Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis
Transition from long-term denosumab to PTH-analogs or romosozumab might expose patients to the risk of the so-called rebound phenomenon. Adding romosozumab to denosumab might represent an option in patients experiencing a fracture while on denosumab. The aim of this study was to investigate the effects of the combination of romosozumab to denosumab in post-menopausal osteoporosis.
Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome
ATP is released from platelets through both degranulation and pannexin-1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium-dependent signaling.
Serious Infections in Offspring Exposed to Tumour Necrosis Factor Inhibitors During Pregnancy: Comparison of Timing During Pregnancy and Placental Transfer Ability
We evaluated serious infection risk in offspring exposed to tumour necrosis factor inhibitors (TNFi) in utero, separated by TNFi timing and placental transfer ability.
Response to "Refining the Interpretation of Drug Survival and Safety in VEXAS Syndrome: The Importance of Competing Risks and Exposure Time" by Pei Y. et al. and "Reinterpreting the Efficacy of IL-1 Inhibitors in VEXAS Syndrome: A Matter of Superiority or Sequencing?" by Ding Z. et al
Distinct natural killer cell signature in still's disease: Insights from a multinational immunome project consortium for autoinflammatory disorders
Still's disease (SD) is a rare systemic inflammatory disorder of unknown origin, characterized by episodes of uncontrolled inflammation. While natural killer (NK) cells have been implicated in SD pathogenesis, their precise role remains elusive.
Refining the Interpretation of Drug Survival and Safety in VEXAS Syndrome: The Importance of Competing Risks and Exposure Time
Autoantigen peptide-8-arm PEG-Dyes (APP-Dyes) specifically recognize antigen-specific B cells and improve the diagnosis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic chronic disabling autoimmune disease with high autoantibody production. However, approximately 1/3 of RA patients are autoantibodies-negative lacking biomarkers. Antigen-specific B cells are critical participants in RA pathogenesis by producing autoantibodies, driving inflammation and joint damage. Nevertheless, the limited detection methods have impeded in-depth studies on these cells. This study aimed to develop a novel probe to precisely recognize these cells and evaluate their diagnostic potential for RA.
Low-Grade Proteinuria Does Not Predict Favorable Outcomes in Lupus Nephritis: A Longitudinal Cohort Study
To investigate the clinical characteristics, renal pathology treatment responses, and renal outcomes of lupus nephritis (LN) patients with different levels of baseline proteinuria.
Reinterpreting the Efficacy of IL-1 Inhibitors in VEXAS Syndrome: A Matter of Superiority or Sequencing?
The limitations on urate's role in knee osteoarthritis studies: comment on the article by Xu et al
Reply to Redlining, Structural Racism, and Psoriatic Arthritis Outcomes
STOP-ing Rheumatoid Arthritis-Lessons Learned From the Latest Prevention Trial
Redlining, Structural Racism, and Psoriatic Arthritis Outcomes: Underrecognized Limitations and Clinical Implications
Interleukin-33 Promotes Interstitial Lung Disease in Idiopathic Inflammatory Myopathy via ERK-Mediated Epithelial-Mesenchymal Transition: ERK as a potential therapeutic target
Interstitial lung disease (ILD) is the most common and prognostically severe complication of idiopathic inflammatory myopathy (IIM), for which targeted treatments remain limited. Based on previous findings that neutrophil extracellular traps (NETs) are key mediators in IIM-ILD pathogenesis and given the established role of IL-33 in promoting NETosis, we hypothesized.
The impact of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: 10-year results from an inception cohort
This study aims to investigate the impact of non-steroidal anti-inflammatory drug (NSAID) intake on radiographic spinal progression in axial spondyloarthritis (axSpA), considering different NSAID types (COX-2 inhibitors [COX2i] and non-selective NSAIDs [ns-NSAIDs]) and disease subgroups (radiographic (r-axSpA) and non-radiographic (nr-axSpA).
Dosing Biologic Drugs for Patients with Obesity: One Size Does NOT Fit All
Exposure to occupational inhalants and the risk of developing rheumatoid arthritis: A systematic review and meta-analysis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint pain, swelling, and stiffness. While smoking is a well-established risk factor for RA, the role of occupational inhalants in RA development is less well recognized. This study aimed to systematically review and synthesize existing evidence on the association between occupational inhalants and the risk of developing RA.
MDSC-derived IFN-β promotes T follicular helper cell response and exacerbates lupus development
Increasing evidence highlights a critical role of T follicular helper (Tfh) cells in autoimmune pathogenesis. This study aimed to identify inflammatory cytokines involved in driving Tfh cell responses in systemic lupus erythematosus (SLE).
Unusual Cervical Pain in Ankylosing Spondylitis: Eagle Syndrome
Special Issue: ACR Convergence 2025 October 24-29, 2025 Chicago, IL
For a searchable version of these abstracts, please visit www.acrabstracts.org.
