overdose patients. This article reports our findings on patients with antipsychotic poisoning.

Wearing personal protective equipment that provides more protection than is necessary compromises the effectiveness of medical procedures. Using simulants, we aimed to assess the risk of secondary exposure in the operating room during surgery on patients with mustard-contaminated penetrating wounds.

Aluminium phosphide is a highly toxic fumigant pesticide that releases phosphine upon contact with moisture. Phosphine primarily targets the cardiovascular system and may result in multi-organ failure.

Toxicology is a critical yet often underemphasized component of medical curricula. We developed , an interactive computer game designed to teach core toxicology principles.

Antidysrhythmic medications are commonly prescribed, but there is little information on the incidence of adverse effects following an inadvertent extra dose of these medications. This poses a challenge to poison centers when trying to decide which patients need to be sent to a healthcare facility for monitoring.

Prior studies suggest metformin exposures in young pediatric patients are low risk, and a triage threshold of 85 mg/kg can be used to reduce unnecessary evaluations. Our objective was to analyze single-substance metformin exposures using the National Poison Data System to describe the clinical course, outcome, and mg/kg dose of metformin exposures in children under six years old. The secondary objective was to describe outcomes in patients divided into safe (≤85 mg/kg reported dose) and caution (>85 mg/kg reported dose) categories.

Diisopropylcarbodiimide is a peptide coupler commonly used in biotechnology. Dermal and respiratory effects, due to irritant and sensitizing properties, have been reported in exposed workers and experimental studies. Neurological toxicity, as demonstrated in animal studies, has not been reported in humans. We describe three male workers who experienced dermal, respiratory, and neurological sequelae after accidental exposure to diisopropylcarbodiimide, a volatile liquid product.

Methanol is ubiquitous, and early intoxication mimics other conditions. The prevalence of occult methanol intoxication is unknown. The goal of this study is to determine the frequency of unexpectedly positive methanol concentrations in patients at an urban safety net hospital with real-time testing capabilities, and to evaluate the clinical significance of these findings.

Extracorporeal membrane oxygenation is an important therapeutic option for the critically ill poisoned patient, but data are limited mainly to case reports and case series. A lack of thorough reporting of specific extracorporeal membrane oxygenation details or the resultant physiological response may lead to misinterpretation of the effectiveness of extracorporeal membrane oxygenation, limiting its generalizability.