Osteoporosis and subsequent fractures not only seriously threaten the health of the aging but also escalate healthcare costs and social burdens. Undoubtedly, it is necessary to constantly optimize the diagnosis and treatment of osteoporotic fractures, and further understanding and investigation of the related studies is indispensable. However, the research on osteoporotic fractures is difficult to summarize, with complicated content and multiple disciplines involved. Consequently, this bibliometric analysis was conducted to gain a comprehensive understanding and grasp the hot topic of osteoporosis worldwide, which is beneficial to precisely guide research trends and demonstrate emerging treatments and preventive strategies.

Osteoporosis is a growing health burden requiring early risk assessment. In Saudi adults ≥ 60 years, FRAX scores with and without BMD showed minimal reclassification, with most shifts toward higher risk in younger groups. FRAX without BMD offers reliable stratification, supporting its use as a first-line screening tool.

This study examines the association between multimorbidity, fragility fractures, and the subsequent financial burden among older adults in India using nationwide data of 66,066 individuals. Seventy-one percent reported multimorbidity with fractures, higher costs in private care, and infirm integrated health strategies that target fall prevention, multimorbidity, and equal access to healthcare.

This study examined whether fatty liver increases the risk of osteoporosis. Over 12 years, people with nonalcoholic fatty liver disease had a significantly higher risk of developing osteoporosis. These findings highlight the importance of bone health monitoring in middle-aged adults with fatty liver.

Hip fractures in elderly pose signifcant healthcare challenges. Understanding the burden of disease associated with fall-related hip fractures will enable the implementation of measures for prevention and treatment in this vulnerable group.

Individuals with sarcopenia and osteoporosis often suffer from vertebral fractures. In this study, we show that sarcopenia (reduced muscle mass) is very common in patients with osteoporotic vertebral fractures and triples the risk of suffering from multiple vertebral fractures. Detection of sarcopenia may improve patient care in osteoporosis and prevent future fractures.

DXA densitometry is the current gold standard for the diagnosis of osteoporosis, but alternatives have been proposed.

This study used explainable AI to improve the Danish FREM model for predicting one-year risk of major osteoporotic fractures in over 2.4 million individuals aged ≥ 45. A DART boosting algorithm improved performance (AUC 0.77), with explainable outputs aiding clinical interpretation and guiding referrals for fracture risk assessment.

This study assessed osteoporosis risk factors in Armenian women using the FRAX calculator. A BMI below 30, corticosteroid use, prior fractures, thyroid disorders, and diabetes significantly increased fracture risk. Findings highlight the need for national osteoporosis guidelines tailored to Armenia.

This study examined whether bisphosphonate treatment can reduce fragility fractures in patients with osteoporosis in Jordan. We found significantly fewer fractures and better quality of life in treated patients, supporting the importance of early treatment in routine care settings.

In alignment with previous studies using the densitometric vertebral fracture assessment tool, the prevalence of radiographic moderate-severe vertebral fractures in rural postmenopausal women was 34%. FRAXplus could bring one additional woman to treatment intervention thresholds who may have otherwise been missed had additional risk factors not been captured.

W2TPD, a twice-weekly teriparatide administration regimen, was used on 163 patients. The continuation rate was 47%, with only one new fracture. Even after performing antiresorptive therapy, spine BMD increased significantly in the majority of groups. W2TPD demonstrated good efficacy and tolerability in a real-world sequential osteoporosis treatment model.

Over 14 years, hip fracture patients grew older, with shorter hospital stays. Femoral neck fractures were more common than intertrochanteric fractures, but the latter had worse functional outcomes and higher complications. Surgery was standard, with nailing for intertrochanteric and arthroplasty for femoral neck fractures. Older age increased adverse outcomes.

Hip fracture poses a major public health burden in aging populations. The relationship between long-term air pollution exposure and hip fracture risk remains unclear. In our study, long-term exposure to PM, PM, and NO was associated with increased hip fracture risk, while ozone exposure showed a protective effect.

In 744 adults from Pune (Western India) and nearby villages, osteoporosis prevalence was higher in rural women than urban (43% vs 18%). Advancing age, location, height, tobacco use and sunlight were key determinants. These findings emphasize urgent need for preventive and management strategies in rural population to reduce osteoporosis burden.

T-scores alone are inadequate for identifying hip fracture risk. Incorporating FRAX-HFP scores and femoral strength improves risk assessment. Tailored interventions are needed for different ethnicities, with a focus on females due to higher fracture risk. Sex-specific thresholds and targeted prevention strategies are essential for effective fracture prevention.

Hip fracture data were retrieved from the Iraqi government's Ministry of Health and the Kurdistan region's Ministry of Health for the years 2022-2023 and used to create a FRAX® model to facilitate fracture risk assessment. Hip fracture rates and probabilities were compared with estimates from neighboring countries.

Using nationwide data from 2006 to 2022, we found that vertebral fracture rates in Korea plateaued recently, with a slight decline during COVID-19, while one-year mortality remained unchanged. These findings highlight the growing burden of osteoporotic fractures and underscore the need for targeted prevention and management strategies.

Healthcare claims and survey data are increasingly used to assess the osteoporosis burden, but agreement and comparative validity of derived indicators are poorly documented. We show that no single data source can estimate the osteoporosis burden. Instead, coupling data sources allows assessing its burden and associated treatment and knowledge gaps.

Anti-osteoporosis medications (AOM) play a crucial role in the management of osteoporosis. The utilization of AOM in Iran has shown an overall increasing trend over time, albeit with fluctuations. However, underutilization is a fundamental challenge. Alendronate has consistently been the most widely used medication.