This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy, such as Cerebrolysin, is likely to further improve patient outcomes. Beyond its established neurorecovery benefits, recent data indicate that Cerebrolysin also offers protection to the neurovascular unit and the blood-brain barrier. This paper introduces the CErebrolysin in RECanalization And Perfusion (CERECAP) program, a collaborative initiative of independent academic investigations exploring the favorable trends of Cerebrolysin in reperfusion. The CERECAP program has generated compelling data demonstrating Cerebrolysin's alignment with current AIS reperfusion therapy concepts, particularly its role in early intervention targeting multiple pathways. We review these studies and discuss the critical need to clearly define the patient population that benefit most from adjunctive Cerebrolysin therapy in AIS.

Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for myocardial infarction and stroke. Elevated Lp(a) >50 mg/dL (>125 nmol/L) is common and present in about 1 in 5 individuals. Although Lp(a) may be a cause of young ischemic stroke (age ≤60), limited data on national testing trends in this population are available, testing in the general population remains low overall, and different organizations have varying guidelines for testing. By determining the degree to which this population is tested, information on national testing trends of Lp(a) in young ischemic stroke patients may influence future guideline recommendations to increase Lp(a) testing. This study aims to use a large, real-world dataset to assess trends of Lp(a) testing in young ischemic stroke patients in the United States from 2015-2024.

For stroke patients with history of possible Direct Acting Oral Anticoagulant use, clinicians must make treatment decisions without knowledge of whether the patient is therapeutically anticoagulated. A urine-based point-of-care test might help guide these emergency decisions.

Stroke remains a significant health concern in high-income countries (HICs) and is increasing among younger adults. Although largely preventable, public awareness of stroke risk factors in HICs is not well established. We assessed awareness levels in World Bank-classified HICs and identified associated factors.

Subarachnoid hemorrhage (SAH) is a severe cerebrovascular event often associated with high mortality and significant neurological impairment. Neuroinflammation is a hallmark of early brain injury (EBI), which substantially determines clinical outcomes. Interleukin-33 (IL-33) is a cytokine within the IL-1 family, known to regulate inflammatory and immune reactions through binding to its specific receptor, suppression of tumorigenicity 2 (ST2). This study focuses on clarifying how IL-33/ST2 signaling participates in the pathophysiological process following SAH in male mice..

No prior study has investigated the potential of the cholesterol, high-density lipoprotein, and glucose (CHG) index as a predictor of clinical outcomes in patients with acute ischemic stroke (AIS) undergoing endovascular treatment (EVT). This study aimed to assess the effect of the CHG index on functional prognosis and build a better predictive model.

Perioperative stroke is a devastating surgical complication associated with high mortality rates. The goals of our study were to identify the predictors of postoperative stroke and to explore the possible role of intraoperative hypotension (IOH).

The association between age at natural menopause and cerebrovascular risk is unclear. This study investigates non-linear relationships, effect modification, mediation, and long-term stroke-free survival in postmenopausal women.

To systematically analyze the application effect of holistic nursing intervention based on Harmonious Nursing Theory in patients during stroke recovery period, and provide evidence-based basis for optimizing clinical nursing programs.

The modified Rankin Scale (mRS) is the most common measure of post-stroke functional outcome. However, its impact on post-stroke care is limited by its subjectivity, impracticality in vulnerable populations, and susceptibility to cultural and language barriers. Artificial intelligence (AI) applied to triaxial wrist-worn accelerometry data may offer an objective way to characterize post-stroke functional status and related changes.

Post-stroke depression (PSD) is a serious complication affecting the survival and functional recovery of stroke patients, with a prevalence of approximately 30 %. It predominantly occurs within the first year after stroke, particularly within the first three months. Although individual lifestyle factors are associated with PSD, the combined impact of composite lifestyle factors (smoking, alcohol consumption, physical activity, diet, sleep, and obesity) on PSD remains unclear. This study aims to examine the association between composite healthy lifestyle behaviors and PSD among stroke survivors in the United States.

Deep medullary veins (DMVs) play important roles within the cerebrovascular network related to brain drainage and clearance. Although they have been previously correlated with brain volume, it is unknown whether their count is specifically correlated with subcortical or cortical volume changes.

The Improving Cerebral Blood Flow and Cognitive Function in Patients with Asymptomatic Intracranial/Carotid Stenosis with Nattokinase (ICC-PACS) trial was a single-center, double-blind, placebo-controlled study, aiming to evaluate the effects of 6-month nattokinase (NK) supplementation on cognitive function in patients with asymptomatic intracranial/carotid artery stenosis.

This study evaluated the efficacy and safety of acupuncture or moxibustion combined with rehabilitation therapy for post-stroke shoulder-hand syndrome (SHS).

To explore the association between remnant cholesterol (RC) and intracranial and extracranial vascular in-stent restenosis (ISR).

Microcirculatory changes contribute to delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH), but bedside assessment remains challenging. Sidestream darkfield imaging (SDF) enables direct visualization but may be difficult in critically ill patients. The objective was to evaluate the feasibility of repeated sublingual and conjunctival SDF imaging in aSAH patients and to compare microcirculatory changes at both sites.

Reversible cerebral vasoconstriction syndrome (RCVS) is a rare cause of thunderclap headache, often triggered by environmental or pharmacologic stressors.

While obesity is a recognized stroke risk factor, traditional measures like body mass index (BMI) have limitations in assessing body fat distribution. Novel central obesity indices-including waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CI), a body shape index (ABSI), and weight-adjusted waist index (WWI)-offer accessible alternatives reflecting visceral fat. However, previous studies have often focused on single-time obesity measurements, neglecting how changes over time and their cumulative effects influence stroke risk.

Edaravone dexborneol (ED) is a novel cytoprotective drug for treating acute ischemic stroke (AIS) with synergistic antioxidant and anti-inflammatory effects. This study aimed to assess the efficacy and safety of ED in acute large vessel occlusion (LVO) patients with successful recanalization after endovascular treatment (EVT).

This study aims to investigate the effects of the Robotic Hand Exoskeleton system on spasticity, motor control skills, activities of daily living, quality of life, and functional independence in stroke patients.

The hypoperfusion intensity ratio (HIR), derived from CT perfusion (CTP), reflects collateral flow quality, but its optimal formulation remains unsettled.