Stress urinary incontinence (SUI) annoyed women worldwide and surgery remain importance for those who failed to observative managements.

Prostate deobstruction surgery effectively relieves lower urinary tract symptoms in men with benign prostatic obstruction, but some patients fail the initial trial without catheter (TWOC) postoperatively, requiring recatheterization. This study aimed to identify clinical and urodynamic predictors of initial TWOC failure following prostate deobstruction surgery.

Aquaporin-2 (AQP2) and vasopressin V1a receptor (AVP-V1a) are membrane proteins involved in water transport regulation in renal and extrarenal tissues. Their presence in the urinary bladder suggests a role in local water handling. This study aimed to investigate whether pelvic nerve stimulation induces translocation of AQP2 and AVP-V1a in the bladder urothelium of rats, thereby revealing a potential neural regulatory mechanism in water permeability.

Pelvic organ prolapse (POP) and overactive bladder (OAB) symptoms frequently coexist. Most patients with POP may present with at least one OAB symptom of any grade, and OAB symptoms can be alleviated by conservative or surgical treatments for POP. This study investigated data from patients with POP who underwent laparoscopic sacrocolpopexy (LSC) at our institution to determine the factors that led to the emergence of postoperative OAB symptoms or its improvement after LSC.

To investigate the long-term therapeutic satisfaction after augmentation enterocystoplasty (AE) or non-AE bladder therapy in patients with Hunner interstitial cystitis (HIC).

This study aimed to determine whether urinary secretory immunoglobulin A (sIgA) levels differ between patients with bladder pain syndrome/interstitial cystitis (BPS/IC) and healthy controls, and to assess whether urinary sIgA is linked to mucosal immune mechanisms that may contribute to BPS/IC pathophysiology.

This study aimed to measure the cumulative anticholinergic burden in older outpatients in South Korea with and without newly started overactive bladder (OAB) medications, and to assess the contribution OAB treatment-related antimuscarinics have on overall anticholinergic exposure.

Low bladder compliance (BC) poses a significant clinical challenge. Nevertheless, studies exploring pharmacological mechanisms to improve BC remain limited. We investigated the efficacy of a β3-adrenoceptor agonist, mirabegron, on BC in comparison with anticholinergics.

Parkinson disease (PD) is a common, progressive neurodegenerative disease, affecting approximately 1% of the population over 60. The associated morbidity and mortality are increasing at a faster rate than for any other neurological disorder. Lower urinary tract symptoms (LUTS) are reported in up to 85% of patients and can significantly impair quality of life (QoL). There are few studies to date that utilise the Montreal Cognitive Assessment (MoCA) to assess cognitive performance and compare this to motor symptoms and LUTS severity.

Overactive bladder (OAB) syndrome is a subset of storage lower urinary tract symptoms that significantly affects health-related quality of life, impacting social, occupational, and psychological well-being. Although the precise pathophysiology of OAB remains unclear, disruption of the neural network that regulates lower urinary tract activity has been suggested. The brain-bladder axis depends on a complex and extensive network of brain regions, with the periaqueductal gray (PAG) playing a pivotal role in mediating bidirectional communication.

Overactive bladder (OAB) substantially reduces quality of life (QoL), and novel implantable percutaneous tibial nerve stimulation (iPTNS) devices have emerged as promising alternatives to conventional management. This review provides a comprehensive comparative analysis of iPTNS devices for OAB, evaluating clinical outcomes, technical specifications, regulatory status, innovative features, and limitations-key aspects insufficiently addressed in prior studies. A narrative synthesis was conducted by reviewing clinical trials, technical reports, and regulatory documents related to 7 iPTNS devices. The analysis focused on improvements in health-related QoL (HRQoL), reductions in urgency urinary incontinence (UUI), device design variability, and regulatory distinctions. Our review revealed substantial differences among devices in terms of clinical efficacy (HRQoL and UUI reduction), technical design (including power sources and implantation methods), and regulatory status, with some devices approved by the U.S. Food and Drug Administration and others still under development. While iPTNS devices show considerable promise in OAB management, significant gaps remain regarding long-term outcomes and real-world adherence. Future innovations, particularly closed-loop neuromodulation, hold promise for improving efficacy and advancing personalized therapy.

This study investigated spontaneous locomotor activity and metabolic phenotype in animal models of autism spectrum disorder (ASD) and major depressive disorder (MDD), with a focus on motivation to engage in voluntary exercise.

Aging is associated with various physiological changes. These include microvascular dysfunction, which impairs cerebral blood flow and neuronal health, leading to cognitive impairment. Although exercise has demonstrated beneficial effects on aging, its specific impact on age-related microvascular dysfunction and blood-brain barrier (BBB) disruption requires further investigation. This study aimed to evaluate whether an 8-week treadmill exercise regimen in aged mice could improve cognitive impairment by alleviating microvascular and BBB damage and reducing neuroinflammation.

This study investigated whether the combined application of treadmill exercise and vitamin D injections exerts neuroprotective effects in nonpathological mice by enhancing cognitive function, regulating immune responses, preserving blood-brain barrier (BBB) integrity, and improving mitochondrial efficiency.

Perivascular adipose tissue (PVAT) dysfunction contributes to vascular impairment in obesity, primarily through altered lipid accumulation, inflammatory cytokine imbalance, and disrupted endothelial signaling. This study aimed to investigate whether aerobic exercise can ameliorate PVAT-induced vascular dysfunction in mice with obesity induced by a high-fat diet.

Angiotensin II (Ang II) is widely recognized as a primary factor in the development of hypertension; however, recent research also implicates it in skeletal muscle damage and atrophy. The precise mechanisms by which Ang II impacts muscle morphology and the molecular pathways related to atrophy remain unclear. Moreover, the potential protective effects of aerobic exercise against Ang II-induced muscle alterations have not been fully elucidated. This study aimed to investigate the effects of Ang II on skeletal muscle structure and atrophy-related molecular markers and to assess whether aerobic exercise can confer protective effects against these changes in an Ang II-induced animal model.

This study evaluates the efficacy of holmium laser enucleation of the prostate (HoLEP) as a deobstructive surgical intervention for patients with detrusor underactivity (DU) or an acontractile bladder (AcB).

We developed an innovative 2-stage procedure combining transurethral sphincterotomy (TURS) with artificial urinary sphincter (AUS) implantation to restore voiding in patients with refractory bladder emptying disorders. This proof-of-concept study evaluated its safety and efficacy.

Urodynamic testing, a minimally invasive procedure commonly performed in urology, often induces preprocedure anxiety due to its invasive nature and insufficient preparatory information. This study investigated whether supplementing traditional verbal and written explanations with video-animated information could help reduce anxiety in patients undergoing urodynamic testing.