The author has identified an error in the department of the authors in the article titled "Highly Efficient Bimetallic Catalyst for the Synthesis of N-substituted Decahydroacridine-1,8-diones and Xanthene-1,8-diones: Evaluation of their Biological Activity" published in Current Organic Synthesis, 2024, 21(3) [1]. Details of the error and a correction are provided here. ORIGINAL 1. SANDEEP T. ATKORE Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India 2. PRANITA V. RAITHAK Department of Clinical Biochemistry, Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India CORRECTED 1. SANDEEP T. ATKORE Department of Biochemistry, Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India 2. PRANITA V. RAITHAK Department of Botany, Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India We regret the error and apologize to readers. The original article can be found online at: https://www.benthamscience.com/article/136681.

A direct synthesis of functionalized dimethyl fumarate derivatives of 2- (2-((E)-(2-oxoindolin-3-ylidene)methyl)-1H-benzo[d]imidazol-1-yl) is achieved via one-pot reaction involving 2-methyl-1H-benzo[d]imidazole and appropriate isatin in the presence of DMAD.

Unsaturated pyrazolones can participate in organocatalytic reactions with various substrates to form spiro-cyclic pyrazolones, and fuzed-pyrazolone heterocycles. The present review describes progress since 2013 in the organocatalysis transformations of unsaturated pyrazolones. Pyrazolones are prevalent structural motifs in a wide variety of natural products and drug or drug-like molecules. A series of nitrogen-containing pyrazolones exhibits anticancer, antimicrobial, anti-inflammatory, anticonvulsant, antidepressant, antidiabetic, and antipyretic activities. Especially, chiral spiro-cyclic pyrazolones are recognized as targets in natural products and clinical pharmaceuticals. Organocatalytic systems are powerful and reliable approaches that allow us to build structurally complex molecules in an enantioselectively and diastereoselectively manner. Avoiding the use of transition metal catalysts, readily available bifunctional organocatalysts, and the performance of the reaction at ambient temperature are other advantages of these catalytic systems. Despite considerable progress in this field, it is still one of the challenging goals for chemists to make new biologically active heterocyclic molecules.

Palladium-catalyzed carbonylative cross-coupling reactions with various carbon monoxide (CO) sources cultivate competent routes for the synthesis of bulk and value-added chemicals. However, the practical use of this odorless, inflammable, lethal gas has always raised a concern for chemists. The attention and advancement of various CO-surrogates is surely welcomed as a green alternative to CO-gas. However, the main concern lies in the suitability and scalability of these CO-surrogate-driven reactions. Literature showed the progress of various ways to make CO from these CO surrogates. One of the most convenient sources is using metal carbonyls which are already known to lose CO easily. Among all the kinds, Mo(CO)6 gained much popularity but its toxic nature and demand for high temperatures restricted its use. However, Co(CO) is popular as a catalyst but as an CO-source reports are scarce. This low-melting CO-releaser was found effective in flourishing aminocarbonylation, alkoxycarbonylation, and reductive carbonylation under mild conditions. This mini-review portrays the recent developments of palladium-catalyzed carbonylation reactions using Co(CO) as a CO source.

Thiadiazoles exhibit a variety of biological activities, including antimicrobial, antiviral, antituberculosis, carbonic anhydrase inhibitor, antitrypanosomal agent, and anticonvulsant properties.

Ripasudil hydrochloride or 4-Fluoro-5-{[(2S)-2-Methyl-1,4- diazepan-1-yl] sulfonyl isoquinoline hydrochloride known as K-115 is used for the treatment of glaucoma and ocular hypertension. In the API industry, to achieve and ensure the quality of drug substances, there is a need for impurity identification, synthesis, and characterization. The impurities are formed during the process, either side reaction or degradation or carried over from the starting material.

An efficient method for synthesizing cyclic arylsulfonium salts has been developed by selective aryl transfer to the sulfur atom from aryl(mesityl)iodonium triflates, a recyclable series of diaryliodonium salts.

Given the inadequacies of current chemotherapy, there is a need for more effective anticancer agents. Imidazole and thiazole compounds have demonstrated significant biological activity, making them promising candidates.

Sodalite is a type of zeolite with an intricate structure comprising a system of interrelated cages and tunnels. It is extensively used in sieving applications due to its unique structure and properties. As a result, it finds several uses in water and air purification, radioactive decontamination, detergents, and so on. Due to the potential positive environmental impact of sodalite materials, analysing the molecule at a structural level becomes the need of the hour.

Hydrazonoyl halides and methylhydrazinecarbodithioate have been generally utilized in the synthesis of heterocycles.

Derivatives of pyrimidinone, dihydropyrimidinone, and 2,4-diaryl-substituted pyrimidines were synthesized by cyclocondensation of α-aminoamidines with various saturated carbonyl derivatives and their analogs. The therapeutic potential of the newly synthesized derivatives for cancer treatment was evaluated using molecular docking calculations. The molecular docking results indicate that some of the synthesized diaryl derivatives of pyrimidine exhibit high binding affinity towards PIK3γ.

The protection of the hydroxyl group as formamides is a crucial initial step in pharmaceutical synthesis.

1,4-Dihydropyridines (1,4-DHPs) are highly versatile and bioactive compounds known for their pharmacological properties, including cardiovascular, anticancer, and antioxidant activities. Traditional synthesis methods often involve harsh conditions, such as high temperatures, toxic reagents, and lengthy reaction times, leading to poor yields and environmental concerns. Consequently, there has been a growing focus on developing more sustainable, efficient, and eco-friendly alternatives for their synthesis. Among these, the catalytic one-pot multicomponent reaction (MCR) method has emerged as a promising strategy, offering high efficiency. Catalysts play a crucial role in enhancing reaction efficiency and selectivity, with various systems-metal-based, organocatalysts, polymer-supported catalysts, and enzymatic catalysts-each offering unique advantages. Metal catalysts provide high reactivity and selectivity, organocatalysts are more environmentally benign, polymer-supported catalysts offer improved stability and sustainability, and enzymatic catalysts enable highly specific reactions under mild conditions. However, challenges such as catalyst cost, reusability, scalability, and substrate scope remain. This review examines catalytic strategies for 1,4-DHPs synthesis from 2016 to 2024, highlighting reaction conditions, substrates, and yields. The analysis aims to inspire further exploration of new catalytic methods, expanding the application of 1,4-DHPs in medicinal chemistry.

This study includes synthesis, characterizations, antimicrobial, antioxidant, and docking molecular study of novel Bis-Azetidinone compounds that combined two units of β-lactam rings .In the present investigation, the aromatic aldehydes with primary amine were condensed to create Schiff's base, which was then reacted with chloroacetylchloride to produce bis-Azetidinone compounds.

Bitter melon L.) is a member of the Cucurbitaceae, which is also known as bitter squash, bitter gourd, karela, Goya melon and balsam pear. It is a rich source of different vitamins, potassium, zinc and other nutrients. The main pharmaceutical benefits of bitter melon are "antiinflammatory", "antioxidant activity", "antimicrobial characteristic", "anticancer activity", and "antihelmintic activity", "antidiabetic effects", "antiinflammation activity" and "treat skin conditions". Its fruit is the main part of the plant which has been used for medicinal and food purposes. The primary metabolites in bitter gourd are common sugars, chlorophyll and proteins while secondary metabolites are carotenoids, alkaloids, phenolics, curcubitane triterpenoids, saponins, etc. The present review aims to study and survey on the nearly up-to-date results and findings regarding the pharmaceutical advantages and health benefits of bitter melon in an organic life.

Hybrid inorganic/organic nanoparticles are used to make nanocomposites. These nanocomposites combine the different properties of the organic polymer and the inorganic nanoparticles, which improves the overall system properties.

The current review aimed to provide an understanding of the preparation, reactions, and biological action of thiazoles. The purpose of this review was to focus on the progress made in the synthesis of physiologically effective thiazole products with their interactions. A combinatorial approach was proposed, and extensive attempts were made in the search for thiazoles by chemists in many domains due to the information of multiple artificial pathways and variable physics-chemical factors of thiazoles. In this regard, the biological activities linked to thiazole and the processes used in its production were thoroughly discussed in this study. The research period covered in this review was from 1905 to 2024, providing a useful and convenient strategy for the synthesis of numerous thiazole derivatives. Moreover, research on such reactions is still ongoing and undoubtedly will provide new fused functionalized compounds of both industrial and biological interests. A literature survey revealed that a great deal of interest has been focused on the synthesis and reaction of thiazoles due to their wide range of biological activities. Remarkable insights into different synthetic paths and modified physical-chemical features of such thiazoles would be helpful for chemists worldwide.

The reaction between 4-hydroxy-3,5-dimethoxyenzaldehyde and 2-nitroaniline has been discovered, and the final product has been identified such as 2-6-dimethoxy- 4-((2-nitrophenylimin)methyl)phenol (C1).

The biopolymer chitosan, which is derived from chitin, has shown great promise for tissue regeneration and regulated drug delivery. Its broad-spectrum antibacterial action, low toxicity, biocompatibility, and many other attributes make it appealing for use in biomedical applications. Crucially, chitosan may be synthesized into a range of forms that can be customized to provide desired results, such as hydrogels, membranes, scaffolds, and nanoparticles. Hydrogels that are biocompatible and self-healing are innovative soft materials with considerable potential for use in biomedical applications. Hydrogels that self-heal using chitosan, which are mostly made by dynamic imine linkages, have gained a lot of interest because of their great biocompatibility, moderate preparation requirements, and capacity to mend themselves in a physiological setting. In this study, a summary of the applications of chitosan-based self-healing hydrogels in bone, cartilage, and tooth tissue regeneration and drug delivery is provided. Lastly, we have mentioned the difficulties and potential outcomes for the biomedical field's creation of hydrogels based on chitosan that can mend themselves.

Allelopathy related to a positive or negative impacts on one type of plant, by a chemical produced by another type of plant such as weeds, and different kinds of chemicals are hydroxamic acids, phenolics, and short-chain fatty acids. The potential allelopathic impacts of weeds is directly associated to the plan species used, as well as to the concentration of the aqueous extract available in the environment.

This research introduces an eco-friendly, one-pot multicomponent synthesis of pyrimidopyrimidines (4a-4i) and amino-1,3-dimethylpyrimidines (5a-5d) in an aqueous medium, utilizing citric acid as a catalyst.