This study aims to explore the clinical efficacy of transarterial chemoembolization (TACE) combined with the immune checkpoint inhibitor nivolumab administered via hepatic arterial infusion (HAI) in inhibiting tumor angiogenesis in hepatocellular carcinoma (HCC).

The high incidence of breast cancer combined with the growing number of innovative and complex treatment options, such as oral tumor therapies, is increasingly shifting oncological care to the outpatient sector. This development is placing substantial capacity burdens on office-based providers. Evidence suggests that the use of "treatment navigators" - qualified nonphysician personnel tasked with coordination and support - can improve efficiency and reduce workload for physicians. This study aimed to assess the economic effects of task delegation in the German outpatient breast cancer from the healthcare provider´s perspective.

The goal of our study was to generate a standardized assessment of postoperative complications and functional results in patients undergoing salvage lymph node dissection (sLND) in a multimodal setting with prior primary therapy and possibly multiple courses of radiation due to nodal-recurrent prostate cancer.

Myeloid-derived suppressor cells (MDSCs) constitute a heterogeneous population that plays a key role in tumor-related immune suppression. MDSCs are immature cells that express the myeloid markers CD11b and Gr1 in mice and accumulate in tumor-bearing mice, including those with HER2/neu+ breast cancer. We previously reported that tumor regression by anti-neu antibodies requires both innate and adaptive immunity. MDSCs inhibit both types of immunity and are immunosuppressive, particularly for T cells. However, the effect of anti-neu antibodies on MDSCs remains unclear.

Precise prediction of pathological complete response (pCR) following neoadjuvant chemoradiotherapy (nCRT) in rectal cancer may identify candidates for non-operative management. The optimal selection of diagnostic tools is, therefore, of major clinical importance.

Ovarian cancer is a prevalent and highly lethal gynaecological cancer. Among its various subtypes, epithelial ovarian cancer predominates, comprising ten distinct subtypes and contributing significantly to the overall burden of ovarian malignancies. Concurrently, endometriosis, characterized by the ectopic growth of endometrial tissue within the pelvis, affects a substantial number of women of reproductive age.

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is associated with poor prognosis in advanced stages. This study aims to develop a prognostic model for patients with ccRCC based on a lysosome-related gene signature.

Advanced stages of prostate cancer (PCa), in particular metastatic castration-resistant prostate cancer, are associated with significant morbidity and mortality. The androgen receptor (AR) signaling pathway is a cornerstone of therapeutic intervention, but resistance mechanisms and disease progression demand increasingly complex treatment strategies.

Maintenance of subjective well-being and health-related quality of life (HRQoL) play a crucial role in the treatment of metastatic cancer. The metronomic chemotherapy (MCT) may be a favorable treatment option in metastatic breast cancer (MBC) and platinum-resistant recurrent ovarian cancer (ROC). The aim of this study was to evaluate the HRQoL of MBC and ROC patients treated with MCT.

Specialist palliative care (SPC) is rarely integrated into the management of patients with an allogeneic hematopoietic stem-cell transplantation, despite considerable symptom burden and mortality. We aimed to assess hematologists' and nurses' views on SPC integration.

Ovarian cancer (OC) accounts for the most cancer deaths in women worldwide, despite it being the 8th most common one. Almost two-thirds or OC cases present in advanced stages (III/IV) and will require maintenance therapy lasting for up to 36 months in some patients. Despite the introduction of innovative treatments, OC recurs in about 80% of cases in advanced stage disease. Management of recurrent OC is based on multiple factors and includes either surgery, in suitable candidates, followed by chemotherapy or systemic treatment alone. Due to its heavy physical, psychological and economic burden, reducing mortality of OC through prevention and early diagnosis is of utmost importance.

Brain metastases are a common risk in non-small cell lung cancer (NSCLC) patients. Generally, brain metastases are associated with reduced survival rates, and brain imaging is recommended during tumour staging. Here, we assess the incidence and survival among patients with non-curative advanced NSCLC (aNSCLC) with brain metastases, as well as the use and timing of brain imaging based on German claims data.

This study aimed to investigate the predictive effect of peripheral blood inflammatory indexes on total pathologic complete response (tpCR) in patients with breast cancer receiving neoadjuvant systemic therapy (NST).

With 1:280 carriers, Lynch syndrome (LS) is the most prevalent tumor predisposition syndrome and the most important cause for hereditary colorectal cancer (CRC). Tumors from affected individuals usually present with a deficient expression of mismatch repair (MMR) proteins leading to a high microsatellite instability (MSI).