Cuproptosis is a type of cell death caused by copper imbalance associated with the growth and proliferation of cancer cells. Long noncoding RNAs (lncRNAs) play a crucial role in hepatocellular carcinoma (HCC) development. Here, we aimed to investigate the role of cuproptosis-related lncRNAs in the clinical prognostic prediction and immunotherapy for HCC.

While the Eosinophilic Esophagitis (EoE) has become the second most common disease entity causing esophageal dysfunction, there is currently a lack of data reporting on pediatric EoE from Germany. This monocentric longitudinal study seeks to fill this gap by investigating treatment success, atopic comorbidities and potential blood parameters in a real-world setting.

Risk factors for rectal neuroendocrine tumors (NETs) have not been reported in a cohort setting, although their association has been reported in cross-sectional studies. We investigated the sex-specific risk factors for rectal NETs.

Leukoaraiosis, common focal lesions, are associated with cognitive impairment, gait abnormalities and depression. Helicobacter pylori is an intragastric pathogen that has been implicated in extraintestinal disease. This study explored the relationship between leukoaraiosis and Helicobacter pylori infection, and analyzed the Helicobacter pylori infection in different white matter lesion sites.

Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic immune-mediated disorders that significantly impact patients' quality of life. Proper IBD management often requires invasive diagnostic procedures such as endoscopy. Transabdominal intestinal ultrasound (IUS) offers a promising alternative due to its non-invasive, inexpensive, and widely available nature. This study aims to evaluate the effectiveness of IUS combined with clinical parameters in guiding treatment decisions for IBD patients in remission or relapse.

Despite advances in pharmaceuticals, managing ulcerative colitis (UC) remains challenging. Interest in fecal microbiota transplantation (FMT) for UC is growing, but varying formulations and endpoints in trials complicate safety and efficacy assessment. This systematic review and meta-analysis offer a validated, up-to-date overview of FMT's efficacy and safety in UC.

Cancer remains a leading cause of mortality worldwide. Chemotherapy serves as a cornerstone of cancer treatment, providing significant benefits in tumor control and survival. However, its therapeutic efficacy is often compromised by gastrointestinal toxicity, which impairs quality of life and may necessitate treatment modifications. Disruption of the gut microbiota has been recognized as a key factor in the development of these toxicities.

The management of Crohn's disease (CD) in older-adult patients is challenging due to age-related immune decline, comorbidities, and the excessive risk of adverse effects from pharmacological treatments. The Crohn's Disease Exclusion Diet (CDED) has shown promise in treating younger populations, but its effectiveness in older-adults remains understudied. This study aimed to evaluate the CDED effectiveness in older-adults with CD.

Green tea polyphenols (GTPs) and aspirin were demonstrated to be novel candidates for cancer chemoprevention. This study aimed to investigate effects of GTPs and aspirin on esophageal diseases.

The association between chronic Helicobacter pylori infection and hormone levels affecting food intake and obesity remains controversial. Thus, our aim was to investigate the long-term effect of H. pylori eradication on changes in ghrelin and leptin levels in correlation with histologic analysis of the gastric mucosa.

Budd-Chiari syndrome is defined as the obstruction of hepatic venous flow. Limited evidence exists in Colombia regarding the characterization of these patients. This study aimed to describe the clinical characteristics, management, and survival of patients diagnosed with Budd-Chiari syndrome in a Colombian hepatology referral center from 2010 to 2022.

Periampullary masses encompass both benign and malignant lesions that are clinically challenging to differentiate. This study aimed to investigate the diagnostic value of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) for periampullary masses and compare its performance with computed tomography (CT) and magnetic resonance imaging (MRI).

This meta-analysis evaluates efficacy and safety of anti-reflux mucosal interventions (ARMIs) for gastroesophageal reflux disease (GERD), and comparative effectiveness against traditional interventions.

Acute pancreatitis is a significant complication of endoscopic retrograde cholangiopancreatography (ERCP) with no established prevention strategy. Recent studies suggest that rectal indomethacin may reduce the incidence of post-ERCP pancreatitis (PEP), but its effectiveness varies with patient risk levels and the concurrent use of pancreatic stenting. This updated meta-analysis evaluates the efficacy of rectal indomethacin in preventing PEP.

Universal screening of hepatitis C virus (HCV) was encouraged for individuals born 1945-65 in the USA in 2012. In 2014, efficacious treatments, namely, direct-acting antivirals (DAAs), were introduced. To examine their impact on the HCV care cascade, the proportion of and factors associated with delayed HCV diagnosis in the USA were examined in a national real-world cohort.

The RHEMITT score (RS) has showed an excellent accuracy to predict rebleeding after video capsule endoscopy (VCE), in patients with small bowel bleeding (SBB). However, RS was developed and subsequently validated in a heterogeneous population of patients with overt and occult SBB. As the bleeding presentation is a recognized independent predictor for rebleeding, the aim of this study was to assess the RS utility in a homogeneous cohort of patients admitted with only overt SBB.

Endoscopic retrograde cholangiopancreatography (ERCP) is the standard treatment for choledocholithiasis. However, elderly patients, particularly those aged ≥80 and ≥90, may face higher risks of complications due to comorbidities and age-related anatomical changes. This meta-analysis aimed to evaluate the efficacy and safety of ERCP in this population.

Colonoscopy is a common procedure that requires adequate bowel preparation. Polyethylene glycol (PEG) is widely used but commonly associated with patient complaints, including the split-dose administration schedule. Mannitol could be an attractive alternative as it acts quickly, requires low volumes, and is palatable. A recent Phase III international, multicenter, randomized study (SATISFACTION) compared the efficacy and safety of bowel preparation using same-day oral mannitol or a split-dose regimen of 2L PEG-ASC. This study investigated the effects of the two laxatives on the Bowel Cleansing Impact Review (BOCLIR), a questionnaire exploring the degree of satisfaction of patients undergoing preparation for a colonoscopy.

Introduction: Dose escalation with biologics is common among patients with ulcerative colitis (UC). We investigated the dose escalation and associated incremental costs among patients treated with biologics for UC.

Gut microbiota plays a critical role in health and may contribute to post-COVID manifestations, as alterations in microbial communities have been observed in affected individuals. This study aimed to identify microbial and biochemical signatures in post-COVID individuals after an extended period following acute infection.