Focal segmental glomerulosclerosis (FSGS), a clinicopathological condition characterized by nephrotic-range proteinuria and presenting microscopically as focal segmental sclerosis of the glomerulus, often progresses to end-stage renal disease. Patients with primary FSGS who undergo kidney transplantation often experience recurrence, leading to graft function loss and ultimately a shortened life span. However, the pathogenesis about post-transplant recurrence of FSGS remains unclear.

This study aimed to evaluate the guideline concordance of chronic kidney disease (CKD) testing among high-risk patients in a city in Northwest China and identify key factors influencing testing practices.

In clinical practice, we observed significant fluctuations in serum uric acid (SUA) levels among patients with hyperuricemia (HUA). However, few studies have explored whether SUA variability in HUA patients with chronic kidney disease (CKD) is associated with CKD progression, all-cause mortality, or cardiovascular mortality. To address this gap, we conducted a multicenter real-world study to investigate these potential associations.

The post-biopsy International IgA Nephropathy Prediction Tool (IIgAN-PT) models were updated to assess progression risk 1 or 2 years after biopsy. This study externally validated both models in a contemporary Asian cohort with extended follow-up to evaluate long-term predictive performance.

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, characterized by podocyte injury and impaired autophagy. Epitranscriptomic mechanisms, particularly N6-methyladenosine (m6A) RNA modifications, have emerged as critical regulators in kidney disease, but their role in autophagy regulation within podocytes remains poorly understood. The aim of this study was to investigate the role of the m6A demethylase FTO in regulating podocyte autophagy and the pathogenesis of diabetic kidney disease (DKD), with a focus on its downstream effector ATF3.

(L.) rhizome has been widely consumed as a spice and food-flavoring agent and in traditional medicines for the treatment of various diseases such as stomach pain, vomiting, diarrhea, infections, and renal disorders. The clinical use of gentamicin (Genta), an aminoglycoside antibiotic, is constrained due to nephrotoxicity. The existing investigation intended to estimate the mechanistic antioxidant, anti-inflammatory, and anti-apoptotic actions of galangal essential oil (Gal EO) against nephrotoxicity induced by Genta.

Renal anemia, a common complication of chronic kidney disease (CKD), is traditionally managed with erythropoiesis-stimulating agents (ESAs), which carry cardiovascular risks. Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, offers a novel mechanism by enhancing erythropoietin production and iron metabolism. While randomized controlled trials demonstrate its efficacy, real-world data on long-term safety and effectiveness remain limited.

Diabetic nephropathy (DN), a critical complication of diabetes, is characterized by progressive renal function impairment and fibrosis development. F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin ligase, is recognized for its role in metabolic disorders; however, its specific functions and mechanisms in DN remain incompletely understood. This study aimed to clarify the role of FBXW7 in the pathogenesis of DN.

Although the World Health Organization no longer classifies coronavirus disease 2019 (COVID-19) as a global health emergency, its long-term sequelae continue to affect survivors physically, psychologically, and socially.

Rituximab (RTX) is a key therapeutic agent for maintaining remission in steroid-dependent nephrotic syndrome and frequently relapsing nephrotic syndrome, demonstrating both efficacy and safety. However, reliable biomarkers for predicting relapse remain under investigation.

Endothelium-mediated regulation of vascular tone plays a crucial role in modulating vascular functions, especially in the kidney, a highly vascularized organ. Therapeutic interventions targeting this process, such as endothelin axis blockage, have demonstrated positive results across various kidney diseases. However, the long-term effects remain poorly explored. Mendelian randomization (MR) and Transcriptome-Wide Association Study (TWAS) provide an approach to investigate the lifelong effects of genetically determined variations in endothelial vasoactive pathways on renal outcomes, mimicking a naturally occurring randomized controlled trial.

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease and is increasingly recognized to involve early and progressive tubulointerstitial injury. However, the key molecular drivers of this process and their therapeutic potential remain poorly defined.

Kidney transplantation is the best modality of kidney replacement therapy for kidney failure, and yet global shortages of donor kidneys persist.

The growing threat of chronic kidney disease (CKD) to human health has gained considerable attention. But a comprehensive analysis of the CKD burden in China at both the national and provincial level has not been done. This study aimed to investigate the CKD burden by age, gender, CKD causes, and geographical region in China from 1990 to 2021.

The frequent co-occurrence of kidney and heart diseases stems from complex, bidirectional pathophysiological interactions, which contribute to elevated morbidity and mortality and present significant challenges in clinical management.

There is a close relationship between oxidative stress and renal ischemia-reperfusion injury (RIRI). Dihydroquercetin (DHQ, also known as Taxifolin) can reduce kidney damage, and suppress cellular damage caused by oxidative stress. This study aimed to investigated the effects and underlying mechanisms of DHQ on RIRI.

Weight gain and central obesity are common in peritoneal dialysis (PD) patients. In the general population, body roundness index (BRI) has been found to be a convenient anthropometric measurement for the assessment of central obesity and visceral adiposity. However, the role of BRI in PD patients has not been explored.

Crescentic lupus nephritis (cLN) is an uncommon and severe phenotype in LN with limited data on outcomes and relevant risk factors.

The progression evaluation of autosomal dominant polycystic kidney disease (ADPKD) is critical to the treatment strategy and prognosis prediction of the disease, but the current evaluation methods are time-consuming and costly.

Emerging evidence suggests a potential association between dyslipidemia and renal dysfunction. Remnant cholesterol, defined as the cholesterol content of triglyceride-rich lipoproteins, has not been thoroughly investigated in relation to rapid renal function decline in individuals with preserved kidney function. Therefore, our study aimed to clarify this association in a nationwide Chinese cohort.

Peritoneal fibrosis (PF) from long-term peritoneal dialysis (PD) is one of the main reasons for the ultrafiltration failure and the abandonment of PD in patients, and there is no effective treatment available. The dynamic changes in the PD microenvironment and their relationship to PD-related fibrosis remain unclear.