To characterize real-world prescribing patterns, perceived barriers, and clinician attitudes toward the recently introduced (July 2024) promising long-acting growth hormone (LAGH) somatrogon for treating pediatric growth hormone deficiency (GHD) in Israel.

Familial hypercholesterolemia (FH), characterized by elevated serum cholesterol concentrations from birth onwards, is inherited in an autosomal dominant manner and is classified into heterozygous FH (HeFH) and homozygous FH.

Young adults with diabetes face unique challenges in care. We aimed to assess the feasibility of the Diabetes Collaborative Care for Young Adults (DCCYA), a multidisciplinary care model tailored to young adults.

The pyramidal lobe (PL), a normal yet highly variable anatomical structure of the thyroid gland. Current literature suggests that 10% to 30% of patients undergoing total thyroidectomy (TT) exhibit residual PL tissue, which may compromise the completeness of cancer resection, hinder postoperative radioiodine therapy, and impact serum thyroglobulin levels. Notably, major guidelines from the American Thyroid Association, European Society for Medical Oncology, National Comprehensive Cancer Network lack specific recommendations regarding PL management. This study evaluates its role and necessity in TT, particularly in papillary thyroid carcinoma (PTC).

Despite recommendations by major diabetes organizations, medical nutrition therapy (MNT) in pediatric type 1 diabetes (T1D) remains underutilized. Suboptimal prandial practices and limited engagement in nutritional counseling with the diabetes care team may impact health outcomes in these youth. This study aimed to understand patient and caregiver experiences with and barriers to MNT utilization.

Metformin is a widely used, safe, and effective antidiabetic agent; however, its use in solid organ transplant (SOT) recipients has been limited. We aimed to evaluate the safety and cardiovascular, renal, and metabolic outcomes associated with metformin use in a large, real-world cohort of SOT recipients living with diabetes.

Transitions of care at hospital discharge are critical time periods for people with diabetes, but little is known about glycemia in the immediate post-discharge period.

Tirzepatide shows benefits on cardiovascular (CV) parameters and major adverse cardiovascular events (MACE) in clinical trials, but real-world data, especially for type 2 diabetes (T2D), are limited. This systematic review and meta-analysis seeks to address this gap.

To examine how weight status influences insulin-like growth factor-1 (IGF-1) levels and growth outcomes in short statured children treated with growth hormone (GH) for GH deficiency or idiopathic short stature.

Bilateral adrenal venous sampling (AVS) is critical for accurate primary aldosteronism (PA) subtype differentiation and treatment planning; however, its complexity and invasiveness limit its widespread adoption. We tested a less invasive simultaneous bilateral AVS via right cubital vein using 2 4F MPA1 catheters to improve practicality/safety.

Menopause hormone therapy (MHT) recommendations have changed significantly over the last 30 years. Early observational studies suggested that MHT offered broad benefits for women, including relief from menopausal symptoms, improved genitourinary health, prevention of osteoporosis, and reduction in cardiovascular disease. As randomized controlled trials were conducted to validate these findings, new evidence emerged that led to shifts in guidance from medical societies and sharp declines in MHT prescriptions.

The prevalence of hypercortisolism in hypertension and its association with cardiometabolic risk in hypertensive patients remains unknown. This study investigates the prevalence of hypercortisolism and the relationship between cortisol secretion and cardiometabolic parameters in hypertensive patients.

Cushing syndrome (CS) is characterized by excess cortisol and distinct facial features, including moon face and facial fat accumulation. However, facial fat distribution differences between CS and common obesity remain unclear. This study used 3-dimensional photogrammetry to quantify facial characteristics influenced by cortisol.

Primary aldosteronism (PA) is a clinical syndrome caused by endocrine disorders. This study developed a risk prediction nomogram model for patients with PA based on least absolute shrinkage and selection operator (LASSO)-logistic regression and evaluated the predictive performance of this nomogram model.

For treatment of hyperparathyroidism, accurate detection of potential parathyroid adenomas is crucial prior to surgical removal. Fluorine-18-fluorocholine (FCH) positron emission tomography (PET)/computed tomography (CT) has emerged as an alternative to previous imaging procedures, and literature shows superior diagnostic performance. This study aimed to evaluate FCH-PET/CT as a first-line procedure for localizing potential parathyroid adenomas in a real-world setting and establish benefits and challenges of adopting this procedure.

Heterogeneity in the clinical course of type 2 diabetes in youth presenting with and without diabetic ketoacidosis (DKA) at diagnosis is not well described. We aimed to characterize if presentation of type 2 diabetes with DKA affects rates of insulin discontinuation compared with type 2 diabetes without ketosis (non-DKA).

This umbrella review aims to comprehensively evaluate the effects of weight loss and various weight loss interventions, like bariatric surgery, dietary modifications, and physical activity, on sex hormone profiles in adults. The goal is to synthesize existing systematic reviews and meta-analyses to clarify the impact of different weight loss strategies on sex hormones.

Endogenous Cushing syndrome is associated with an intrinsic hypercoagulable state and an increased risk of venous thromboembolism (VTE). This study aimed to determine the prevalence and risk factors for VTE in a large cohort of patients with Cushing disease (CD).

This review aimed to: (i) summarize the clinical evidence for automated insulin delivery (AID) use during pregnancy in people with pregestational diabetes, (ii) provide an overview of AID systems available in the US, and (iii) offer practical tips and considerations for clinicians working with pregnant patients on these systems. We synthesized findings from all six randomized controlled trials investigating AID use in people with pregestational type 1 diabetes. Some demonstrated better glycemic outcomes in patients using AID compared to sensor-augmented pump (SAP) therapy or standard insulin therapy. Others found no significant differences. Maternal and neonatal outcomes were similar to standard care, though some studies found that AID users had reduced gestational weight gain among other improvements. We also compared the features of six AID systems and shared clinical insights on how their settings can be adjusted to better meet pregnancy-specific glycemic targets. CamAPS FX is the only FDA-cleared AID system for use in T1D pregnancy, though it is not yet available in the US. While no AID system has demonstrated the ability to meet all pregnancy-specific glycemic targets, some systems are more customizable, making it easier to achieve the tighter glycemic targets in pregnancy. In conclusion, for pregnant women using AID systems, there are strategies and workarounds to aid in achieving pregnancy-specific glycemic targets. However, no system consistently meets all targets. More research is needed to understand how AID use during pregnancy impacts maternal and fetal outcomes and patient-reported outcomes, especially for pre-existing type 2 diabetes.