Stapokibart (CM310), a humanized anti-IL-4Rα monoclonal antibody, blocks IL-4/IL-13 signaling for type 2 inflammatory diseases like seasonal allergic rhinitis (SAR), where standard of care often fails.

Congenital choanal atresia (CA) is a rare malformation that can present as a neonatal emergency or with delayed symptoms in older children. Despite advances in endoscopic transnasal repair, recurrence and restenosis remain major challenges, and evidence from resource-limited countries is scarce. This study reports a 12-year experience managing CA in Syria, highlighting clinical characteristics, surgical outcomes, and prognostic factors for recurrence.

The oncologic benefit of adjuvant radiotherapy (aRT) and the impact of facial nerve sacrifice have not been examined for early-stage low- and intermediate-grade salivary gland carcinomas (LIG-SGCs) with isolated perineural invasion (PNI) and no other adverse features.

Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic vasculitis frequently involving both upper and lower airways, commonly associated with severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). Although anti-IL-5/IL-5R biologics such as mepolizumab and benralizumab are established therapies for maintaining systemic remission, a subset of patients continues to experience refractory sinonasal symptoms. We report two EGPA cases with well-controlled systemic disease under anti-IL-5/IL-5R therapy but persistent uncontrolled CRSwNP, who were treated with add-on dupilumab. Both patients demonstrated substantial improvement in sinonasal outcomes, as reflected by reductions in SNOT-22 and nasal polyp scores, alongside maintenance of systemic remission (BVAS = 0). These findings highlight the potential role of dual biologic therapy targeting distinct inflammatory pathways in selected EGPA patients with refractory CRSwNP. Careful patient selection and close multidisciplinary monitoring are essential to ensure safety and optimize efficacy. Further studies are warranted to confirm long-term effectiveness and safety profiles.

First branchial cleft cysts (FBCCs) are rare developmental anomalies that typically present in childhood. We report a unique case of a Type I FBCC in a 43-year-old male whose only symptom was isolated facial pain without infection or mass. Imaging and biopsies were inconclusive, prompting surgical excision for definitive diagnosis and symptomatic relief. Histopathology confirmed a branchial cleft anomaly. This case highlights the importance of including congenital anomalies in the differential diagnosis for atypical facial pain even in the adult population and underscores the value of a thorough and multi-disciplinary diagnostic workup.

Treatment of head and neck cancers is based on many schemes, and in the case of radiochemotherapy, the main side effect impacting a patient's quality of life is hypoacusis. Its prevention and analysis are consequently essential.

To evaluate quality-of-life (QoL) in patients undergoing extracapsular dissection or partial superficial parotidectomy for benign parotid disease.

To address rising opioid prescriptions, more institutions have implemented prescribing guidelines emphasizing non-opioid and other multimodal pain control. In April 2021, the AAO-HNS released guidelines for common otolaryngologic procedures to improve patient safety, reduce unnecessary opioid use, and lower the risk of postsurgical opioid dependence. The goal of this study is to evaluate the trends in opioid and non-opioid prescribing for septoplasty in relation to the publication of a major clinical practice guideline by the AAO-HNS in April 2021.

Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of immunosuppression in solid organ transplant patients. Tonsillar hypertrophy commonly results from PTLD, and tonsillectomy is usually performed when PTLD is the suspected cause. Risk factors for PTLD-mediated tonsillar hypertrophy remain poorly defined. This study aimed to identify clinical and therapeutic factors associated with tonsillar hypertrophy following PTLD diagnosis.

To evaluate, in Obstructive sleep apnea (OSA) patients, the use of pre-treatment drug-induced sleep endoscopy (DISE) as a patient selection tool, that could improve the outcomes of mandibular advancement device (MAD) therapy. A multicenter retrospective case-control study has been performed.

To design and implement a deep learning-based multimodal data fusion classification model that integrates laryngoscope images and voice signals to improve the diagnostic accuracy of laryngeal diseases, enabling rapid and precise identification for clinical support.

Thyroid nodules initially classified as Bethesda categories II, III, or IV are occasionally re-aspirated due to evolving clinical or ultrasonographic features, or as part of structured protocols. This real-world study aimed to (1) determine the frequency of changes in Bethesda classification following repeat fine-needle aspiration (FNA), (2) assess the relationship between Bethesda category shifts and the clinical indication for re-aspiration, and (3) evaluate malignancy rates in nodules that demonstrated cytologic reclassification.

To investigate how visual cues influence speech recognition in Mandarin-speaking cochlear implant (CI) users and examine age-related differences in audiovisual (AV) integration across varying sound intensities and noise conditions.

Oncocytic lipoadenomas represent a rare, benign variant of salivary gland tumors (SGT). The parotid gland is the most common location for these tumors, accounting for 85 % of cases, followed by the submandibular gland. There have only been 7 reported cases of submandibular gland oncocytic lipoadenomas documented to date.

Burnout is prevalent in the medical field, including within Otolaryngology - Head and Neck Surgery. To date, no study has focused on the impact burnout plays on the future career choices of otolaryngology residents and fellows. Additionally, this study aimed to assess how perceptions of burnout among subspecialty teaching faculty impacted trainees' future career choices.

To analyze national trends in the prevalence of office-based transnasal esophagoscopy (TNE) procedures and compare with traditional operating room-based procedures utilizing transoral flexible and rigid esophagoscopy.

The apparent diffusion coefficient (ADC), obtained from diffusion-weighted imaging (DWI) on MRI, quantifies water diffusion within tissues and is commonly used to distinguish benign from malignant tumors. In the sinonasal region, preoperative diagnosis is often challenging due to diverse histologies and limited biopsy samples. This study aimed to assess the utility of ADCmean values in categorizing sinonasal tumors into benign tumors (excluding papillomas), papillomas, and malignant tumors, and to evaluate their potential as a supplementary diagnostic tool.

Nasal bleeding, especially following nasal or sinus surgery, significantly impacts patient recovery. Traditional hemostatic methods no longer meet the clinical needs of patients. With the advancement of treatment options for nasal bleeding, absorbable hemostatic materials, known for their excellent biocompatibility and degradability, have garnered widespread attention in the field of nasal hemostasis. This article aims to review the recent progress in research on hemostatic materials for nasal bleeding and post-operative nasal surgery. It analyzes the mechanisms of action of various types of hemostatic materials, including collagen-based, cellulose-based, alginate-based, and platelet-rich plasma (PRP) materials, discussing their clinical applications, advantages, and limitations. Finally, the article explores the future direction of nasal hemostatic materials, particularly the innovative development of bioactive absorbable materials and their potential applications in nasal bleeding. Overall, with the continuous emergence of novel materials, nasal hemostatic materials are expected to play an increasingly vital role in improving therapeutic outcomes, reducing recurrence, and enhancing the quality of life for patients.

To assess the efficacy, safety, and tolerance of drainage under local anesthesia compared to immediate tonsillectomy to treat uncomplicated unilateral peritonsillar abscess (PTA) in adults.

Vestibular schwannomas (VS) are benign tumors that can cause hearing loss, tinnitus and balance disorders. Radiosurgery and open surgery remain the primary treatments, but predicting hearing preservation post-surgery remains challenging due to a variety of factors. Machine learning (ML) has emerged as a promising tool for predicting hearing outcomes in VS patients. This meta-analysis aims to systematically evaluate the diagnostic accuracy of ML models in predicting hearing preservation in VS patients undergoing surgery.