Tumor necrosis factor-alpha (TNF-α) inhibitors, including infliximab, have redefined the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis (UC). Despite their efficacy, these agents are associated with rare but serious adverse events, including drug-induced interstitial lung disease (D-ILD). We report a case of infliximab-induced ILD in a 63-year-old male undergoing treatment for UC. The patient presented with fever, dyspnea, and a miliary hypersensitivity pattern on imaging. Infectious causes were excluded, and drug-induced pulmonary toxicity was diagnosed. Discontinuation of infliximab and appropriate management led to gradual clinical improvement. This case highlights the importance of early recognition and management of pulmonary complications associated with TNF-α inhibitors. Given that UC itself and other autoimmune diseases can predispose patients to ILD, we also explore the role of disease activity and additional risk factors, including prior exposure to 5-aminosalicylic acid-based medications. Endoscopic disease activity, fecal calprotectin levels, autoimmune markers (ANA, ENA, ANCA), and bronchoalveolar lavage results are provided to further elucidate the diagnostic process.

This study aimed to evaluate the demographic, clinical, and procedural characteristics of adult patients presenting to the emergency department (ED) due to gastrointestinal foreign body ingestion (FBI).

Nonceliac wheat sensitivity (NCWS) is characterized by gastrointestinal and extraintestinal symptoms triggered by gluten ingestion. Its symptomatology overlaps substantially with irritable bowel syndrome (IBS) and functional dyspepsia (FD), leading to diagnostic challenges. Data on the prevalence and predictors of NCWS among patients with IBS or FD, especially those with refractory symptoms, are limited. We aimed to determine the prevalence, clinical predictors, and impact of a gluten-free diet (GFD) in this population using the Salerno Experts' Criteria.

Given the high rate of recurrence in Crohn's disease (CD), postoperative maintenance therapy is crucial for preventing disease recurrence. However, the relationship between infliximab trough levels and postoperative endoscopic recurrence in CD patients has been insufficiently evaluated.

Esophageal hypervigilance and symptom-specific anxiety are emerging as key factors influencing symptom severity in patients with dysphagia and gastro-esophageal reflux disease (GERD). We aimed to evaluate the relative contributions of esophageal hypervigilance, alongside parameters of high-resolution manometry (HRM) and pH study, to esophageal symptom severity.

Irritable bowel syndrome with constipation (IBS-C) is a common gastrointestinal disorder that significantly impacts quality of life. Tenapanor, a sodium/hydrogen exchanger inhibitor, shows promise in managing IBS-C. This systematic review and meta-analysis aim to evaluate the efficacy and safety of tenapanor 50 mg compared with placebo.

Nonalcoholic fatty liver disease (NAFLD) is linked to colorectal cancer and adenoma. Lean NAFLD is associated with a higher colorectal cancer risk than non-lean NAFLD. NAFLD was modified as metabolic dysfunction-associated steatotic liver disease (MASLD). Certain adenoma features carry a high risk of metachronous lesions requiring early colonoscopy follow-up. The association between MASLD, lean MASLD, and colorectal adenomas with these features is unclear and is assessed in this study.

Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a growing global health challenge. This study evaluates the global burden of MASLD-related liver diseases-including MASLD with cirrhosis (MASLD-C) and liver cancer due to metabolic dysfunction-associated steatohepatitis (LC-MASH) from 1990 to 2021, with projections to 2045.

For poorly differentiated early gastric cancer (PDEGC), the oncologic safety and outcomes of endoscopic resection vs. surgical resection remain controversial. This study aimed to evaluate the prognostic difference of endoscopic resection and surgical resection for PDEGCs.

To identify the rate and predictors of successful antitumor necrosis factor (TNF) dose deescalation in patients with inflammatory bowel disease (IBD).

Mild-moderate ulcerative colitis (UC) in clinical trials has been defined as an adapted Mayo Clinic score ≥4 with a Mayo endoscopic score (MES) of 2 and rectal bleeding score ≥1. This study aims to explore whether UC patients with lower endoscopic burden but active histology have similar outcomes to those with 'conventional' mild-moderate UC.

VE202 is an oral, defined 16-strain bacterial consortium with properties that may diminish dysbiosis and alleviate symptoms of inflammatory bowel disease. This phase 1 study evaluated VE202 safety and tolerability and assessed strain colonization.

The onset of acute diverticulitis (AD) is a significant concern, yet the optimal preventive strategy is unclear.

Acute variceal bleeding (AVB) comprises 70% of upper gastrointestinal bleeding in cirrhotic individuals, with first-episode mortality of 15-20%. A third of surviving patients rebleed within 6 weeks of initial presentation. Scores such as Child-Turcotte-Pugh (CTP), model for end-stage liver disease-sodium (MELD-Na), and complete Rockall score (CRS) predict such outcomes, but with limitations. The platelet-albumin-bilirubin (PALBI) score is an attractive, rapid scoring system for predicting 6-week adverse outcomes after AVB.

The aims of the present study were to assess the histological evolution of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) using paired liver biopsies, identify the factors associated with fibrosis and clinical disease progression, and determine the relationship between histological progression and clinical outcomes.

Nonalcoholic fatty liver disease (NAFLD), which affects approximately 25% of the global adult population, is a metabolic-associated hepatic disorder characterized by the interplay between inflammation and metabolism. Although evidence linking inflammatory factors and plasma metabolites to NAFLD progression, their causal relationships and mediating mechanisms remain unclear.

Alarm symptoms at coeliac disease (CeD) diagnosis predict a more severe disease presentation, but the long-term implications remain unclear. We studied the prevalence of alarm symptoms at diagnosis and their association with outcomes.

Current guidelines for hepatocellular carcinoma (HCC) lack standardized adjuvant therapy recommendations, particularly for patients with high-risk of recurrence after curative resection. This multicenter retrospective study aimed to evaluate the efficacy and safety of adjuvant sintilimab (a programmed death protein-1 inhibitor) in this underserved population.

Despite a rising prevalence of eosinophilic esophagitis (EoE), real-world data on current management challenges remain limited.