Expert Review of Pharmacoeconomics & Outcomes Research

Present challenges impacting the management of psychological symptoms in patients receiving CAR-T therapy or stem cell transplantation
Feng A, Gottam M, Santivasi WL and LeBlanc TW
Hematopoietic stem cell (HSCT) and chimeric antigen receptor T-cell (CAR-T) therapy are crucial in the treatment of hematologic malignancies. While HSCT has been long established as a mainstay of the treatment of these diseases, CAR-T is a newer therapy with the potential to change the treatment landscape. Both cellular therapies are time and resource intensive, which has put stressors on patients that are unique from those associated with other forms of oncologic treatment.
Digital decision aids and prenatal outcomes: a systematic review and meta-analysis
Bratches RWR, Stockdill ML, Love A, Munoz EG, Smith T and Shorten A
Digitally delivered patient decision aids are becoming more prevalent to support prenatal decision-making. However, the effect of digital decision aids on prenatal outcomes is unclear. The objective of this systematic review and meta-analysis is to synthesize the currently available evidence on the effect of digital decision aids on prenatal outcomes, and quantitatively analyze the effect of interventions on prenatal outcomes across studies.
Individual vs societal perspectives: implications on quantitative benefit-risk assessment of vaccination
Kitano T, Salmon DA, Dudley MZ, Saldanha IJ, Levy JF, Austin JM, Thompson DA and Engineer L
The benefits and risks of each vaccine must be compared prior to their recommendation and again when new evidence emerges.
The health production model and the crucial role of health promotion
Annemans L, Aeyels D, Bejjani G, Briganti G, Broeckx D, Devisch I, Verdonck P, Simoens S and
Negating the burden of hip fracture in high-risk populations: a narrative review of epidemiology, costs, and multifaceted mitigation strategies
Liu E and Liu RY
Hip fractures represent a major global health burden, associated with substantial morbidity, mortality, and economic costs, particularly among older adults. With population aging accelerating worldwide, understanding of the epidemiology, cost drivers, and cost-effectiveness of prevention and management strategies is essential for informed resource allocation.
Economics perspectives on understanding antimicrobial use and resistance: a scoping review from theory to practice
Iskandar K, Roques C, Salameh P, Rizk R, Daham J, Hiligsmann M, Karam R and Molinier L
Antimicrobial resistance (AMR) is a complex global health challenge with significant, yet underutilized economic dimensions. Beyond the clinical aspect, this growing threat demands interdisciplinary solutions that bridge economic theory and practice.
Effects of semaglutide on one-year medical costs among patients with obesity or overweight in US real world setting
Arora P, Michalak W, Zhao Z, Fiasconaro M, Hong Y, Zhao X, Ó Hartaigh B, Alvarez S and Fitch A
Patients with obesity or overweight are at increased risk for obesity-related complications (ORCs), including cardiovascular disease. Treatment with once-weekly (OW) semaglutide 2.4 mg has demonstrated clinical efficacy, however its impact on healthcare resource utilization (HCRU) and costs warrants further investigation.
Institutional single-center cost-opportunity analysis of disposable vs. reusable cystoscopes in a referral oncology center
Franzoso G, Zorzetto G, Dal Bello S, Giuriola A, Casarin A, Stefàno A, Zanandrea M, Zanon S, Rigon L, Porreca A, Amodeo A and Coppola M
Cystoscopy is a high-frequency endoscopic procedure requiring sustainable and evidence-based device management strategies.
Cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (2019-2025): a systematic review
Mugari C, Lukwa AT, Okova D, Chiwire P and Hiligsmann M
This systematic review synthesizes recent evidence on the cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (SSA), where over 70% of the global HIV burden resides.
Workplace productivity losses due to cancer: findings from an Australian longitudinal population survey (2009-2021)
Ali MA, Keramat SA, Hashmi R and Lu CY
Cancer survivors face ongoing health challenges that can reduce work capacity, yet the economic impact of workplace productivity losses remains underexamined. We aim to estimate workplace productivity losses, specifically absenteeism and presenteeism, among Australian cancer survivors and quantified associated wage costs.
Cost effectiveness analysis of continuous glucose monitoring versus self-monitoring of blood glucose in type 2 diabetes patients in Iran
Mohammadi A, Daroudi R, Mousavi A, Olyaeemanesh A, Nasli-Esfahani E, Shafiee G, Heshmat R, Takian A and Darvishi A
One of the novel methods of blood glucose monitoring is continuous glucose monitoring (CGM). This study aims to evaluate the cost-effectiveness of CGM versus self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes (T2D) in Iran.
Enhancing vaccine acceptance: a mixed methods approach to health promotion and willingness to pay among low-income Vietnamese communities
Tran QV, Nguyen TTH, Thanh Nguyen H, Nguyen BT, Pham VNH, Anuratpanich L, Lam Vu T, Ngoc Phuong Ta A, Nguyen HTT, Nguyen CDQ, Van Nguyen P, Vo NX, My Thuc Truong U, Tang HK, Duc Phung N and Vo TQ
This inquiry assesses the willingness to pay (WTP) for a COVID-19 vaccination in Vietnam, and uses a mixed-method approach to investigate how economic, social, and health factors influence acceptance of a vaccine and payment preferences.
Standardized pharmaceutical service improves medication adherence and reduces anxiety and depression in patients with chronic obstructive pulmonary disease
Lin M, Chen Y, Zou Q, Wang Z, Chen Z and Liu Y
To evaluate the effects of standardized pharmaceutical service (SPS) on medication adherence, anxiety, and depression in patients with chronic obstructive pulmonary disease (COPD).
Cost-effectiveness analysis of ribociclib versus palbociclib as a first line theraphy in HR+/HER2- advanced breast cancer: evidence from the Chilean public health system
Balmaceda C, Armijo N and Espinoza M
Ribociclib plus letrozole significantly improves survival in HR+/HER2- advanced-stage or metastatic postmenopausal breast cancer (BC) patients.
Structural and socio-cultural barriers to HIV prevention tools among key populations: a scoping review
Dergham M, Savall A, Chaux R, Hutzler M, Charles R and Gagneux-Brunon A
Despite decades of HIV prevention efforts, key populations - MSM, transgender people, PWUD, sex workers, and migrants - remain disproportionately affected by HIV. Although prevention tools are widely available, global targets remain unmet, largely due to persistent structural and sociocultural barriers, resulting in an important societal cost.
Patients' preferences for atopic dermatitis treatments in Europe: a discrete choice experiment
Heinz KC, Beaudart C, De Greef A, Vanhooteghem O, Gostynski A and Hiligsmann M
Atopic dermatitis (AD) is a chronic skin disease that affects patients' quality of life. Adequate treatment is important but patients' preferences are not fully understood. This study aimed to investigate which treatment attributes are most important for adult European AD patients.
Advancing the economics of prevention: emerging methods and approaches
Grimm SE, van Mastrigt G and Hiligsmann M
There is global consensus on the critical role of prevention in improving population health and reducing long-term healthcare costs. However, investment in prevention remains comparatively limited. With governments increasingly prioritizing prevention, this may be poised to change.
Management of low back pain in the Brazilian public health system: budget impact analysis of the implementation of Pilates exercises compared to usual care
Carregaro RL, Jornada Ben Â, de Toledo AM, Marques YA, Tottoli CR, Ostelo R, Peixoto HM and Bosmans JE
Low back pain (LBP) is a disabling condition affecting all age groups globally. Exercise is safe and cost-effective for managing LBP. Pilates is an effective exercise modality recommended for LBP but is not reimbursed by the Brazilian Public Health System. This study aimed to estimate the budget impact of implementing Pilates for LBP patients within the Brazilian public health system compared to usual care.
The effect of adding a vision dimension to the EQ-5D-5L in patients with visual impairment: a bolt-on exploratory study
Emamgholipour S, Daroudi R and Raadabadi M
One approach to address the limitations of the EQ-5D-5L questionnaire is to add additional dimensions. This study investigated the effect of adding a vision dimension to the EQ-5D-5L questionnaire on health state valuations in people with visual impairments.
The direct and indirect costs of osteoporosis in the Iranian population: an economic analysis from a social perspective
Ravangard R, Izadi M, Dabbaghmanesh MH, Goudarzi Z, Rezaee M and Keshavarz K
Osteoporosis is a systemic skeletal disease and has a high prevalence in Iran. This study aimed to calculate the economic burden of osteoporosis in patients referred to the Shahid Motahari Clini in 2023.
Timely access to new drugs in a single-payer system: policy analysis from South Korea's reimbursement framework
Seung-Lai Y
Timely access to innovative medicines remains a policy challenge in single-payer systems. South Korea has introduced mechanisms such as economic evaluation exemptions and risk-sharing agreements (RSAs) to improve access while maintaining expenditure controls. However, empirical evidence on their real-world impact remains limited.