Acceptability of active and sham home-based transcranial direct current stimulation in major depression: mixed methods qualitative analysis in a randomised controlled trial
Transcranial direct current stimulation (tDCS) is a novel non-invasive brain stimulation therapy that is a potential treatment for major depressive disorder (MDD). Acceptability impacts patient preference, treatment adherence and outcomes, however, it has typically been assessed through measures of attrition, self-reported satisfaction levels, or adverse events. We sought to explore participant acceptability using structured questionnaires and individual interviews.
Mental health of children in high-altitude regions: a bibliometric study and visualization analysis from 1979 to 2024
Children's mental health in high-altitude areas is influenced by various environmental, socioeconomic, and biological factors. This study aims to explore the knowledge framework and key research areas in this domain, using bibliometric methods to analyze trends, collaboration patterns, and essential themes related to children's mental health at high altitudes.
Vortioxetine effectiveness in the treated major depressive disorder patients in Saudi Arabia
Major Depressive Disorder (MDD) is a prevalent mental health condition characterized by persistent feelings of sadness, loss of interest or pleasure, and a range of physical and cognitive symptoms. Despite the availability of various treatment options, many MDD patients continue to experience significant impairment in their daily lives.
The burden of anxiety, depression, and substance use disorders attributable to childhood maltreatment among adolescents in Africa: insights from the global burden of disease study 2021
Childhood maltreatment is a major risk factor for mental and substance use disorders particularly among adolescents however, there's no comprehensive report of its attributable burden on anxiety, depression, and substance use disorder in Africa. This research sort to delineate the Disability-adjusted life years (DALYs) trend and age-period-cohort effects on these disorders attributable to childhood maltreatment among 10-24-year-olds in Africa.
Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis
The study assesses proinflammatory factors in major depressive disorder (MDD) patients with and without suicidal behaviors, and healthy controls, to identify potential biomarkers for suicidal behaviors and prevention strategies.
Smoking status and the onset of suicidal ideation among adults in Japan during the COVID-19 pandemic
As previous research has linked smoking to suicidal behavior, it is possible that smoking may have played a role in suicidality during the COVID-19 pandemic. However, relatively little research has examined this association. To address this gap, the present study examined the relationship between smoking status and the onset of suicidal ideation in Japan during the pandemic.
Anomalous self-experience in substance-induced and primary psychotic disorders: a cross-sectional comparative study using the EASE interview
Disturbances of the minimal self, or anomalous self-experiences (ASEs), are increasingly regarded as a core feature of primary psychotic disorders (PPDs). However, it remains unclear whether similar self-disorders are present in substance-induced psychosis (SIP), a condition that often mimics PPDs in its early stages.
Efficacy of acupuncture for generalized anxiety disorder: a systematic review
This systematic review aimed to assess the efficacy and safety of acupuncture for generalized anxiety disorder (GAD), with a particular focus on acupuncture alone and acupuncture combined with medication, compared with medication or sham acupuncture.
Pet ownership and risk of depression: a systematic review and meta-analysis
Pet ownership is often believed to confer psychological benefits, such as reducing loneliness and providing emotional support. However, evidence on its relationship with depression is mixed, and no clear consensus currently exists. This systematic review and meta-analysis aimed to evaluate the association between pet ownership and the risk of depression.
The association between sleep onset time and depression among U.S. adults: a cross-sectional study from NHANES 2015-2020
The link between sleep onset time and depression is not well understood. We aimed to investigate the association of sleep onset time with depression.
Perinatal depression and anxiety symptoms as mediators between grief and PTSD: the moderated effect of social support
Posttraumatic stress symptoms are prevalent mental phenomenon in women with previous perinatal loss due to high grief, high perinatal depression and anxiety or low social support. Although posttraumatic stress symptoms are known to have serious negative implications for women with previous perinatal loss, families and society, the mechanism through which it functions is less clear.
Effect of lacticaseibacillus paracasei PS23 on anxiety and sleep difficulties among office workers: a double-blind, randomized controlled pilot trial
Over the past decade, sleep disturbances and stress have markedly increased within the general population. Conditions such as insomnia and poor stress management are linked to a range of physical and psychological symptoms, including cardiovascular diseases, sleep disorders, depression, or anxiety. Recent studies have shown that heat-treated Lacticaseibacillus paracasei PS23 (PS23) can alleviate anxiety in clinical nurses experiencing high stress. However, the potential benefits of live PS23- particularly its effects on sleep quality, anxiety, and stress- remain unexplored.
Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters
Theoretical hypotheses suggest differing oxidative stress levels in mood disorders. We evaluated eight oxidative stress-related biochemical markers for further verification in first-onset patients with bipolar disorder (BD) or major depressive disorder (MDD).
Efficacy and safety of Bifidobacterium combined with high-frequency repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: a preliminary randomised controlled trial
This study aimed to explore the efficacy and safety of Bifidobacterium combined with high-frequency repetitive transcranial magnetic stimulation (rTMS) in treating depression in adolescents.
A novel approach to exploring youth non-suicidal self-injury heterogeneity: individual differential psychopathology network analysis
Non-suicidal self-injury (NSSI) is a common behavioral problem among children and adolescents. Previous studies of NSSI have been mostly group-based and lacked specific characterization of individuals with NSSI.
Mitochondrial dysfunction, a new marker warning of neuropsychiatric disorder risk: evidence from genetics and epidemiology
Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of neuropsychiatric disorders, but its causal role remains unclear. Mitochondrial DNA copy number (mtDNA-CN) and methylmalonic acid (MMA) are well-recognized biomarkers of mitochondrial function, but their association with psychiatric disorders has not yet been fully assessed.
A multi-level exploration of the genetic basis between lung cancer and schizophrenia
The relationship between schizophrenia (SCZ) and lung cancer (LC) remains inadequately understood, necessitating further exploration through a genetic perspective.
Exploring physicians' emotional reactions to suicidal patients: the impact of physician- and patient-related issues
The physician-patient relationship is essential in the care of suicidal patients, yet factors shaping this relationship remain insufficiently explored. This study aimed to explore physicians' emotional reactions to suicidal patients and how both physician- and patient-related issues influence these responses.
Mental health spending in Colombia: an analysis of rural and urban areas
Mental health expenditures are increasing worldwide. In developed countries there is evidence that increased health spending is associated with improved outcomes. However, this information may not apply to the Colombian health system that is significantly different and underfunded in comparison with developed countries.
Time to efficacious steady state plasma concentrations with slow titration of Vortioxetine drops versus oral tablets: a Pharmacokinetic model
The antidepressant vortioxetine is available as an immediate-release (IR) tablet formulation and as a bioequivalent oral drops solution (20 mg/mL) to allow personalised titration.
Treatment-resistant depression with poor response to deep brain stimulation improves with psychotherapy: case series
Deep brain stimulation (DBS) is regarded as an efficacious treatment for treatment-resistant depression (TRD), exhibiting a response rate of approximately 60%. However, certain patients exhibit limited responsiveness to DBS, necessitating further exploration of alternative interventions. In this paper, we present two cases of TRD patients who exhibited poor response to DBS surgery but showed significant improvement after receiving psychotherapy.
