Previous studies have identified visual perception and functional impairments in individuals with schizophrenia, particularly in areas such as contour integration and contrast sensitivity. These deficits can significantly impact daily functioning and social interactions. This study aims to investigate the impact of a visual remediation intervention (VRI) on visual perception deficits, specifically contour integration and contrast sensitivity, while also assessing its effects on social cognition, visual attention, and disease symptoms.

Insomnia has a significant impact on metabolic changes and cognitive impairments in schizophrenia (SCZ) patients. This study aimed to explore these relationships in SCZ patients.

The purpose of this study was to investigate the relationship between emotional difficulties and auditory processing.

This study aims to investigate the stress and death anxiety levels of individuals who experienced the earthquake after the major earthquakes that occurred in the Pazarcık and Elbistan districts of Kahramanmaraş in Turkey on February 6, 2023.

The aim of the study was to estimate the prevalence of hallucinations in patients with AD and to assess its associated clinic-demographic and neuropsychiatric profile. Three hundred and eighty-one patients collected within the National Institute of Mental Health Genetics Initiative were included. Characteristics of hallucinators and non-hallucinators were compared by logistic regression. One hundred sixty-nine (44.4%) patients were hallucinators. Hallucinators presented a more severe AD than non-hallucinators with a lower MMSE (10.6 ± 8.9 versus 14.6 ± 8.9; OR 0.9; 95%CI 0.92-0.97; -value < 0.001) and a higher CDRS (2.7 ± 1.0 versus 2.4 ± 1.1; OR 1.2; 95%CI 1.01-1.44; -value 0.035). Hallucinators presented a more severe neuropsychological profile, characterised by apathy, verbal and physical aggressivity, and wandering. Hallucinations may represent a clinically useful tool for identifying patients who may require more intensive interventions.

To evaluate the effects of different management strategies (watchful waiting, dose reduction, switching and adjunctive treatments) on prolactin levels and clinical outcomes in patients with antipsychotic-induced hyperprolactinaemia.

Benign prostatic hyperplasia (BPH) commonly affects ageing men, with unclear long-term psychiatric effects. We examined these associations using cross-sectional, longitudinal and genetic data from the UK Biobank.

To inform clinical decision-making for patients with obesity, binge eating disorder (BED) and bipolar disorder (BD), we compared individuals with BED and those without BED who participated in a randomised controlled trial (RCT) of liraglutide for weight loss in stable BD with obesity.

Prolactin elevation is a common adverse effect of antipsychotic medications. The study aimed to explore the potential of metformin in managing olanzapine-induced hyperprolactinaemia.

The Yale Global Tic Severity Scale (YGTSS), although extensively utilised in China for evaluating tic disorders (TD), relies exclusively on clinician-administered assessments. At present, no parent-report instruments validated in the Chinese context are available for assessing tics. The Parent Tic Questionnaire (PTQ), originally developed as the first parent-rated tool for TD symptom evaluation, has yet to undergo validation in any Asian language.

Non-suicidal self-injury (NSSI) is a strong predictor of increased future suicidal ideation and risk. The highest prevalence of NSSI is in adolescents. NSSI is performed as a maladaptive response to emotion regulation distress when facing an intense negative emotional load. One of the physiological markers of Emotion Dysregulation (ED) can be measured quantitatively through changes in Heart Rate Variability (HRV).

Antipsychotic drugs are used in the treatment of many mental disorders, especially psychotic disorders, bipolar disorders and neurodevelopmental disorders in children and adolescents. Antipsychotics, along with their effectiveness in treatment, have also been associated with a number of adverse effects. One of these is hyperprolactinaemia (hyperPRL) that occurs with antipsychotics. This situation is thought to be due to dopamine blockade in the tuberoinfundibular pathway, which has an effect on prolactin release. Hereby, we present a 15 year old female adolescent bipolar disorder type 1 case who developed hyperprolactinaemia with risperidone treatment which was ameliorated with metformin use (850-2000 mg/day). Although there are studies showing that metformin can be used in the treatment of hyperprolactinaemia, as far as we know, there are not enough studies on the use of metformin in adolescents. Future studies are needed to elucidate the risk factors, aetiological mechanism and treatment alternatives of this adverse effect, which occurs due to antipsychotics and may negatively affect medication compliance.

This study aimed to compare interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and inflammatory markers from the complete blood count in drug-free male schizophrenia (SCZ) patients during acute exacerbation with healthy controls and to evaluate changes after treatment.

To examine the relationship between depressive symptoms and daily functioning among patients with bipolar depression using the Montgomery-Åsberg Depression Rating Scale (MADRS) and Sheehan Disability Scale (SDS).

Clinical decision-making for the pharmacological treatment of aggressive behaviour in psychiatry remains challenging. Asenapine, a second-generation antipsychotic with a higher affinity for dopamine D4 than for D2 receptors, may become a treatment option, although this remains to be demonstrated.

Understanding real-life management of mental health disorders is crucial for enabling effective social and healthcare interventions. This retrospective real-world study investigated differences in the management of young adults (<30 years) and adults (≥30 years) starting treatment with second-generation antipsychotics (SGAs) in Italy, Spain and Poland.

The perceived stress scale (PSS-10) assumes that stress results from perceived situational demands exceeding the perceived coping resources. However, today's hectic lifestyles may lead to stress even when demands can be met. We aimed to assess a new measure of stress, the D-Stress scale, which focuses on feelings of relentless pressure, irrespective of the coping resources.

Psoriasis is a chronic inflammatory, autoaggressive disease. It is known that psychiatric comorbidity in psoriasis contributes to the progression and exacerbation of the disease. This study aims to examine psychiatric disorders and personality traits in a sample of patients with psoriasis.

The triazolopyridine derivative trazodone is approved for the treatment of major depressive disorder (MDD) in adults; according to the available literature, this molecule, through a specific dose-dependent profile of action, was found to be a potential therapeutic option in some neurological conditions. This systematic review aimed to synthesise the available evidence on the use of trazodone in neurological patients.

This meta-analysis compares intermittent theta burst stimulation (iTBS) and repetitive transcranial magnetic stimulation (rTMS) in treating schizophrenia, focusing on efficacy and safety.

Electroconvulsive therapy (ECT) has long been considered the main method of treatment for patients with resistant major depressive disorder (MDD). Recent studies have shown that ketamine infusion can also effectively improve treatment-resistant MDD. Thus, we conducted this meta-analysis to compare the efficacy of ketamine with ECT for treating treatment-resistant depression.