Firefighters experience chronic occupational stress due to frequent trauma exposure and shift work, which contributes to stress-related symptoms such as sleep disturbance and somatic complaints. Despite a few neuroimaging studies in this population, white matter (WM) integrity and its clinical implications remain insufficiently understood. We investigated WM microstructural alterations in firefighters and explored their associations with occupational stress and related symptoms.

Sleep disorders are potential risk factors for Alzheimer's disease (AD), but their genetic association and shared gene mechanisms remain unclear. This study investigate the genetic correlation between AD and four sleep disorders phenotypes, and examined AD-sleep shared pathways in major depressive disorder (MDD) to assess a broader neuropsychiatric implication.

The relationship between frailty and depressive symptoms in older adults remains unclear, particularly regarding its nonlinear associations. We investigated whether baseline frailty index (FI) predicts incident depressive symptoms in study cohorts from China and the United States.

Yearning is hallmark of grief and prolonged grief disorder, but its psychological underpinnings are poorly understood. We aimed to address this by building on the phenomenological similarities with craving and investigating the role of desire thinking, a voluntary cognitive process central to activating craving.

Psychological resilience，an individual's capacity to adaptively cope with adversity, effectively buffers against depression. This study employed functional Near-Infrared spectroscopy (fNIRS) during an Autobiographical Memory Test (AMT) to investigate prefrontal and temporal cortical hemodynamic differences in university students stratified by resilience levels and their mechanistic impact on depression.

Self-reported executive function reflects perceived cognitive capacity in everyday executive processes and has been linked to various critical outcomes during adolescence, a period marked by heightened vulnerability to loneliness. However, few studies have examined the associations between loneliness and self-reported executive functions in adolescents. Whether subjective sleep quality statistically mediated the association also remains underexplored.

Depression among older women with cardiometabolic-based chronic disease (CMBCD) is influenced by both biological mechanisms but complex social and environmental determinants.

Discrimination is increasingly recognized as a key risk factor for student mental health. However, few longitudinal studies have assessed its association with clinically defined depression using standardized diagnostic tools. This study examines whether self-reported experiences of discrimination are associated with an increased risk of major depressive episode (MDE) one year later among higher education students.

Individuals with major depressive disorder (MDD) typically present subclinical symptoms even during remission. Evidence from the Dual Continua Model (DCM), the recent view of mental health as a dynamic balance condition, and the emphasis on the role of internal and external challenges and resources in sustaining or hindering mental health suggest that the joint investigation of positive mental health (PMH) and mental illness among persons with MDD in remission provides a comprehensive assessment of both lingering symptomatology and daily functioning. Through this integrated framework the time-budget and associated experience of persons with MDD in remission were investigated.

Maternal adverse childhood experiences (ACEs) are risk factors for increased mental health difficulties. However, intergenerational transmission mechanisms between maternal ACEs and adolescent behavioral difficulties are poorly understood. This study examined the mediating effects of maternal controlling parenting and youth-perceived mother-child attachment on the association between maternal ACEs and adolescent internalizing and externalizing behaviors.

Increased mental health-related outpatient visits among adolescents have been reported worldwide.

Experiences of gender identity invalidation (henceforth invalidation) occur when others do not to accept one's gender identity as "real" or "valid," and can be understood as a unique minority stressor, one that we conceptualize as a distinct form of enacted stigma (discrimination). We examine the association of invalidation with other minority stressors - internalized stigma (shame) and felt stigma (expectations of rejection) - and suicide risk (ideation and attempts in the past year). Cross-sectional data are drawn from a large and diverse sample of trans and nonbinary (TNB) individuals (N = 303) surveyed in New York City, the San Francisco Bay Area, and Greater Atlanta to present a preliminary examination of how experiences of invalidation may be associated with other minority stressors and suicide risk. We propose a path analytical framework for theorizing about these relationships. A series of paths within a structural equation model, which are adjusted for sociodemographic factors (sex assigned at birth, nonbinary gender identity, race/ethnicity, education, age, and income) and a more general measure of discrimination, suggest that invalidation experiences are directly associated with feelings of shame, expectations of rejection, and past-year suicide attempts. In addition, these analyses suggest that invalidation experiences are indirectly associated with past-year suicide ideation, through their association with expectations of rejection. These cross-sectional findings suggest that invalidation, which is largely unexamined in existing research, merits greater attention as a particularly pernicious minority stressor that may directly and indirectly increase suicide risk in gender minority populations.

Adolescent major depressive disorder (MDD) has become a growing public health concern, with rising prevalence over the past decade and significant impacts on social, academic, and occupational functioning. However, diagnosing adolescent MDD is hindered by limited specialist access and time-consuming gold-standard interviews. Therefore, it is imperative to develop an adolescent MDD detection system to provide auxiliary diagnosis and facilitate accurate clinical assessment by physicians.

Adolescent depression represents a significant public health challenge worldwide. While adverse life events (ALEs) are established predictors of depressive symptom, the mediating role of sleep quality remain underexplored in multi-ethnic contexts like Xinjiang, China.

Ketamine provides rapid acting symptom relief, making it a promising intervention for post-traumatic stress disorder (PTSD). However, the mechanisms driving its long-term efficacy over weeks and months remain poorly understood. This study investigated the short- and sustained impacts on gene expression of an open-label six-week subanesthetic oral ketamine trial in 23 PTSD participants (9 males, 14 females). Peripheral blood mononuclear cells (PBMCs) were collected at baseline, one week (short-term), and four weeks (sustained) post ketamine treatment for RNA sequencing and transcriptome analysis. Differential expression analysis identified substantial and persistent transcriptomic changes over time, with 533 genes upregulated and 621 downregulated across timepoints. Notably, there was a 37 % increase in differential gene expression between the short- and sustained responses, accompanied by a 6.5-fold rise in expression magnitude and an 8.8-fold enhancement in pathway activity. Pathway analysis emphasised important immune and inflammatory pathways that appear to be modulated by ketamine, including interferon alpha/beta signalling (z = 4), IL-17 signalling pathway (z = 3.36), and cytokine storm signalling (z = 4.26) and neutrophil degranulation (z = 6.0) which differed across timepoints. The findings suggest a transition from short-term inflammation suppression to sustained immune regulation. Changes in key cytokines, chemokines, interferons and antimicrobial peptides included, IL-6, IL-1β, IFI27, IL-10 signalling, CXCL8, SOCS1/3 and CAMP which represent central regulators of immune and inflammatory pathways. These molecular changes offer novel insights into the sustained therapeutic potential of ketamine for PTSD and highlight avenues for precision psychiatry and maintenance therapy to prevent relapse.

Bipolar disorder (BD) and major depressive disorder (MDD) impose a significant burden worldwide. Misdiagnosis between BD and MDD has long been a challenging issue. Frontal alpha asymmetry (FAA) is one of the most widely studied electroencephalogram (EEG) markers in mental health research. This study utilizes a relatively large sample size to investigate whether FAA can effectively differentiate BD from MDD.

Avoidance and family accommodation are common in pediatric obsessive-compulsive disorder (OCD). While family accommodation has received considerable investigation, avoidance in pediatric OCD has been comparatively understudied. Despite this, avoidance can mask overall symptom severity, hinder accurate diagnosis, and impede treatment effectiveness. This study characterized avoidance behaviors and their clinical correlates in 101 treatment-seeking children and adolescents (54% male; ages 7 to 17) diagnosed with OCD. Avoidance was measured using the Children's Yale-Brown Obsessive Compulsive Scale-II (CY-BOCS-II), and both youth self- and parent-report were used to assess depression, anxiety, family accommodation, and functional impairment. Avoidance behaviors were highly prevalent, with 76% of participants endorsing avoidance in at least one domain. Youth with avoidance demonstrated significantly higher OCD symptom severity, greater self-reported mood symptoms, increased family accommodation, and more functional impairment. Preliminary mediation analyses highlight that avoidance has a significant indirect effect on the relationship between OCD symptom severity and parent-reported functional impairment. Findings underscore the importance of assessing avoidance in youth with OCD to accurately capture its impact on functional impairment and guide targeted intervention.

To investigate the associations of sleep behaviors with the risk of schizophrenia, and explore the interplay between genetic and sleep patterns in the development of schizophrenia.

No clinically useful biomarkers currently predict antidepressant response to ketamine in treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD). This study investigated whether baseline thyroid-stimulating hormone (TSH) levels are associated with ketamine's antidepressant, anti-anhedonic, and anti-suicidal effects.

The association between childhood adversity and all-cause mortality risk as well as cardio-cerebrovascular disease mortality risk, and whether this differs by sex, remain unknown.

Excessive daytime sleepiness (EDS) is common in youth with major depressive disorder (MDD), and it may have some serious consequences, such as suicidal behavior. However, little is known about the pathways linking EDS to suicidal behavior in this population.

Persons with depression are differentially affected by metabolic alterations, notably, insulin resistance and dyslipidemia. Metabolic alterations affect acute pharmacotherapy response and predispose risk for cardiovascular diseases. We aimed to extend knowledge pertaining to the depression-metabolic alteration association by evaluating whether depressive symptom severity moderates the association.

Depression and sleep are associated to irritable bowel syndrome (IBS), but their relationship with broader functional gastrointestinal disorders (FGIDs, which include IBS, dyspepsia, and functional intestinal disorders) remains unclear. We examined depression, sleep, and FGIDs risk, exploring sleep's mediating role.

The aim of this research is to investigate how adverse childhood experiences (ACEs), specifically threatening (TrACEs) and depriving (DrACEs) ACEs, are linked to social isolation through a cohort study design, and to analyze how cumulative average sensory impairment plays a role in mediating this connection.

Major depressive disorder (MDD), as a common mental disorder, has been one of the leading causes of disability worldwide for the past thirty years. It involves synaptic dysfunction, yet molecular mechanisms remain elusive, and more suitable animal models are needed for research. Necl1 (Nectin-like molecule 1), a adhesion molecule predominantly expressed within the nervous system, plays a key role in the regulation of synaptic formation and function. However, it is still unclear whether NECL1 is involved in the occurrence of MDD.

Extensive evidence indicates that lifestyle and air pollution levels are strongly associated with psychiatric disorders. However, few studies in this field have integrated these two factors to examine their relationship with psychiatric disorders.

Depression is a global mental health crisis, exacerbated by stigma that hinders open expression, particularly in collectivistic cultures. While linguistic markers of depression (e.g., self-focus, negative emotions) have been identified in clinical, Western contexts, their replication in non-clinical, everyday online discourse and their intersections with self-stigma remain underexplored.

Endoplasmic Reticulum (ER) stress is implicated in Alzheimer's disease (AD) development. This study aims to identify ER stress-related genes associated with AD risk.

Chronic stress impacts brain function and emotion regulation, increasing depression risk. How chronic stress shapes neural dynamics in response to acute stress remains unclear. This study investigates how chronic stress influences neural responses after acute stress, focusing on ventromedial prefrontal cortex (vmPFC)-amygdala and vmPFC-hippocampus functional connectivity (FC) and their relationship to depression symptoms.

Social isolation has emerged as an increasingly critical public health issue among adolescents with depression. This study aimed to identify latent subgroups of social isolation based on its manifestations among adolescent patients with depression and to explore the associated influencing factors.