De novo human leukocyte antigen-DQ (HLA-DQ) donor-specific antibodies (DSAs) significantly impact graft survival after solid organ transplantation. In Korea, where organ allocation policies do not mandate DQ typing, detection of DQ de novo donor-specific antibodies (dnDSAs) remains challenging. This retrospective single-center study investigated the incidence of DQ dnDSAs and its association with DQ mismatches among Korean deceased donor transplantation.

Cardiovascular disease (CVD) is a significant concern after solid organ transplantation, partly due to the adverse effects of immunosuppressive therapy. However, the incidence of major adverse cardiovascular events (MACE) in patients without prior CVD among this population is not well understood. This study aimed to evaluate the occurrence of MACE in lung transplant recipients (LTRs) without pre-existing CVD.

Renal allograft nephrectomy remains a complex and high-risk procedure, often performed following graft failure. While its indications and outcomes vary, the optimal timing for nephrectomy remains controversial.

Hyponatremia in patients with ESLD is a relatively common and serious condition that warrants gradual and meticulous correction to avoid rapid increase in serum sodium concentration, which can lead to osmotic demyelination syndrome, a devastating, potentially lethal, neurologic complication. Intraoperative management of hyponatremia in patients undergoing a liver transplant presents a substantial challenge because many surgery-related factors can result in a rapid increase in sodium concentration, such as massive transfusion of blood products, fluid shifts, and more. We present two cases, where recipients of liver transplants with severe/profound hyponatremia were successfully managed intraoperatively by using continuous veno-venous hemodialysis with specially modified dialysate.

The efficacy of belatacept for maintenance immunosuppression after kidney transplantation is well-established in the literature. Although this medication is being increasingly used as a strategy to avoid calcineurin inhibitors, which are associated with numerous adverse effects, patient satisfaction with monthly belatacept infusions is not well understood.

To assess long-term ocular complications and identify factors affecting these complications who have undergone liver transplantation.

Historically, ABO incompatibility (ABOi) has been considered a relative contraindication to liver transplant (LT) due to inferior postoperative outcomes. We seek to reassess ABOi LTs as an underused graft supply.

Organ donation remains a critical and sensitive issue, yet the factors influencing the decision to donate among citizens of potential donors are not well understood. This study aims to explore demographic characteristics, awareness, decision-making process, and factors influencing organ donation willingness among citizens of organ donation candidates.

Kidney transplantation is the preferred treatment for end-stage renal disease. In Pakistan, living related kidney donors constitute the primary source of kidney transplantation. However, data on postdonation outcomes in this population remain limited.

Hypothermic oxygenated machine perfusion (MP) contributes to the reduction of delayed graft function and ischemic reperfusion injury in donated after circulatory death donors. In this study, we focused on perfusate temperature, oxygen consumption, and oxygen supply and proposed the possibility of assessing organ function. We also calculated the oxygen supply volume for membrane, pressure, dissolved, and bubble dissolved oxygen supply methods during MP, and summarized the optimal oxygen supply methods. The consumption of adult human kidney and liver based on body surface area was converted to 5.3, 1.6, 0.6, and 0.4 mL/min for human kidney, and 86.9, 31.9, 14.3, and 9.6 mL/min for human liver (37, 22, 10, and 4°C, respectively). The results suggest that a compact oxygenation method is sufficient to supply oxygen at temperatures below 10°C, the hypothermic oxygenated MP temperature range, and that new oxygenation techniques should be investigated.

Abdominal organ transplant recipients with obesity can benefit from lifestyle modification interventions for weight loss. We aimed to assess the feasibility, acceptability, and appropriateness of a lifestyle modification intervention using connected health services (Fitbit and scale), coaching phone calls, and virtual group educational sessions.

BK virus (BKV) poses a significant threat to kidney transplantation as it can lead to severe complications, including BK virus nephropathy (BKVN). Many transplant recipients harbor latent BKV, which can reactivate under immunosuppression, leading to viruria, viremia, and potential graft loss. The management of BKVN in human immunodeficiency virus (HIV)-positive patients is especially complex owing to the dual challenge of balancing immunosuppressive therapy and antiretroviral treatment, compounded by potential drug interactions. This study aimed to investigate the incidence, risk factors, and outcomes of BKVN in HIV-positive kidney transplant recipients, comparing these findings to findings in HIV-negative recipients.

Lung transplantation continues to face significant hurdles, mainly regarding graft preservation and minimizing ischemia-reperfusion injury (IRI). Conventional preservation techniques like static cold storage often lead to complications, stimulating the development of ex vivo lung perfusion (EVLP) as a more effective alternative. EVLP offers the advantage of evaluating and treating the graft prior to transplantation, thereby improving the use of extended-criteria donors and donation after circulatory death (DCD). Recent findings demonstrate the potential of normothermic EVLP in reducing IRI damage. Additionally, the application of various temperature settings for EVLP-hypothermic, subnormothermic, and normothermic-shows promise in better preserving lung function. Ventilation strategies also influence graft viability, with negative-pressure ventilation emerging as a potential method to decrease inflammation and damage relative to traditional positive-pressure methods. Furthermore, gas treatments during perfusion, such as hydrogen sulfide, carbon monoxide, and nitric oxide, offer promising avenues to enhance lung graft preservation. Despite the advantages, widespread adoption of EVLP faces challenges, especially related to highlighting the need for cost-effective preservation techniques. Future investigations should focus on deepening our understanding of graft injury mechanisms, especially in DCD models, and refining preservation protocols. Developing more reliable small animal models and aligning studies with the Maastricht classification will help bridge the gap between preclinical research and clinical application, ultimately expanding the donor pool and improving transplantation outcomes.

Presbycusis is an age-related condition characterized by symmetrical bilateral hearing loss that progresses to total deafness in severe cases. Mesenchymal stem cells demonstrate strong therapeutic and regenerative potential, making it worthwhile to explore optimal transplantation pathways for improving age-related hearing loss.

The shortage of donor kidneys has led to the increased use of marginal donors, including those from after circulatory death or extended criteria donors. Hypothermic machine perfusion (HMP) has shown better graft preservation than traditional static cold storage (SCS), particularly when cold ischemia time (CIT) is prolonged. This study evaluated the short-term outcomes of deceased donor kidney transplantation (DDKT) using HMP compared with SCS.

The clinical significance of elevated creatine kinase (CK) levels following living kidney donation (LKD) remains poorly characterized.

Hyperuricemia is a frequent problem after renal transplantation. It is associated with an increased risk of cardiovascular events and graft loss. In the present study, we evaluated whether treatment of hyperuricemia is associated with intrarenal hemodynamic changes as measured by the resistance index (RI).

To identify factors influencing organ donation success among brain-dead patients and evaluate the efficacy of a novel physician-patient communication model ("1T+3S Principles" and "T-F-B Framework").

Unstable donors increase the difficulty and unpredictability of organ donation. The unsuccessful maintenance of unstable donors not only impacts the quality of donor organs, but may also affect the determination of brain or heart death. Two clinical determinations of pediatric brain death in most countries are a requirement. However, an emergency situation, such as cardiac arrest, could be encountered during the brain death determination process.

This study aimed to investigate the impact of multimodal perioperative temperature management on the incidence of perioperative hypothermia in individuals undergoing orthotopic liver transplantation (OLT).

Recurrence contributes a lot to hepatocellular carcinoma (HCC) death. This study aims to evaluate the predictive value of preoperative serum Substance P (SP) levels for post-transplant recurrence in patients with HCC.