The management of trigeminal neuralgia secondary to multiple sclerosis (MS-TN) remains clinically challenging due to its refractory course and aggressive symptom pattern. Among available interventions, stereotactic radiosurgery (SRS) has emerged as a minimally invasive and effective option. This systematic review and meta-analysis aims to assess the efficacy and safety of SRS in patients with MS-related trigeminal neuralgia.

Depression is highly prevalent among patients with degenerative cervical spine disease and has been linked to worse postoperative outcomes across various surgical procedures. Prior studies in anterior cervical discectomy and fusion (ACDF) have primarily focused on limited endpoints such as pain or discharge disposition and were conducted before the COVID-19 pandemic. Given the rise in depression prevalence and its multidimensional impact on functional recovery, resilience, and quality of life in the post-pandemic population, a more comprehensive evaluation of its influence on ACDF outcomes is warranted.

Neuroanatomy is a cornerstone of medical education, yet is perceived by many as daunting. Student-led events, such as the National Undergraduate Neuroanatomy Competition (NUNC), newly re-established in Scotland, provides a platform to address this challenge by fostering academic interest and enhancing learning through extracurricular achievement and specialty talks.

The rising interest in global neurosurgery (GNS) is reflected in the apparent rise in related research output. This study aims to examine bibliometric trends related to the research subdiscipline of GNS within three leading neurosurgery journals, Journal of Neurosurgery (JNS), Neurosurgery, and World Neurosurgery.

This study is a single-center, retrospective cohort analysis of patients who underwent anterior cervical discectomy and fusion (ACDF) at Lanzhou University Second Hospital between January 2021 and April 2025. Patients were stratified according to the number of fusion levels (single-level, two-level, and ≥ three-level) and grouped based on the presence or absence of a drain. Perioperative variables, laboratory markers, radiological measurements, clinical scores, length of hospitalization, and associated costs were compared (P < 0.05).

Microsurgical clipping (SC) and endovascular coiling (EC) are both utilized in the management of ruptured intracranial aneurysms in pediatric patients presenting with non-traumatic aneurysmal subarachnoid hemorrhage (SAH). Data regarding the comparative safety of these techniques is limited. In this study, we aimed to evaluate the clinical outcomes of SC versus EC in pediatric patients presenting with non-traumatic SAH.

Patients who undergo resection of an intracranial tumor face significant deficits in cognitive function due to mass effect and treatment sequelae. However, there has been little investigation of what can be done to alleviate deficits and improve quality of life. This manuscript aims to explore evidence for the use of cognitive rehabilitation in patients undergoing resection of intracranial tumors.

Ticagrelor use is increasing in acute ischemic stroke and transient ischemic attack management, but optimal dosing is unclear. We aimed to compare the effectiveness and safety of reduced-dose ticagrelor (45/60 mg BID), full-dose ticagrelor (90 mg BID), and clopidogrel (75 mg daily) for secondary stroke prevention.

Cerebral edema (CE) is a common complication of acute large vessel occlusion ischemic stroke (AIS-LVO). Stress-induced hyperglycemia may exacerbate brain damage, leading to adverse outcomes. Our study investigated the association between stress-induced hyperglycemia and CE after bridging therapy and achieved successful reperfusion (modified Thrombolysis in Cerebral Infarction [mTICI] score 2b-3) in AIS-LVO patients.

Brain tumors, particularly malignant types, are associated with high mortality despite advances in multimodal treatment. The prognostic nutritional index (PNI) has been identified as a predictor of outcomes in various diseases. Despite these advances, prior investigations have predominantly targeted malignant brain tumors, leaving prognostic utility of PNI across the full spectrum of brain neoplasms largely unexplored. This study performed to evaluate the association between preoperative PNI and overall survival in patients undergoing brain tumor resection, including both benign and malignant tumors.

The aim of this study is to examine the psychological coping mechanisms of family caregivers of patients with stroke in the context of the perioperative period. Within the theoretical framework of Bounded Rationality Theory, we sought to delineate emotional responses, identify support needs, and inform the development of stage-specific, targeted psychological interventions.

Acromegaly, almost always caused by growth-hormone (GH)-secreting pituitary adenomas (PAs), leads to significant morbidity and mortality when left untreated. Surgical resection is the gold standard treatment, but biochemical remission following surgery occurs in only 40-60% of patients. We aimed to investigate characteristics of and outcomes in a large cohort of patients who underwent surgery for treatment of acromegaly from a GH-secreting tumor.

The original paravertebral foramen screw (PVFS) technique is safe; however, it is limited by its short screw length, which can potentially reduce biomechanical stability. We developed a modified PVFS (mPVFS) technique with a caudally shifted entry point, which enables the insertion of longer screws for greater stability. This study aimed to evaluate the feasibility, safety, and efficacy of modified PVFS (mPVFS).

Surgery for spinal chordomas is often extensive and carry a risk for complications. This study seeks to analyze factors contributing to prolonged length of stay (LOS) and 30-day readmission following spinal chordoma resection, utilizing data from the National Cancer Database (NCDB).

Nonfunctioning Pituitary Neuroendocrine Tumors (NFPitNETs) account for 14 %-54 % of all pituitary tumors and 10-15 % of primary intracranial tumors. Unlike functioning pituitary tumors, NFPitNETs are not associated with hormonal hypersecretion but can cause symptoms due to mass effects. These tumors may extend into critical areas, especially into the cavernous sinus, presenting surgical challenges. Subtotal resection, therefore, may occur and potentially lead to regrowth in 10 %-20 % of cases. This systematic review and meta-analysis aims to assess the safety and efficacy of surgical approaches for management of NFPitNETs classified as KNOSP grades 3 and 4, where significant or definite cavernous sinus invasion complicates surgical resection.

The clinical characteristics, disability, and comorbidities of migraine are not well characterized in the elderly, especially in comparison with the young. We aimed to study the headache characteristics, treatment profile, disability, and pattern of comorbidities in the elderly patients with migraine and compare these with those of younger patients with migraine to see if migraine in the elderly differs significantly from that in the young.

Mediterranean diet adherence is cross-sectionally associated with better mental health and quality of life (QoL) in people living with multiple sclerosis (plwMS), but prospective associations warrant further investigation.

Intraoperative confocal laser endomicroscopy (CLE) offers neurosurgeons a real-time, high-resolution imaging tool to differentiate tumor tissue from normal brain parenchyma during brain tumor resection. This study aims to evaluate the feasibility of incorporating CLE into the routine workflow of brain tumor surgeries.

Microsurgical treatment of middle cerebral artery (MCA) aneurysms continues to offer high obliteration rates with acceptable risks, despite an increasing preference for endovascular treatment methods. Yet, the risk of treatment-related ischemia, both symptomatic and radiological, remains a concern. We aimed to externally validate a recently proposed preoperative grading system for predicting risk of ischemic complications after microsurgical treatment of intracranial aneurysms.

Glioblastoma (GBM) is relatively radioresistant compared to other malignancies. Like other tumours undergoing radiotherapy, there is a variable response in similar patients having identical treatments.