The lipid accumulation product (LAP) is a sex-specific index that reflects visceral adiposity and lipid imbalance. This study aimed to investigate the prospective association between LAP and cardiometabolic multimorbidity (CMM), and to assess its value in risk prediction.

This study aimed to examine the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiac structure and cardiorenal function in older adults with hypertension and pre-heart failure.

Left ventricular (LV) ejection fraction (LVEF) and LV end-diastolic diameter (LVEDd) are well-established predictors of adverse cardiovascular events. However, the possible association with survival in patients with infective endocarditis (IE) treated with aortic valve replacement (AVR) is underexplored. Additionally, it is important to investigate whether sex modifies these associations.

We aim to review the published references regarding cardiac lead perforation subsequent to pacemaker implantation. This study evaluated the risk factors, clinical presentations, and management strategies of patients with perforated cardiac lead after pacemaker implantation.

Secondary tricuspid regurgitation (STR) is increasingly prevalent in heart failure (HF) patients and independently predicts adverse outcomes. This retrospective study aimed to stratify severe STR patients based on right ventricular fractional area change (RVFAC) and elucidate echocardiographic parameters influencing prognosis.

Bedaquiline improves treatment outcomes in drug-resistant tuberculosis (DR-TB), but prolongs the QT interval; the cardiac safety must be thoroughly evaluated in clinical applications.

Atrial fibrillation (AF) is the most common arrhythmia among patients undergoing transcatheter aortic valve replacement (TAVR). Post-TAVR permanent pacemaker implantation (PPI) predictors for patients in sinus rhythm were studied. However, scarce data is available about patients with AF. The aim of the study is to assess the prevalence of AF among patient undergoing TAVR, to identify predictors of PPI, and to study the association between PPI and long-term mortality.

The aim of this study was to examine the causal relationship between blood pressure and digestive tract cancers in European and Asian populations using Mendelian randomization (MR).

Evidence on dual- and triple-targeted therapy in patients with left-to-right shunt congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH) remains limited. We compared the efficacy of triple- versus dual-targeted drug therapy in patients with CHD-PAH and evaluated treatment outcomes and prognosis.

Transcatheter aortic valve implantation (TAVI) may be complicated by postoperative bleeding due to heparin use. Heparin antagonists, such as protamine, have shown potential in reducing bleeding risks. This meta-analysis assesses the efficacy and safety of protamine in reducing bleeding complications after TAVI.

Graves' disease is associated with cardiovascular alterations. Data on the left ventricular (LV) function and left atrial (LA) mechanics in Graves' disease remain limited. This study investigated the relationship between disease duration and myocardial deformation parameters, including LA strain and LV global longitudinal strain (LV-GLS).

Early myocardial injury during chemotherapy may precede declines in left ventricular ejection fraction. We assessed the diagnostic accuracy of cardiac troponin I (cTnI) for early detection of cancer therapy-related cardiac dysfunction (CTRCD).

Introduction Guideline-directed medical therapy (GDMT) optimization and effective de-congestion are known to improve outcomes in admitted heart failure (HF) patients, yet their implementation is suboptimal. Using a HF decision aid and point-of-care ultrasound (POCUS) at admission, this resident-led quality improvement (QI) initiative aimed to improve GDMT use and reduce HF readmissions. Methods This prospective, single-center QI initiative compared resident-performed POCUS and HF decision-aid use (the QI arm) with routine hospital care in admitted HF patients. Assignment to the QI arm was based on availability of residents trained to perform POCUS on admission. Primary outcome: 30-day hospital readmission; secondary outcomes: GDMT utilization using a standard score, adverse outcome occurrence, and 30-day mortality. Results The study was terminated early due to funding constraints. We enrolled 103 (42 in the QI arm) out of planned 254 patients. At discharge, the QI arm had a trend towards improvement in GDMT scores (+21±23% vs +12±24% in controls, p=0.106), in particular, a numerically higher proportion of patients in the QI arm were discharged on renin-angiotensin-aldosterone blockers (70.4% vs 51.4% of controls, p=.126). Adverse effect occurrence and 30-day outcomes (readmissions and mortality) were not significantly different between groups. Significantly more people in the QI arm had a transthoracic echocardiogram in the hospital (26 (65.0%) vs control: 21 (38.9%), p=.012). Conclusion This study showed that a resident-led QI initiative was feasible and resulted in modest improvement in GDMT use and echocardiography utilization but without effectively altering 30-day outcomes.

Brain tumors may disrupt cardiac autonomic regulation, leading to arrhythmias that complicate patient management. This review aims to synthesize evidence on the relationship between brain tumor characteristics, treatments, and cardiac arrhythmias.

Conventional echocardiography does not identify abnormal cardiac function for heart failure with preserved ejection fraction (HFpEF) in patients with uremia. This study aimed to investigate the diagnostic value of three-dimensional speckle-tracking imaging (3D-STI) for HFpEF in uremia patients.

Vericiguat has been shown to improve clinical outcomes in patients with heart failure (HF) with reduced ejection fraction in several randomized controlled trials. However, there is limited real-world evidence regarding its effectiveness in clinical practice outside of the controlled research setting.