[This corrects the article DOI: 10.2147/DMSO.S525774.].

Childhood obesity is associated with both short-term and long-term health complications, yet a new obesity phenotype called metabolically healthy obesity (MHO) has emerged. While MHO is often perceived as a "benign" form of obesity, research specifically examining health disorders risks in children with MHO remains limited. This systematic review and meta-analysis aimed to evaluate health disorders in children with MHO.

The pathogenesis of diabetic nephropathy (DKD) remains unclear; however, existing literature suggests that ectopic fat deposition and metabolic reprogramming contribute to the development of diabetic renal fibrosis. Our previous studies have demonstrated that pigment epithelium-derived factor (PEDF) can alleviate diabetic renal fibrosis.

To investigate whether the imbalanced aldosterone to renin ratio (ARR) is associated with renal micro-vasculopathy in type 2 diabetes mellitus (T2DM).

To investigate how lifestyle interventions alter fat distribution and organ-specific iron deposition in individuals with obesity, and whether these changes can serve as indicators of glycemic remission in obese patients with dysglycemia.

Diabetes mellitus is an escalating public health issue globally, with Africa facing a heavy burden due to weak health systems and scarce resources. In Somalia, limited data and deep-rooted cultural perceptions significantly influence disease understanding and management.

To investigate the associations of C-peptide-based insulin resistance index (HOMA2 IR-CP) and triglyceride-glucose-body mass index (TyG-BMI) with metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with type 2 diabetes mellitus (T2DM), identify independent risk factors for MASLD, construct a clinical predictive model, and evaluate its predictive performance.

Tsukushi (TSK) is a recently identified hepatic factor that has gained prominence for its distinctive function in glycolipid metabolism and energy homeostasis. However, the role of TSK in gestational diabetes mellitus (GDM) remains largely unexplored. In this study, we conducted a pioneering investigation by determining serum TSK levels in patients with GDM and examining the correlation between these levels and various metabolic parameters in gestational diabetes patients.

The mechanisms governing dynamic regulation of counterregulatory hormones in type 1 diabetes (T1DM) remain incompletely understood. To eliminate potential confounding effects of female sex hormones and menstrual cycle variations on insulin sensitivity and counter-regulatory hormone secretion, this study investigated the correlation between counter-regulatory hormone levels and insulin resistance in male patients with T1DM.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent condition, with gut microbiota dysbiosis playing a contributory role in its pathogenesis and progression. Fecal microbiota transplantation (FMT) has emerged as a potential therapeutic approach for MAFLD. This report describes two patients diagnosed with MAFLD who underwent FMT in combination with lifestyle intervention. Post treatment findings demonstrated notable improvements in body mass index (decreased by 20.7% and 3%, respectively), serum transaminases levels (decreased by 51% and 27.2%, respectively), lipid profiles, uric acid concentrations, and liver stiffness measurements (decreased by 22.2% and 24.2%, respectively). Additionally, microbiome analysis showed increased diversity, improved anti-inflammatory and colonization resistance capacity, reduced pathogens, and enriched probiotics. A review of seven Chinese and international randomized controlled trials (RCTs) investigating the application of FMT in MAFLD was conducted. Among these, four trials reported improvement in liver function post-treatment. Two trials reported reductions in small intestinal or gastric permeability, one trial demonstrated a decrease in homeostasis model assessment of insulin resistance (HOMA-IR), one trial noted a reduction in blood lipid levels, and one trial documented a decrease in fat attenuation index (FAI). Only one trial included histological evaluation of liver tissue before and after FMT, which did not demonstrate significant pathological improvement. The combination of FMT and lifestyle intervention has achieved quite satisfactory therapeutic effects in the treatment of MAFLD, providing new ideas and potential therapeutic targets for the management of MAFLD. This approach holds broad application prospects. However, further confirmation through large-scale RCTs is still needed.

Type-2 diabetes mellitus (T2DM) is a chronic disorder marked by insulin resistance, beta (β)-cell dysfunction, and persistent hyperglycemia, often leading to diabetic kidney disease. There is growing recognition that inflammation exacerbates diabetes. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown promising immunomodulatory effects in the treatment of T2DM; however, the optimal dosing remains inconclusive.

Diabetes peripheral neuropathy (DPN) is closely related to the occurrence and development of sarcopenia. However, the relevant early biological metabolites and their pathophysiological mechanism is unclear.

Type 2 diabetes mellitus (T2DM) increases major adverse cardiovascular event (MACE) risk, requiring effective interventions. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce MACE, but the impact of baseline characteristics on their efficacy is unclear from previous analyses.

We aimed to evaluate the efficacy and safety of roflumilast compared to alpha-lipoic acid (ALA) in type 2 diabetic patients with diabetic neuropathy.

We aimed to investigate the association and causality between blood pressure (BP) during pregnancy and gestational diabetes mellitus (GDM).

Heart failure (HF) is a severe and common complication of type 2 diabetes mellitus (T2DM), associated with increased morbidity and mortality. Although the biomarker NT-proBNP, at a cut-off value of 125 pg/mL, has demonstrated satisfactory discriminatory power for predicting HF risk in T2DM patients, its measurement remains inaccessible in most primary healthcare settings in China. This study aimed to develop and externally validate a machine learning-based nomogram for predicting the risk of elevated NT-proBNP (≥125 pg/mL) as a surrogate for HF risk in patients with T2DM.

To investigate the correlation between α-glycosidase inhibitors (AGIs) and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).

Although body mass index (BMI) is an established risk factor for cardiovascular diseases (CVD), many studies found that obese patients with established CVD had better prognosis than their lean counterparts. The study aimed to investigate whether this inverse association between BMI and arterial stiffness can be explained by body composition analysis.

Diabetic nephropathy (DN) is a common chronic microvascular complication of diabetes mellitus (DM). Circular RNAs (circRNAs) have emerged as ideal biomarkers for various diseases. Recent studies have shown that circXPNPEP3 is upregulated in high glucose-induced human umbilical vein endothelial cells. In this study, we aimed to examine the expression levels of circXPNPEP3 in the serum of patients with DN and to evaluate its diagnostic potential for this condition.

In this study, we aimed to investigate the association between skeletal muscle area (SMA), subcutaneous fat area (SFA), and visceral fat area (VFA), quantified using computed tomography (CT), and the risk of type 2 diabetes mellitus (T2DM). We also evaluated the predictive performance of these parameters for assessing T2DM risk.

The global burden of diabetes mellitus (DM) and its complications is a major global public health challenge. This study aimed to improve community capacity for DM management by developing a risk prediction model for complications and providing health management recommendations using machine learning (ML).