Asthma, a chronic inflammatory disease characterized by inflammation and immunological abnormalities, was the focus of this study, which explored the mechanisms and efficacy of a pediatric anti-cough and asthma sirup in a cigarette smoke extract (CSE)-induced rat asthma model.

The adherence to methotrexate (MTX) prolonged therapy in various cancers and autoimmune disorders is restricted due to its deleterious effects on several organs, like the liver, kidney, and intestine. Farnesol (FAR), a sesquiterpene alcohol found in various foods, essential oils, and herbs, exhibited promising antioxidant and anti-inflammatory impact in diverse experiments. The purpose of our study was to examine the possible mitigation of MTX-induced intestinal damage by FAR and the molecular pathways involved.

Acute lung injury (ALI) represents a diverse clinical condition characterized by significant complications and death rates. Naftidrofuryl (NAF) is a vasodilator drug with reported anti-inflammatory properties.

Moscatilin has been shown to effectively suppress inflammation in macrophages in mice treated with concanavalin A (ConA). However, further investigation is needed to fully elucidate the specific underlying mechanisms.

Leonurine (Leo) has antioxidant and anti-inflammatory activities. In this study, we investigated the effect of Leo in a rat model of lipopolysaccharide (LPS)-induced chronic obstructive pulmonary disease (COPD).

Our goal was to assess if febuxostat (FEB) could prevent ovarian damage caused by cyclophosphamide (CP).

As a highly aggressive form of breast cancer, triple-negative breast cancer (TNBC) is characterized by significant metastatic potential, a lack of targeted therapies, and an unfavorable prognosis. Tussilagone (TUS), a bioactive sesquiterpene isolated from Tussilago farfara's medicinal herb, has shown anti-inflammatory and anticancer properties. However, its potential role in TNBC treatment and the underlying molecular mechanisms remain unexplored.

Voclosporin was approved from the United States Food and Drug Administration (FDA) for treating adults with active lupus nephritis, in combination with a background immunosuppressive therapy regimen. Due to the limitations of clinical trials, real-world safety data on voclosporin in large samples are currently lacking. Therefore, this study aims to evaluate adverse events (AEs) associated with voclosporin.

Successful pregnancy relies on the healthy completion of implantation, decidualization, and placentation. Additionally, the balance of the inflammatory response is crucial in processes such as trophoblast invasion, tissue, and vascular remodeling.

Polydatin, a natural component of Polygonum cuspidatum, exhibits potent anti-metabolic properties. The treatment with Poly (10 µm/L) effectively reversed the high glucose (HG)-induced reduction in acetylcholine (ACh)-elicited vasodilation in the aortas of Sprague-Dawley rats.

Cancer cells often overexpressed specific receptors to support their proliferation and promote immunosuppressive tumor microenvironment. Tropomyosin receptor kinase C (TrkC) is known to be overexpressed in cancer, and implicated in promoting tumor progression and metastasis. This study investigates synergistic efficacy and immunomodulatory effect of a peptidomimetic TrkC-targeted ligand (IYIY) conjugated with dinitrophenol (DNP) hapten (IYIY-DNP), in combination with cyclophosphamide (CTX), an alkylating chemotherapeutic with immune-modulating properties.

This study aimed to investigate the impact of magnoflorine (Mag) on acute exercise-induced fatigue and its underlying mechanisms.

The increasing use of silica nanoparticles (SiNPs) has raised concerns about their hazards to human health. However, immunotoxic effect remains insufficiently explored.

The complex interaction between the adaptive immune system and innate immunological components causes rheumatoid arthritis (RA), a systemic autoimmune disorder that involves synovitis and joint deformity. Brain- spleen axis is a reciprocal cross-communicative circuit serves a crucial role in maintaining immunomodulation and homeostasis. RA complicates extra-articular manifestations in spleen and brain. Exposure to ionizing radiation might exacerbate the severity of RA. Recently, beta- sitosterol (BS), which is a promising phytosterols, has shown efficacy against various inflammatory models.

Edaravone dexborneol is an agent used to treat patients with acute ischemic stroke (AIS); however, the underlying mechanisms of this drug remain unclear.

Immunotherapies, including chimeric antigen receptor T-cell (CAR-T) therapy, represent a pivotal approach in the treatment of multiple myeloma (MM). However, the complex immunosuppressive tumor microenvironment (TME) poses significant challenges to their efficacy. Among the immunosuppressive cells in the MM TME, granulocytic myeloid-derived suppressor cells (G-MDSCs) are predominant, yet their functions remain incompletely understood. This study aimed to comprehensively analyze the role of G-MDSCs in MM patients undergoing CAR-T therapy.

Sepsis-induced cardiotoxicity (SIC) is a critical complication characterized by inflammation, oxidative stress, and apoptosis, leading to myocardial dysfunction. The short-acting opioid analgesic remifentanil (REMI) possesses antioxidant and anti-inflammatory properties. This study aimed to evaluate the cardioprotective effects of REMI on lipopolysaccharide (LPS)-induced SIC by examining inflammation, oxidative stress, apoptosis, and mitochondrial function.

Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease whose pathogenesis is closely related to the imbalance between regulatory T (Treg) and T helper 17 (Th17) cells. Rebuilding the Treg/Th17 balance provides a potential therapeutic approach for AIH patients. All- retinoic acid (atRA) sustains Treg cell function while inhibiting pathogenic Th17 cell differentiation. This study explored the potential of atRA for treating experimental AIH (EAH).

Esophageal cancer (ESCA) is a pervasive health threat, and cancer driver genes (CDGs) are under investigation as potential biomarkers for its treatment.