To investigate the feasibility and effectiveness of an 8-week multimodal physical therapy program for adults with constipation.

In this study, we investigate clinical outcomes of inflammatory bowel disease (IBD) patients prescribed opioids after discharge from the hospital or emergency department (ED).

Infliximab (IFX) is commonly used in the management of acute severe ulcerative colitis (ASUC), yet up to 30% of individuals still require colectomy within 1 year. Clinical data characterizing these patients, however, are limited.

To compare the interobserver variability of the American Foregut Society (AFS) endoscopic classification of esophago-gastric junction (EGJ) integrity with the Hill classification among endoscopists with varying expertise, assessing reproducibility in real-world clinical settings.

Risk of Helicobacter pylori (H. pylori)-related gastroduodenal diseases is influenced by the degree of chronic gastritis, while other microbes reside in gastric mucosa may be relevant to this process. This study aimed to characterize the microbiome composition in the gastric mucosa, especially with an attempt to its correlation with histologic and serological degrees of H. pylori-related gastritis.

Heart rate variability (HRV) can detect the onset of inflammation in ulcerative colitis (UC), a condition in which fatigue is an often-overlooked symptom that significantly affects patients' quality of life. Here, the capability of a novel validated wearable vital signs patch measuring HRV to assess disease activity and fatigue severity was explored in UC patients.

Mucosal integrity testing (MI) is a diagnostic modality for gastroesophageal reflux disease (GERD). The aim of this study was to evaluate whether MI predicted long-term improvement in reflux symptoms and the ability to discontinue proton pump inhibitors (PPIs).

To compare clinical outcomes of terlipressin as continuous versus bolus infusion for the management of acute variceal hemorrhage.

Prolonged inhibition of gastric acid secretion may constitute a risk factor for colon polyps (CP) and colorectal cancer (CRC). We hypothesized that esophageal diseases treated with antisecretory medications may be associated with an increased frequency of CP and CRC.

To systematically evaluate the effects of mobile health (mHealth) technology interventions on body weight and liver enzyme levels in patients with nonalcoholic fatty liver disease (NAFLD).

Distinguishing between inflammatory and fibrotic strictures is crucial for guiding treatment strategies in Crohn's disease. This study aims to identify the optimal approach for differentiating intestinal strictures in Crohn's disease by combining endoscopic and radiologic examinations.

Perianal fistulizing Crohn's disease (PFCD) is known to impact patients' quality of life (QoL). However, the interactions between PFCD activity itself with patients' psychosocial well-being and social determinants of health (SDOH) are not fully understood.

Gastric peroral endoscopic myotomy (G-POEM) is an emerging endoscopic approach to treat refractory gastroparesis (GP). Previous studies have shown short-term benefits, but the long-term outcomes are unclear. This analysis evaluated the short- and long-term efficacy of G-POEM compared with standard medical treatment for adults with refractory GP.

Describe the establishment and expansion of a global gastrointestinal (GI) partnership and its impact on the advancement of GI care in Rwanda.

Definitively prove noninferiority of biosimilar infliximab to originator.

Adjunct agents in bowel preparation for colonoscopy have the potential to improve procedure outcomes. We performed a systematic review and meta-analysis to investigate the effects of adjunct single-dose linaclotide with bowel prep on colonoscopy outcomes.

To evaluate whether low-volume bowel preparation achieved similar rates of bowel cleansing as standard volume bowel preparations among hospitalized patients and assess the tolerability and safety of their use in this population.

The ideal resection strategy for rectal neoplasms extending to the dentate line (RNDLs) remains unclear. Transanal surgical approaches and endoscopic mucosal resection (EMR) have their limitations related to inadequate visualization, device maneuverability, and securing an adequate margin on the anal side. Endoscopic submucosal dissection (ESD) appears to overcome some of the limitations of transanal surgical and snare-based endoscopic techniques. Therefore, we evaluated the safety and efficacy of ESD for resection of distal rectal lesions within 2 cm of the dentate line.